SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4j8r HEAVY CHAIN OF POM2
FAB
LIGHT CHAIN OF POM2
FAB
(Mus
musculus) 		6 / 12 TYR A  35
GLN A  88
PHE A  96
VAL B  37
ALA B  93
TRP B 103
 None
 0.58A 1h8sA-4j8rA:
21.3		 1h8sA-4j8rA:
53.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		5 / 7 GLY B  53
PRO B  52
THR B  57
ILE B  51
GLY B  55
 None
 1.14A 1usqA-4j8rB:
undetectable		 1usqA-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		4 / 6 GLY B  53
PRO B  52
ILE B  51
GLY B  55
 None
 0.81A 1usqB-4j8rB:
undetectable		 1usqB-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		4 / 6 GLY B  53
PRO B  52
ILE B  51
GLY B  55
 None
 0.81A 1usqC-4j8rB:
undetectable		 1usqC-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		4 / 6 GLY B  53
PRO B  52
ILE B  51
GLY B  55
 None
 0.81A 1usqD-4j8rB:
undetectable		 1usqD-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		4 / 6 GLY B  53
PRO B  52
ILE B  51
GLY B  55
 None
 0.80A 1usqE-4j8rB:
undetectable		 1usqE-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		5 / 12 LEU B 137
VAL B 162
GLY B 156
VAL B 182
VAL B 180
 None
 0.93A 2ieoB-4j8rB:
undetectable		 2ieoB-4j8rB:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		4 / 6 GLY B  53
PRO B  52
ILE B  51
GLY B  55
 None
 0.87A 2jkjA-4j8rB:
undetectable		 2jkjA-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		4 / 6 GLY B  53
PRO B  52
ILE B  51
GLY B  55
 None
 0.87A 2jkjB-4j8rB:
undetectable		 2jkjB-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		4 / 6 GLY B  53
PRO B  52
ILE B  51
GLY B  55
 None
 0.87A 2jkjC-4j8rB:
undetectable		 2jkjC-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		5 / 7 GLY B  53
PRO B  52
THR B  57
ILE B  51
GLY B  55
 None
 1.16A 2jklA-4j8rB:
undetectable		 2jklA-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		5 / 7 GLY B  53
PRO B  52
THR B  57
ILE B  51
GLY B  55
 None
 1.16A 2jklC-4j8rB:
undetectable		 2jklC-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		5 / 7 GLY B  53
PRO B  52
THR B  57
ILE B  51
GLY B  55
 None
 1.15A 2jklD-4j8rB:
undetectable		 2jklD-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		5 / 7 GLY B  53
PRO B  52
THR B  57
ILE B  51
GLY B  55
 None
 1.16A 2jklF-4j8rB:
undetectable		 2jklF-4j8rB:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		5 / 12 VAL B 162
VAL B 180
SER B 178
ASN B 195
ASN B 154
 None
 1.43A 3nyaA-4j8rB:
undetectable		 3nyaA-4j8rB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4j8r HEAVY CHAIN OF POM2
FAB
(Mus
musculus) 		3 / 3 GLY B  65
THR B  68
ASN B  82
 None
 0.70A 5odiG-4j8rB:
undetectable		 5odiG-4j8rB:
16.33