SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4j8p FLAVODOXIN
(Bacteroides
uniformis) 		5 / 11 ILE A 156
PHE A 126
ILE A  56
ILE A 121
THR A 130
 None
 1.45A 4p68A-4j8pA:
undetectable		 4p68A-4j8pA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4j8p FLAVODOXIN
(Bacteroides
uniformis) 		3 / 3 ALA A  30
TYR A  31
PRO A  58
 None
 0.63A 4zdyA-4j8pA:
undetectable		 4zdyA-4j8pA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 4j8p FLAVODOXIN
(Bacteroides
uniformis) 		5 / 12 GLY A  36
PHE A 126
TYR A  99
PHE A 120
PHE A  53
 GOL  A 206 ( 3.3A)
None
GOL  A 203 (-4.7A)
None
None
 1.22A 5fsaB-4j8pA:
undetectable		 5fsaB-4j8pA:
16.18