SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 8 LEU A 197
SER A 193
GLY A  73
TYR A 173
 LLP  A 196 ( 3.7A)
LLP  A 196 ( 3.2A)
None
LLP  A 196 (-3.7A)
 0.83A 1fapB-4j8lA:
undetectable		 1fapB-4j8lA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 8 LEU A 197
SER A 193
GLY A  77
TYR A 173
 LLP  A 196 ( 3.7A)
LLP  A 196 ( 3.2A)
None
LLP  A 196 (-3.7A)
 0.97A 1fapB-4j8lA:
undetectable		 1fapB-4j8lA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 8 ASN A 172
LEU A 197
ALA A 242
LEU A 239
 LLP  A 196 ( 3.9A)
LLP  A 196 ( 3.7A)
None
None
 0.98A 1hwiB-4j8lA:
2.1		 1hwiB-4j8lA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 8 ASN A 172
LEU A 197
ALA A 242
LEU A 239
 LLP  A 196 ( 3.9A)
LLP  A 196 ( 3.7A)
None
None
 0.97A 1hwiC-4j8lA:
undetectable		 1hwiC-4j8lA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		5 / 12 LEU A  83
VAL A 156
LEU A 157
LEU A 160
LEU A  93
 None
 1.23A 1mx1C-4j8lA:
undetectable		 1mx1C-4j8lA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 4 GLN A 287
GLU A 267
ILE A 289
PRO A 288
 None
None
None
NI  A 401 (-4.1A)
 1.41A 2fcnA-4j8lA:
undetectable		 2fcnA-4j8lA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		5 / 12 LEU A  59
ALA A  65
ASP A 209
GLY A 182
ALA A 205
 None
 0.88A 2nmyB-4j8lA:
undetectable		 2nmyB-4j8lA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		5 / 9 GLY A  73
ILE A  79
VAL A 206
ILE A 216
VAL A 212
 None
 1.18A 2nnhB-4j8lA:
undetectable		 2nnhB-4j8lA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		5 / 12 LEU A  59
ALA A  65
ASP A 209
GLY A 182
ALA A 205
 None
 0.90A 2rkfA-4j8lA:
undetectable		 2rkfA-4j8lA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		5 / 10 LEU A  59
ALA A  65
ASP A 209
GLY A 182
ALA A 205
 None
 0.91A 3ekpB-4j8lA:
undetectable		 3ekpB-4j8lA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		5 / 10 LEU A  59
ALA A  65
ASP A 209
GLY A 182
ALA A 205
 None
 0.87A 3ekpC-4j8lA:
undetectable		 3ekpC-4j8lA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 7 GLY A  75
THR A  76
ILE A  79
THR A 143
 LLP  A 196 ( 3.3A)
LLP  A 196 ( 3.6A)
None
LLP  A 196 ( 4.7A)
 0.72A 4acaC-4j8lA:
3.8		 4acaC-4j8lA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		5 / 12 LEU A  70
ALA A 232
LEU A 239
LEU A  21
HIS A  28
 None
 1.18A 4j24D-4j8lA:
undetectable		 4j24D-4j8lA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		5 / 10 GLN A  66
ALA A  65
ALA A  67
ALA A  68
VAL A  71
 None
 1.15A 4j6cB-4j8lA:
undetectable		 4j6cB-4j8lA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		5 / 11 LEU A  83
VAL A  95
LEU A 115
LEU A 168
LEU A 113
 None
 1.30A 4or0B-4j8lA:
undetectable		 4or0B-4j8lA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		3 / 3 ILE A 116
MET A 111
ASP A 136
 None
 0.81A 5h2uA-4j8lA:
undetectable		 5h2uA-4j8lA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		5 / 12 LEU A  83
THR A 104
GLY A  82
VAL A 206
LEU A 139
 None
 1.32A 5jo9A-4j8lA:
undetectable		 5jo9A-4j8lA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 8 ILE A 116
ARG A  92
GLN A  91
VAL A 165
 None
 1.15A 5vlmF-4j8lA:
undetectable		 5vlmF-4j8lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 7 ILE A 116
GLN A 133
VAL A 130
ALA A 163
 None
 0.91A 6cduC-4j8lA:
undetectable
6cduD-4j8lA:
undetectable		 6cduC-4j8lA:
24.10
6cduD-4j8lA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 5 TYR A 101
GLN A 277
GLY A 204
ILE A  79
 LLP  A 196 ( 3.4A)
LLP  A 196 ( 4.6A)
None
None
 1.47A 6debB-4j8lA:
2.4		 6debB-4j8lA:
11.30