SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		5 / 12 ILE A  37
LEU A  66
GLY A  13
VAL A  42
ALA A  52
 ADP  A 601 (-3.9A)
None
ADP  A 601 (-3.4A)
None
None
 0.96A 1axwA-4j91A:
undetectable		 1axwA-4j91A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		5 / 12 ILE A  12
ILE A  78
LEU A 113
ILE A 116
HIS A 109
 None
ADP  A 601 (-3.8A)
None
None
None
 1.12A 1bsxA-4j91A:
undetectable		 1bsxA-4j91A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		5 / 12 ILE A  12
ILE A  78
LEU A 113
ILE A 116
HIS A 109
 None
ADP  A 601 (-3.8A)
None
None
None
 1.12A 1bsxB-4j91A:
undetectable		 1bsxB-4j91A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		5 / 12 ILE A  37
LEU A  66
GLY A  13
VAL A  42
ALA A  52
 ADP  A 601 (-3.9A)
None
ADP  A 601 (-3.4A)
None
None
 0.95A 1tlsA-4j91A:
undetectable		 1tlsA-4j91A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		4 / 5 ALA A  49
TYR A  48
ALA A  52
TYR A  45
 None
 1.02A 1xl6A-4j91A:
undetectable
1xl6B-4j91A:
undetectable		 1xl6A-4j91A:
21.79
1xl6B-4j91A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		4 / 4 ALA A  49
TYR A  48
ALA A  52
TYR A  45
 None
 1.08A 2wlkA-4j91A:
undetectable
2wlkB-4j91A:
undetectable		 2wlkA-4j91A:
21.79
2wlkB-4j91A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		5 / 12 GLY A  13
GLY A  15
ILE A  37
ASN A  56
ALA A  57
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.0A)
ADP  A 601 (-3.9A)
ADP  A 601 (-3.8A)
ADP  A 601 (-3.7A)
 1.17A 3ckkA-4j91A:
7.2		 3ckkA-4j91A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		5 / 12 ILE A  12
GLY A  13
VAL A  35
ILE A  37
ALA A  77
 None
ADP  A 601 (-3.4A)
None
ADP  A 601 (-3.9A)
None
 0.65A 3fpjA-4j91A:
5.9		 3fpjA-4j91A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		3 / 3 ASP A 203
HIS A 185
LYS A 184
 None
 1.01A 4qzuD-4j91A:
undetectable		 4qzuD-4j91A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		6 / 12 GLY A  13
GLY A  15
ILE A  21
ILE A  37
ASN A  38
ASN A  56
 ADP  A 601 (-3.4A)
ADP  A 601 (-3.0A)
None
ADP  A 601 (-3.9A)
None
ADP  A 601 (-3.8A)
 1.47A 5fa8A-4j91A:
7.0		 5fa8A-4j91A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		5 / 11 ARG A  16
GLY A  13
GLN A 105
THR A  86
THR A  88
 ADP  A 601 (-3.6A)
ADP  A 601 (-3.4A)
None
None
None
 1.50A 5x19G-4j91A:
undetectable
5x19N-4j91A:
undetectable
5x19O-4j91A:
undetectable		 5x19G-4j91A:
15.49
5x19N-4j91A:
17.38
5x19O-4j91A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A
(Bacillus
subtilis) 		4 / 6 LEU A 162
ASP A 138
GLN A 134
GLU A 218
 None
 1.13A 6djzC-4j91A:
undetectable		 6djzC-4j91A:
20.85