SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		5 / 11 LEU A  67
GLU A  48
TYR A 251
SER A 218
GLU A 234
 None
None
None
None
U  B   1 ( 3.6A)
 1.48A 1fdtA-4j7mA:
undetectable		 1fdtA-4j7mA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		5 / 12 LEU A 103
LEU A 107
VAL A 110
LEU A 230
ALA A 127
 None
 0.97A 1gseB-4j7mA:
undetectable		 1gseB-4j7mA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		3 / 3 LEU A  54
TRP A 109
TYR A 216
 None
 1.01A 3aicA-4j7mA:
undetectable		 3aicA-4j7mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		3 / 3 LEU A  54
TRP A 109
TYR A 216
 None
 0.98A 3aicB-4j7mA:
undetectable		 3aicB-4j7mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		3 / 3 LEU A  54
TRP A 109
TYR A 216
 None
 1.00A 3aicE-4j7mA:
undetectable		 3aicE-4j7mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		3 / 3 LEU A  54
TRP A 109
TYR A 216
 None
 0.99A 3aicH-4j7mA:
undetectable		 3aicH-4j7mA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 7 PHE A 306
PHE A 269
TYR A 270
GLY A 321
 None
 0.89A 3em0B-4j7mA:
undetectable		 3em0B-4j7mA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 8 PHE A  40
LEU A 224
TYR A  43
PHE A 282
 None
 0.90A 3i45A-4j7mA:
undetectable		 3i45A-4j7mA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 6 LEU A 135
ALA A 153
LEU A 160
THR A 128
 None
 1.07A 3rozA-4j7mA:
undetectable		 3rozA-4j7mA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 6 LEU A 106
ALA A 127
THR A 159
LEU A 117
 None
 0.98A 3t3zA-4j7mA:
undetectable		 3t3zA-4j7mA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 6 LEU A 106
ALA A 127
THR A 159
LEU A 117
 None
 1.00A 3t3zB-4j7mA:
undetectable		 3t3zB-4j7mA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		5 / 12 LEU A 160
PHE A 353
VAL A 342
PHE A 373
ALA A 152
 None
 1.27A 3u9fG-4j7mA:
undetectable
3u9fH-4j7mA:
undetectable		 3u9fG-4j7mA:
17.59
3u9fH-4j7mA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 7 ARG A 221
LEU A 230
GLY A  50
SER A 218
 None
 0.99A 4cp3A-4j7mA:
undetectable
4cp3B-4j7mA:
undetectable		 4cp3A-4j7mA:
14.99
4cp3B-4j7mA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 7 SER A 154
ALA A 152
SER A 163
ARG A 102
 None
 1.23A 4lv9A-4j7mA:
undetectable
4lv9B-4j7mA:
undetectable		 4lv9A-4j7mA:
20.08
4lv9B-4j7mA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		3 / 3 TRP A 149
GLN A 280
THR A 140
 None
U  B   1 ( 4.3A)
None
 0.88A 4m2xA-4j7mA:
undetectable		 4m2xA-4j7mA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 6 VAL A 361
LEU A  29
LEU A 138
PHE A 373
 None
 0.77A 4o1zA-4j7mA:
undetectable		 4o1zA-4j7mA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		5 / 9 LEU A 124
LEU A  49
SER A 232
LEU A 220
VAL A 219
 None
 1.12A 4or0B-4j7mA:
undetectable		 4or0B-4j7mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 7 ALA A 127
THR A 159
TYR A 161
VAL A 110
 None
 1.20A 5ecnA-4j7mA:
undetectable		 5ecnA-4j7mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 6 LEU A 151
CYH A 331
HIS A 134
LEU A 135
 None
 1.46A 5hrqD-4j7mA:
undetectable
5hrqG-4j7mA:
undetectable
5hrqH-4j7mA:
undetectable		 5hrqD-4j7mA:
5.34
5hrqG-4j7mA:
4.68
5hrqH-4j7mA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 5 LEU A 139
PHE A  40
LEU A 224
TRP A 278
 None
 1.34A 5m10A-4j7mA:
undetectable		 5m10A-4j7mA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 6 GLN A 339
ARG A 155
THR A 141
PHE A 330
 None
 1.41A 5mwyA-4j7mA:
undetectable		 5mwyA-4j7mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 7 GLN A  32
LEU A  35
ALA A 332
LEU A 335
 UBD  A 401 (-3.0A)
None
None
None
 0.97A 5nwvA-4j7mA:
undetectable		 5nwvA-4j7mA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		5 / 10 LEU A 124
GLY A 122
GLY A 120
ARG A 223
ALA A 127
 None
 0.85A 5o96E-4j7mA:
undetectable
5o96F-4j7mA:
undetectable		 5o96E-4j7mA:
18.72
5o96F-4j7mA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		5 / 11 LEU A 124
GLY A 122
GLY A 120
ARG A 223
ALA A 127
 None
 0.85A 5o96G-4j7mA:
undetectable		 5o96G-4j7mA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		3 / 3 HIS A 113
GLU A 112
TRP A 109
 None
UBD  A 402 (-4.7A)
None
 1.04A 5odqD-4j7mA:
undetectable		 5odqD-4j7mA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		3 / 3 HIS A 113
GLU A 112
TRP A 109
 None
UBD  A 402 (-4.7A)
None
 0.96A 5odrD-4j7mA:
undetectable		 5odrD-4j7mA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 4 ARG A 171
GLU A 166
GLU A  98
ARG A 174
 None
 1.11A 6fk2A-4j7mA:
undetectable		 6fk2A-4j7mA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4j7m PROTEIN DOM3Z
(Mus
musculus) 		4 / 7 VAL A 129
LEU A 124
LEU A 117
LEU A 107
 None
 0.74A 6g9bA-4j7mA:
undetectable
6g9bB-4j7mA:
undetectable		 6g9bA-4j7mA:
13.50
6g9bB-4j7mA:
14.29