SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		4 / 5 HIS A  69
GLU A 386
ALA A  71
SER A 133
 None
 1.40A 1errA-4j9tA:
undetectable
1errB-4j9tA:
undetectable		 1errA-4j9tA:
22.28
1errB-4j9tA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		4 / 8 PHE A 396
ALA A 317
PHE A 318
ILE A 315
 None
 1.00A 1gm7A-4j9tA:
undetectable
1gm7B-4j9tA:
undetectable		 1gm7A-4j9tA:
18.96
1gm7B-4j9tA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 7 GLY A 207
PRO A  70
ASP A  85
SER A 206
HIS A  69
 None
 1.45A 1gxsA-4j9tA:
undetectable
1gxsB-4j9tA:
undetectable		 1gxsA-4j9tA:
20.94
1gxsB-4j9tA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 12 LEU A 212
ARG A 270
SER A 289
ILE A 222
TYR A 296
 None
 1.31A 1ot7B-4j9tA:
undetectable		 1ot7B-4j9tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 10 ASP A  55
LEU A 384
THR A 389
GLY A 390
ARG A 392
 None
 1.05A 1rmtA-4j9tA:
undetectable		 1rmtA-4j9tA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 11 GLU A 265
LEU A 272
SER A 238
HIS A 217
TYR A 240
 None
None
None
GOL  A 501 (-3.6A)
None
 1.42A 2h21B-4j9tA:
undetectable		 2h21B-4j9tA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 12 ALA A  93
GLY A  95
ASN A  97
GLY A  86
ASP A  85
 None
 0.90A 2pkmA-4j9tA:
undetectable		 2pkmA-4j9tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 10 ILE A 222
LEU A 266
ILE A 210
ILE A 314
TYR A 296
 None
 1.14A 2w9sC-4j9tA:
undetectable		 2w9sC-4j9tA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 12 TYR A 370
LEU A 170
HIS A  69
ALA A 205
SER A 259
 None
 1.43A 3apvA-4j9tA:
undetectable		 3apvA-4j9tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 12 TYR A 370
LEU A 170
HIS A  69
ALA A 205
SER A 259
 None
 1.45A 3apvB-4j9tA:
undetectable		 3apvB-4j9tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 10 GLY A 382
TYR A 393
ASN A 395
GLU A 208
ILE A 315
 None
 1.27A 3fw1A-4j9tA:
undetectable		 3fw1A-4j9tA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		4 / 4 PHE A 146
TYR A 240
VAL A 169
LEU A 170
 None
 1.22A 3keeD-4j9tA:
undetectable		 3keeD-4j9tA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 9 GLY A 382
TYR A 393
ASN A 395
GLU A 208
ILE A 315
 None
 1.48A 3owxA-4j9tA:
undetectable		 3owxA-4j9tA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		4 / 8 ALA A 226
PHE A 203
ALA A 276
THR A 309
 None
 0.93A 3t3sD-4j9tA:
undetectable		 3t3sD-4j9tA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		4 / 6 GLY A 382
ASN A 395
GLU A 208
ILE A 315
 None
 0.81A 4fglD-4j9tA:
undetectable		 4fglD-4j9tA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		3 / 3 ARG A 220
HIS A 217
TYR A 240
 GOL  A 501 (-2.7A)
GOL  A 501 (-3.6A)
None
 0.97A 4fu8A-4j9tA:
undetectable		 4fu8A-4j9tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		3 / 3 ARG A 220
HIS A 217
TYR A 240
 GOL  A 501 (-2.7A)
GOL  A 501 (-3.6A)
None
 0.97A 4fu9A-4j9tA:
undetectable		 4fu9A-4j9tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 12 TRP A 357
LEU A 401
ALA A 375
ALA A 317
GLY A 382
 None
 1.06A 4hfpD-4j9tA:
undetectable		 4hfpD-4j9tA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		4 / 7 GLY A 293
ASP A 291
GLY A 251
GLU A 252
 None
GOL  A 501 (-4.7A)
None
None
 0.95A 4koeA-4j9tA:
undetectable
4koeB-4j9tA:
undetectable
4koeD-4j9tA:
undetectable		 4koeA-4j9tA:
21.38
4koeB-4j9tA:
21.38
4koeD-4j9tA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		3 / 3 TYR A 370
ARG A 342
SER A 369
 None
 1.05A 4lf7I-4j9tA:
undetectable
4lf7J-4j9tA:
undetectable		 4lf7I-4j9tA:
20.28
4lf7J-4j9tA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		3 / 3 TYR A 370
ARG A 342
SER A 369
 None
 1.05A 4lf8I-4j9tA:
undetectable
4lf8J-4j9tA:
undetectable		 4lf8I-4j9tA:
20.28
4lf8J-4j9tA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 12 TYR A 296
ASP A 291
ALA A 250
SER A 295
ASP A 242
 None
GOL  A 501 (-4.7A)
None
None
None
 1.35A 4mm4A-4j9tA:
undetectable		 4mm4A-4j9tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		4 / 6 PHE A 396
GLY A 382
TYR A 381
ALA A 375
 None
 1.01A 4yshB-4j9tA:
undetectable		 4yshB-4j9tA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		3 / 3 LEU A 376
TYR A 393
SER A 104
 None
 0.87A 5iktA-4j9tA:
undetectable		 5iktA-4j9tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		3 / 3 HIS A 131
ASP A  85
HIS A  69
 None
 0.94A 5n1tW-4j9tA:
undetectable		 5n1tW-4j9tA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 12 GLU A 208
GLY A 207
VAL A 271
LEU A 272
ILE A 210
 None
 1.15A 5vopB-4j9tA:
undetectable		 5vopB-4j9tA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		3 / 3 THR A 162
THR A 190
ARG A 202
 None
 0.89A 5wm2A-4j9tA:
undetectable		 5wm2A-4j9tA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		4 / 6 GLN A 115
VAL A 117
ALA A 175
THR A 176
 None
 1.01A 6cduB-4j9tA:
undetectable
6cduC-4j9tA:
undetectable		 6cduB-4j9tA:
20.94
6cduC-4j9tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		4 / 5 ILE A 143
THR A  73
THR A 140
LEU A 221
 None
 1.15A 6f3mD-4j9tA:
undetectable		 6f3mD-4j9tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN
(Micromonospora
viridifaciens) 		5 / 12 LEU A 401
GLY A 382
PHE A 396
ASN A 395
ILE A 315
 None
 1.04A 6qxsB-4j9tA:
undetectable		 6qxsB-4j9tA:
21.97