SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLY A 944
ILE A 945
PHE A 974
ALA A 966
LEU A 929
 None
 0.97A 3hs6B-4j8sA:
undetectable		 3hs6B-4j8sA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 GLU A 888
TYR A 895
LEU A 900
PHE A 892
 None
 1.35A 4twdF-4j8sA:
undetectable
4twdG-4j8sA:
undetectable		 4twdF-4j8sA:
21.70
4twdG-4j8sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 6 GLU A 888
TYR A 895
LEU A 900
PHE A 892
 None
 1.27A 4twdI-4j8sA:
undetectable
4twdJ-4j8sA:
undetectable		 4twdI-4j8sA:
21.70
4twdJ-4j8sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ASN A 839
SER A 840
ASP A 836
GLU A 837
ARG A 873
 None
 1.32A 4urnA-4j8sA:
undetectable		 4urnA-4j8sA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ASN A 839
SER A 840
ASP A 836
GLU A 837
ARG A 873
 None
 1.43A 4urnB-4j8sA:
undetectable		 4urnB-4j8sA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 11 ASN A 839
SER A 840
ASP A 836
GLU A 837
ARG A 873
 None
 1.41A 4urnC-4j8sA:
undetectable		 4urnC-4j8sA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU A 885
PHE A 886
LEU A 925
LEU A 921
ALA A 947
 None
 1.36A 5ieoA-4j8sA:
undetectable		 5ieoA-4j8sA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 VAL A 928
VAL A 916
GLY A 908
ALA A 947
LEU A 978
 None
 0.76A 5xxiA-4j8sA:
undetectable		 5xxiA-4j8sA:
18.12