SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 GLY A 224
ASP A 206
ASP A 199
GLY A 202
GLY A 229
 None
PO4  A 603 ( 4.7A)
MG  A 602 ( 3.9A)
ADP  A 601 (-3.4A)
None
 0.89A 1hxbA-4j8fA:
undetectable		 1hxbA-4j8fA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 GLY A  19
ALA A 370
SER A  16
ALA A 131
ILE A   7
 None
 1.12A 1nt2A-4j8fA:
undetectable		 1nt2A-4j8fA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 GLY A 230
GLY A 202
GLY A 203
LEU A 228
ASN A 235
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.4A)
None
None
None
 0.87A 1qzzA-4j8fA:
undetectable		 1qzzA-4j8fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 TYR A  41
GLY A 230
GLY A 202
LEU A 228
ASN A 235
 None
ADP  A 601 (-3.4A)
ADP  A 601 (-3.4A)
None
None
 1.00A 1qzzA-4j8fA:
undetectable		 1qzzA-4j8fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		3 / 3 ASP A  32
GLU A  48
ARG A 479
 None
 0.72A 1wopA-4j8fA:
undetectable		 1wopA-4j8fA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		4 / 7 TYR A 137
ASN A 471
HIS A 503
VAL A 139
 None
 1.11A 1wu8A-4j8fA:
undetectable
1wu8C-4j8fA:
undetectable		 1wu8A-4j8fA:
18.97
1wu8C-4j8fA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 GLY A 230
GLY A 202
GLY A 203
LEU A 228
ASN A 235
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.4A)
None
None
None
 0.90A 1xdsA-4j8fA:
undetectable		 1xdsA-4j8fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 GLY A 230
GLY A 202
GLY A 203
LEU A 228
ASN A 235
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.4A)
None
None
None
 0.88A 1xdsB-4j8fA:
undetectable		 1xdsB-4j8fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		4 / 7 ILE A   7
THR A 158
ILE A  29
GLY A  12
 None
None
None
PO4  A 603 (-3.3A)
 0.93A 2v0mB-4j8fA:
undetectable		 2v0mB-4j8fA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 10 ALA A 157
GLY A 162
ILE A 164
ALA A  70
ILE A  74
 None
 0.94A 3ekpB-4j8fA:
undetectable		 3ekpB-4j8fA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 10 ALA A 157
GLY A 162
ILE A 164
ALA A  70
ILE A  74
 None
 1.00A 3ekpC-4j8fA:
undetectable		 3ekpC-4j8fA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 9 ALA A 157
GLY A 162
ILE A 164
ALA A  70
ILE A  74
 None
 1.00A 3ektB-4j8fA:
undetectable		 3ektB-4j8fA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		6 / 10 ALA A 157
ILE A 144
GLY A 162
ILE A 164
ALA A  70
ILE A  74
 None
 1.16A 3ekwA-4j8fA:
undetectable		 3ekwA-4j8fA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		4 / 4 PHE A 245
LYS A 246
ILE A 291
THR A 295
 None
 0.76A 3ia4B-4j8fA:
undetectable		 3ia4B-4j8fA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		3 / 3 ARG A  72
ASP A  80
ASP A  86
 None
 0.88A 3jayA-4j8fA:
undetectable		 3jayA-4j8fA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 10 ILE A 212
ALA A 178
ILE A 197
VAL A 335
VAL A 195
 None
 0.93A 3me6A-4j8fA:
undetectable		 3me6A-4j8fA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 GLY A 495
ALA A 497
ASP A 522
ALA A 523
ASP A 510
 None
 1.25A 3nvkF-4j8fA:
3.0
3nvkJ-4j8fA:
undetectable		 3nvkF-4j8fA:
23.28
3nvkJ-4j8fA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		4 / 5 ILE A 389
