SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j7h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		4 / 5 GLU A  87
PRO A 281
ILE A 280
GLY A  88
 None
 1.11A 2qeuA-4j7hA:
undetectable
2qeuC-4j7hA:
undetectable		 2qeuA-4j7hA:
14.93
2qeuC-4j7hA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		4 / 9 ILE A  86
PHE A 303
VAL A 305
GLU A 294
 None
 0.84A 2vufA-4j7hA:
undetectable		 2vufA-4j7hA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		4 / 6 LEU A 145
ASN A  52
LYS A 137
ASP A 216
 None
None
TLO  A 501 ( 4.8A)
None
 1.38A 2w98A-4j7hA:
undetectable
2w98B-4j7hA:
undetectable		 2w98A-4j7hA:
22.33
2w98B-4j7hA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 7 ARG A 181
VAL A 242
LEU A 133
LEU A 228
MET A 229
 None
 1.46A 3gp0A-4j7hA:
undetectable		 3gp0A-4j7hA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		4 / 7 VAL A 211
TYR A 173
TRP A 219
GLU A 206
 None
 1.23A 3hs4A-4j7hA:
undetectable		 3hs4A-4j7hA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		3 / 3 GLU A 139
GLU A 190
ASN A 238
 None
 0.81A 3lp9B-4j7hA:
undetectable
3lp9D-4j7hA:
undetectable		 3lp9B-4j7hA:
17.73
3lp9D-4j7hA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_A_LLTA261_1
(DEOXYCYTIDINE KINASE)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 10 VAL A 348
LEU A 362
GLN A 438
PHE A 257
GLU A 269
 None
 1.02A 3qeoA-4j7hA:
0.0		 3qeoA-4j7hA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 385
VAL A 332
PRO A 370
HIS A 375
GLY A 300
 None
 1.31A 4hvcB-4j7hA:
undetectable		 4hvcB-4j7hA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		4 / 8 MET A 229
ALA A 226
THR A 443
VAL A 449
 None
 0.97A 4ltwA-4j7hA:
undetectable		 4ltwA-4j7hA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 385
VAL A 332
PRO A 370
HIS A 375
GLY A 300
 None
 1.33A 4q15A-4j7hA:
undetectable		 4q15A-4j7hA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 GLU A 139
GLY A 407
GLN A 135
LEU A 119
PRO A 150
 None
 1.14A 4uilH-4j7hA:
undetectable
4uilL-4j7hA:
undetectable		 4uilH-4j7hA:
17.32
4uilL-4j7hA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 385
VAL A 332
PRO A 370
HIS A 375
GLY A 300
 None
 1.29A 4ydqA-4j7hA:
undetectable		 4ydqA-4j7hA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		4 / 8 GLU A 399
LEU A 417
ARG A 393
LEU A 385
 None
None
EDO  A 504 (-4.3A)
None
 1.15A 5dxeA-4j7hA:
undetectable		 5dxeA-4j7hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		3 / 3 GLY A 406
GLY A 407
GLN A 153
 None
None
TLO  A 501 (-4.0A)
 0.44A 5imsA-4j7hA:
undetectable		 5imsA-4j7hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		4 / 6 ARG A 279
PRO A 114
THR A  85
GLU A  87
 None
 1.03A 5ny7A-4j7hA:
undetectable		 5ny7A-4j7hA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		3 / 3 HIS A 297
GLU A 298
TRP A 288
 TRH  A 502 ( 4.7A)
None
TRH  A 502 (-3.9A)
 1.18A 5odiD-4j7hA:
undetectable		 5odiD-4j7hA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		3 / 3 HIS A 297
GLU A 298
TRP A 288
 TRH  A 502 ( 4.7A)
None
TRH  A 502 (-3.9A)
 1.19A 5odrD-4j7hA:
undetectable		 5odrD-4j7hA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		4 / 6 ARG A 278
ARG A 279
ILE A  86
THR A  85
 None
 1.13A 5vceA-4j7hA:
undetectable		 5vceA-4j7hA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 GLU A 361
VAL A  91
LEU A  89
GLY A 192
ARG A 454
 None
 1.18A 5vooC-4j7hA:
undetectable		 5vooC-4j7hA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 GLU A 361
VAL A  91
LEU A  89
GLY A 192
ARG A 454
 None
 1.17A 5vooE-4j7hA:
undetectable		 5vooE-4j7hA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 385
VAL A 332
PRO A 370
HIS A 375
GLY A 300
 None
 1.27A 5xiqA-4j7hA:
undetectable		 5xiqA-4j7hA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 385
VAL A 332
PRO A 370
HIS A 375
GLY A 300
 None
 1.31A 5xiqD-4j7hA:
undetectable		 5xiqD-4j7hA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		4 / 5 GLY A 342
ASP A 341
ARG A 338
GLN A 438
 None
 1.48A 5zrfB-4j7hA:
undetectable		 5zrfB-4j7hA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 ILE A 419
VAL A 366
ALA A 334
LEU A 371
ARG A 415
 EDO  A 505 (-4.7A)
None
None
None
EDO  A 504 (-4.2A)
 1.48A 6a7pB-4j7hA:
undetectable		 6a7pB-4j7hA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		4 / 8 GLU A 399
LEU A 417
ARG A 393
LEU A 385
 None
None
EDO  A 504 (-4.3A)
None
 1.20A 6cbzA-4j7hA:
undetectable		 6cbzA-4j7hA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		3 / 3 ARG A 181
HIS A  18
ARG A  23
 None
 1.06A 6dwdD-4j7hA:
undetectable		 6dwdD-4j7hA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 GLY A 354
GLY A 355
GLY A 430
ASN A 450
GLN A 367
 None
None
None
None
TRH  A 502 (-4.1A)
 0.97A 6gngB-4j7hA:
undetectable		 6gngB-4j7hA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4j7h EVAA 2,3-DEHYDRATASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 385
VAL A 332
PRO A 370
HIS A 375
GLY A 300
 None
 1.33A 6mn8A-4j7hA:
undetectable		 6mn8A-4j7hA:
20.15