SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 4j8z SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		5 / 9 GLU A 283
ILE A 243
ALA A 276
VAL A 246
MET A 254
 None
 1.14A 1ctrA-4j8zA:
undetectable		 1ctrA-4j8zA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4j8z SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		4 / 6 ILE A 305
ASN A 301
SER A 298
THR A 335
 None
 1.26A 1h7xA-4j8zA:
undetectable		 1h7xA-4j8zA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4j8z SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		4 / 7 TYR A 259
LEU A 282
PHE A 251
VAL A 206
 None
 1.16A 3jwqC-4j8zA:
undetectable		 3jwqC-4j8zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4j8z SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		3 / 3 MET A 255
MET A 288
TYR A 280
 None
 1.27A 4p6xI-4j8zA:
undetectable		 4p6xI-4j8zA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 4j8z SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		3 / 3 ILE A 217
MET A 228
ASP A 201
 None
 0.86A 5h2uA-4j8zA:
undetectable		 5h2uA-4j8zA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4j8z SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 282
GLY A 261
ARG A 221
ARG A 284
 None
 1.35A 6gtqB-4j8zA:
undetectable
6gtqD-4j8zA:
undetectable		 6gtqB-4j8zA:
21.52
6gtqD-4j8zA:
14.07