ALA A 534
HIS A 540
ARG A 541
 IOD  A 606 ( 4.7A)
None
None
None
 1.19A 4ac9B-4j8fA:
2.4
4ac9C-4j8fA:
2.2		 4ac9B-4j8fA:
23.62
4ac9C-4j8fA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		4 / 5 ILE A 389
ALA A 534
HIS A 540
ARG A 541
 IOD  A 606 ( 4.7A)
None
None
None
 1.25A 4acaB-4j8fA:
undetectable
4acaC-4j8fA:
2.2		 4acaB-4j8fA:
23.62
4acaC-4j8fA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		4 / 7 GLU A 175
THR A  13
GLY A  12
THR A  14
 PO4  A 603 (-2.9A)
PO4  A 603 ( 3.4A)
PO4  A 603 (-3.3A)
ADP  A 601 (-3.3A)
 0.88A 4qwpB-4j8fA:
undetectable		 4qwpB-4j8fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		3 / 3 TYR A  41
ARG A 261
LYS A  56
 None
IOD  A 617 (-3.5A)
IOD  A 617 (-3.5A)
 1.18A 4wq5B-4j8fA:
10.7		 4wq5B-4j8fA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 ILE A 331
ARG A 193
ALA A 180
LEU A 210
PHE A 354
 None
 1.33A 4zo1X-4j8fA:
undetectable		 4zo1X-4j8fA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		6 / 10 GLY A 201
LYS A 271
ARG A 272
SER A 275
SER A 340
ILE A 343
 ADP  A 601 (-2.9A)
ADP  A 601 (-2.5A)
ADP  A 601 ( 3.7A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.4A)
None
 1.09A 5aqfA-4j8fA:
56.3		 5aqfA-4j8fA:
72.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		6 / 10 GLY A 201
LYS A 271
SER A 275
SER A 340
ARG A 342
ILE A 343
 ADP  A 601 (-2.9A)
ADP  A 601 (-2.5A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.4A)
ADP  A 601 (-4.5A)
None
 1.08A 5aqfA-4j8fA:
56.3		 5aqfA-4j8fA:
72.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		9 / 10 GLY A 202
GLY A 230
GLU A 268
LYS A 271
ARG A 272
SER A 275
GLY A 339
SER A 340
ILE A 343
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.4A)
ADP  A 601 ( 3.0A)
ADP  A 601 (-2.5A)
ADP  A 601 ( 3.7A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.2A)
ADP  A 601 (-3.4A)
None
 0.47A 5aqfA-4j8fA:
56.3		 5aqfA-4j8fA:
72.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		8 / 10 GLY A 202
GLY A 230
LYS A 271
SER A 275
GLY A 339
SER A 340
ARG A 342
ILE A 343
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.4A)
ADP  A 601 (-2.5A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.2A)
ADP  A 601 (-3.4A)
ADP  A 601 (-4.5A)
None
 0.62A 5aqfA-4j8fA:
56.3		 5aqfA-4j8fA:
72.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		6 / 10 GLY A 229
GLY A 230
LYS A 271
SER A 275
SER A 340
ILE A 343
 None
ADP  A 601 (-3.4A)
ADP  A 601 (-2.5A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.4A)
None
 1.36A 5aqfA-4j8fA:
56.3		 5aqfA-4j8fA:
72.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		6 / 10 GLY A 201
LYS A 271
ARG A 272
SER A 275
SER A 340
ILE A 343
 ADP  A 601 (-2.9A)
ADP  A 601 (-2.5A)
ADP  A 601 ( 3.7A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.4A)
None
 1.10A 5aqfC-4j8fA:
55.9		 5aqfC-4j8fA:
72.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		6 / 10 GLY A 201
LYS A 271
SER A 275
SER A 340
ARG A 342
ILE A 343
 ADP  A 601 (-2.9A)
ADP  A 601 (-2.5A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.4A)
ADP  A 601 (-4.5A)
None
 1.09A 5aqfC-4j8fA:
55.9		 5aqfC-4j8fA:
