SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 11 ILE A  17
ALA A  69
GLY A  70
GLU A  71
LYS A   3
 None
 1.26A 1n6cA-4j9jA:
undetectable		 1n6cA-4j9jA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 11 ILE A 138
ALA A 190
GLY A 191
GLU A 192
LYS A 124
 None
 1.33A 1n6cA-4j9jA:
undetectable		 1n6cA-4j9jA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 8 ALA A  35
THR A  53
ASN A   7
ILE A  33
 None
 0.83A 2dtjA-4j9jA:
undetectable
2dtjB-4j9jA:
undetectable		 2dtjA-4j9jA:
22.89
2dtjB-4j9jA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 8 ALA A 156
THR A 174
ASN A 128
ILE A 154
 None
 0.79A 2dtjA-4j9jA:
undetectable
2dtjB-4j9jA:
undetectable		 2dtjA-4j9jA:
22.89
2dtjB-4j9jA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 7 GLU A  65
TRP A  60
PRO A  14
GLY A  68
 None
 1.28A 2hs1B-4j9jA:
undetectable		 2hs1B-4j9jA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 7 GLU A 186
TRP A 181
PRO A 135
GLY A 189
 None
 1.19A 2hs1B-4j9jA:
undetectable		 2hs1B-4j9jA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 11 ILE A  17
ALA A  69
GLY A  70
GLU A  71
LYS A   3
 None
 1.27A 4e47A-4j9jA:
undetectable		 4e47A-4j9jA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 11 ILE A  17
ALA A  69
GLY A  70
GLU A  71
LYS A   3
 None
 1.30A 4e47B-4j9jA:
undetectable		 4e47B-4j9jA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 11 ILE A  17
ALA A  69
GLY A  70
GLU A  71
LYS A   3
 None
 1.29A 4e47C-4j9jA:
undetectable		 4e47C-4j9jA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 11 ILE A  17
ALA A  69
GLY A  70
GLU A  71
LYS A   3
 None
 1.29A 4jdsA-4j9jA:
undetectable		 4jdsA-4j9jA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 11 ILE A  17
ALA A  69
GLY A  70
GLU A  71
LYS A   3
 None
 1.31A 4jdsB-4j9jA:
undetectable		 4jdsB-4j9jA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 11 ILE A  17
ALA A  69
GLY A  70
GLU A  71
LYS A   3
 None
 1.28A 4jdsC-4j9jA:
undetectable		 4jdsC-4j9jA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 12 ILE A  17
ALA A  69
GLY A  70
GLU A  71
LYS A   3
 None
 1.28A 4jlgA-4j9jA:
undetectable		 4jlgA-4j9jA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 4 ILE A  33
ASN A   7
ILE A   5
VAL A  30
 None
 1.29A 4uy87-4j9jA:
undetectable		 4uy87-4j9jA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		4 / 6 LYS A 171
THR A 129
THR A 167
TYR A 168
 None
 1.49A 4w5rA-4j9jA:
2.7		 4w5rA-4j9jA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 11 ILE A  17
ALA A  69
GLY A  70
GLU A  71
LYS A   3
 None
 1.26A 5ayfA-4j9jA:
undetectable		 5ayfA-4j9jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF
(Thermotoga
maritima) 		5 / 10 TYR A 207
ALA A   9
ILE A   6
PHE A 235
GLY A 228
 None
 1.09A 5i6xA-4j9jA:
undetectable		 5i6xA-4j9jA:
19.24