SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_2
(ANDROGEN RECEPTOR)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A 255
MET A   1
MET A   3
VAL A 236
 None
 1.41A 1gs4A-4j8bA:
0.0		 1gs4A-4j8bA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 224
PRO A 225
LEU A 226
ARG A 288
 None
 1.14A 1hrkB-4j8bA:
undetectable		 1hrkB-4j8bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 HIS A 255
LEU A 326
THR A 305
ILE A 304
PHE A 324
 None
 1.21A 1xlxA-4j8bA:
undetectable		 1xlxA-4j8bA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 224
PRO A 225
LEU A 226
ARG A 288
 None
 1.18A 2hrcB-4j8bA:
undetectable		 2hrcB-4j8bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 11 ASN A  78
VAL A  69
PHE A  68
ALA A  18
ASP A  53
 None
 1.27A 2iyfA-4j8bA:
undetectable		 2iyfA-4j8bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 224
PRO A 225
LEU A 226
ARG A 288
 None
 1.20A 2pnjB-4j8bA:
undetectable		 2pnjB-4j8bA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 224
PRO A 225
LEU A 226
ARG A 288
 None
 1.07A 2qd2A-4j8bA:
undetectable		 2qd2A-4j8bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A  41
GLN A  23
PRO A  24
 None
 0.50A 2qhfA-4j8bA:
undetectable		 2qhfA-4j8bA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 THR A 305
PHE A 303
ALA A 144
VAL A 100
GLY A  58
 None
 1.29A 2ve3B-4j8bA:
undetectable		 2ve3B-4j8bA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 5 SER A  90
HIS A  94
VAL A  98
ASP A  74
 None
 1.48A 4eohB-4j8bA:
undetectable		 4eohB-4j8bA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 8 MET A 322
PHE A 324
ALA A   2
LEU A 326
 None
 1.04A 4rkuA-4j8bA:
undetectable
4rkuJ-4j8bA:
undetectable		 4rkuA-4j8bA:
19.27
4rkuJ-4j8bA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A  59
GLY A  16
ALA A 315
ARG A  57
HIS A  31
 None
 1.01A 4rvdA-4j8bA:
undetectable		 4rvdA-4j8bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A  34
THR A  28
TRP A  38
 None
 1.09A 4ug5A-4j8bA:
undetectable		 4ug5A-4j8bA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 6 GLY A  72
ASP A  73
ARG A  57
GLY A  58
 None
 0.69A 5cdnA-4j8bA:
undetectable
5cdnB-4j8bA:
undetectable		 5cdnA-4j8bA:
18.88
5cdnB-4j8bA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 6 GLY A  72
ASP A  73
ARG A  57
GLY A  58
 None
 0.67A 5cdnC-4j8bA:
undetectable
5cdnD-4j8bA:
undetectable		 5cdnC-4j8bA:
18.88
5cdnD-4j8bA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 6 GLY A  72
ASP A  73
ARG A  57
GLY A  58
 None
 0.69A 5cdnT-4j8bA:
undetectable
5cdnU-4j8bA:
undetectable		 5cdnT-4j8bA:
18.88
5cdnU-4j8bA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 6 GLY A  72
ASP A  73
ARG A  57
GLY A  58
 None
 0.77A 5cdpA-4j8bA:
undetectable
5cdpB-4j8bA:
undetectable		 5cdpA-4j8bA:
18.69
5cdpB-4j8bA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A 207
SER A 137
MET A 141
 None
 0.87A 5ikqA-4j8bA:
undetectable		 5ikqA-4j8bA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4j8b COATOMER ALPHA
SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 214
ASP A 233
ASN A 216
CYH A 218
CYH A 142
 None
 1.49A 6ineA-4j8bA:
undetectable		 6ineA-4j8bA:
20.43