72.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		9 / 10 GLY A 202
GLY A 230
GLU A 268
LYS A 271
ARG A 272
SER A 275
GLY A 339
SER A 340
ILE A 343
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.4A)
ADP  A 601 ( 3.0A)
ADP  A 601 (-2.5A)
ADP  A 601 ( 3.7A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.2A)
ADP  A 601 (-3.4A)
None
 0.48A 5aqfC-4j8fA:
55.9		 5aqfC-4j8fA:
72.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		8 / 10 GLY A 202
GLY A 230
LYS A 271
SER A 275
GLY A 339
SER A 340
ARG A 342
ILE A 343
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.4A)
ADP  A 601 (-2.5A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.2A)
ADP  A 601 (-3.4A)
ADP  A 601 (-4.5A)
None
 0.61A 5aqfC-4j8fA:
55.9		 5aqfC-4j8fA:
72.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		6 / 10 GLY A 229
GLY A 230
LYS A 271
SER A 275
SER A 340
ILE A 343
 None
ADP  A 601 (-3.4A)
ADP  A 601 (-2.5A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.4A)
None
 1.36A 5aqfC-4j8fA:
55.9		 5aqfC-4j8fA:
72.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		8 / 10 GLY A 201
LYS A 271
ARG A 272
SER A 275
GLY A 339
SER A 340
ARG A 342
ILE A 343
 ADP  A 601 (-2.9A)
ADP  A 601 (-2.5A)
ADP  A 601 ( 3.7A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.2A)
ADP  A 601 (-3.4A)
ADP  A 601 (-4.5A)
None
 1.08A 5aqyA-4j8fA:
28.7		 5aqyA-4j8fA:
73.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		6 / 10 GLY A 202
GLU A 268
ARG A 272
GLY A 339
SER A 340
ARG A 342
 ADP  A 601 (-3.4A)
ADP  A 601 ( 3.0A)
ADP  A 601 ( 3.7A)
ADP  A 601 (-3.2A)
ADP  A 601 (-3.4A)
ADP  A 601 (-4.5A)
 1.30A 5aqyA-4j8fA:
28.7		 5aqyA-4j8fA:
73.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		10 / 10 GLY A 202
GLY A 230
GLU A 268
LYS A 271
ARG A 272
SER A 275
GLY A 339
SER A 340
ARG A 342
ILE A 343
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.4A)
ADP  A 601 ( 3.0A)
ADP  A 601 (-2.5A)
ADP  A 601 ( 3.7A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.2A)
ADP  A 601 (-3.4A)
ADP  A 601 (-4.5A)
None
 0.67A 5aqyA-4j8fA:
28.7		 5aqyA-4j8fA:
73.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		6 / 10 GLY A 229
GLY A 230
LYS A 271
SER A 275
SER A 340
ILE A 343
 None
ADP  A 601 (-3.4A)
ADP  A 601 (-2.5A)
ADP  A 601 (-2.7A)
ADP  A 601 (-3.4A)
None
 1.38A 5aqyA-4j8fA:
28.7		 5aqyA-4j8fA:
73.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 ILE A 297
ASP A 234
GLU A 268
SER A 340
ILE A 343
 IOD  A 615 (-4.7A)
ADP  A 601 ( 4.9A)
ADP  A 601 ( 3.0A)
ADP  A 601 (-3.4A)
None
 1.38A 5igwA-4j8fA:
undetectable		 5igwA-4j8fA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		5 / 12 PHE A 233
GLY A 201
GLY A 339
ILE A 343
LEU A 237
 None
ADP  A 601 (-2.9A)
ADP  A 601 (-3.2A)
None
None
 1.01A 5ul4A-4j8fA:
2.4		 5ul4A-4j8fA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		4 / 5 ARG A 475
ALA A 473
GLN A 403
ILE A 440
 None
 1.39A 6f6sA-4j8fA:
undetectable
6f6sB-4j8fA:
undetectable		 6f6sA-4j8fA:
12.21
6f6sB-4j8fA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus) 		3 / 3 ARG A 357
LEU A 334
PHE A 198
 IOD  A 608 ( 4.9A)
None
None
 0.69A 6nknP-4j8fA:
undetectable		 6nknP-4j8fA:
16.07