SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j7q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.91A 1jffB-4j7qA:
undetectable		 1jffB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 237
LEU A 195
ILE A 199
PRO A 162
GLN A 145
 B7N  A 401 (-3.9A)
B7N  A 401 ( 4.9A)
None
None
None
 1.27A 2ft9A-4j7qA:
undetectable		 2ft9A-4j7qA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.91A 2hxfB-4j7qA:
undetectable		 2hxfB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.91A 2hxhB-4j7qA:
undetectable		 2hxhB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.91A 2p4nB-4j7qA:
undetectable		 2p4nB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.91A 2wbeB-4j7qA:
undetectable		 2wbeB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 128
HIS A 127
ILE A 131
GLU A 125
 None
 0.93A 2x0pA-4j7qA:
undetectable		 2x0pA-4j7qA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		4 / 7 GLU A  37
TYR A 342
ARG A  87
GLU A  88
 None
 1.26A 2zt7A-4j7qA:
undetectable		 2zt7A-4j7qA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.91A 3dcoB-4j7qA:
undetectable		 3dcoB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.90A 3edlB-4j7qA:
undetectable		 3edlB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.89A 3iz0B-4j7qA:
undetectable		 3iz0B-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 309
ASP A 186
ASP A 313
 None
 0.78A 3jayA-4j7qA:
undetectable		 3jayA-4j7qA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 309
ASP A 186
ASP A 313
 None
 0.81A 3jb2A-4j7qA:
undetectable		 3jb2A-4j7qA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 151
VAL A 278
LEU A 241
VAL A 269
 None
 1.05A 4lb0B-4j7qA:
undetectable		 4lb0B-4j7qA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 7 LEU A 101
VAL A 100
LYS A  46
TYR A  48
GLU A  50
 None
 1.28A 4lb2A-4j7qA:
undetectable		 4lb2A-4j7qA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 117
THR A 231
HIS A 232
 None
 0.80A 4q15A-4j7qA:
undetectable		 4q15A-4j7qA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 117
THR A 231
HIS A 232
 None
 0.82A 4q15B-4j7qA:
undetectable		 4q15B-4j7qA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 117
THR A 231
HIS A 232
 None
 0.74A 4ydqB-4j7qA:
undetectable		 4ydqB-4j7qA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		4 / 7 GLU A  78
GLY A 128
SER A 121
GLY A 119
 None
 0.68A 5e26A-4j7qA:
undetectable
5e26B-4j7qA:
undetectable		 5e26A-4j7qA:
22.14
5e26B-4j7qA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		4 / 7 GLU A  78
GLY A 128
SER A 121
GLY A 119
 None
 0.68A 5e26C-4j7qA:
undetectable
5e26D-4j7qA:
undetectable		 5e26C-4j7qA:
22.14
5e26D-4j7qA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.89A 5hnwB-4j7qA:
undetectable		 5hnwB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 177
ARG A 164
 None
None
None
B7N  A 401 (-4.3A)
None
 1.19A 5hnwB-4j7qA:
undetectable		 5hnwB-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 158
ARG A 164
 None
 0.89A 5hnyB-4j7qA:
undetectable		 5hnyB-4j7qA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 177
ARG A 164
 None
None
None
B7N  A 401 (-4.3A)
None
 1.15A 5hnyB-4j7qA:
undetectable		 5hnyB-4j7qA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		4 / 5 GLU A  78
GLY A 128
SER A 121
GLY A 119
 None
 0.72A 5kprA-4j7qA:
undetectable		 5kprA-4j7qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		4 / 8 THR A 109
CYH A  89
TYR A  93
LEU A  85
 None
 1.43A 5kxiA-4j7qA:
undetectable
5kxiB-4j7qA:
undetectable		 5kxiA-4j7qA:
22.89
5kxiB-4j7qA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		4 / 8 THR A 109
CYH A  89
TYR A  93
LEU A  85
 None
 1.46A 5kxiD-4j7qA:
undetectable
5kxiE-4j7qA:
undetectable		 5kxiD-4j7qA:
22.89
5kxiE-4j7qA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 136
LEU A 160
HIS A 176
LEU A 177
ARG A 164
 None
None
None
B7N  A 401 (-4.3A)
None
 1.21A 5nd7B-4j7qA:
undetectable		 5nd7B-4j7qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 287
TYR A 159
ILE A 157
TYR A 150
ILE A  25
 None
 1.49A 5u98A-4j7qA:
undetectable		 5u98A-4j7qA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 115
ARG A 183
ARG A 236
 None
 1.07A 6bplA-4j7qA:
undetectable
6bplB-4j7qA:
undetectable		 6bplA-4j7qA:
13.89
6bplB-4j7qA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4j7q PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
PDR16
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 184
LEU A 158
LEU A 197
LEU A 177
 None
None
B7N  A 401 (-4.6A)
B7N  A 401 (-4.3A)
 1.07A 6f6sA-4j7qA:
undetectable
6f6sB-4j7qA:
undetectable		 6f6sA-4j7qA:
13.74
6f6sB-4j7qA:
13.33