SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4j9w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 5 LEU A 193
ARG A 190
ALA A 192
ILE A 209
 None
 0.97A 2qhfA-4j9wA:
undetectable		 2qhfA-4j9wA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		3 / 3 ALA A  62
THR A  16
CYH A  88
 None
None
PYC  A 402 (-3.7A)
 0.72A 3e4eB-4j9wA:
undetectable		 3e4eB-4j9wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 8 PRO A 115
PRO A 227
VAL A  60
GLY A  61
 None
 0.75A 3em0B-4j9wA:
undetectable		 3em0B-4j9wA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 GLY A  91
VAL A  96
ALA A  74
LEU A  85
THR A 118
 None
None
None
PYC  A 402 ( 4.8A)
None
 1.11A 3mteA-4j9wA:
undetectable		 3mteA-4j9wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 8 GLY A 160
SER A 241
ASP A 232
SER A 234
 None
None
PYC  A 402 (-3.6A)
PYC  A 402 ( 4.4A)
 0.83A 3pwwA-4j9wA:
undetectable		 3pwwA-4j9wA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 4 ALA A 294
VAL A   6
ASP A   8
LEU A  59
 None
 1.44A 4e7gA-4j9wA:
undetectable		 4e7gA-4j9wA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 7 PHE A 269
VAL A 131
GLY A  94
THR A  16
 GOL  A 404 (-4.7A)
None
None
None
 0.88A 4ejjB-4j9wA:
undetectable		 4ejjB-4j9wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		6 / 9 GLY A  89
ASP A 232
SER A 234
CYH A 236
GLY A 237
THR A 238
 PYC  A 402 (-3.6A)
PYC  A 402 (-3.6A)
PYC  A 402 ( 4.4A)
PYC  A 402 (-3.6A)
PYC  A 402 (-3.6A)
PYC  A 402 (-2.7A)
 0.25A 4lb0A-4j9wA:
41.0		 4lb0A-4j9wA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 8 SER A   9
SER A  98
ILE A  20
GLU A 293
 None
 1.34A 4ms4A-4j9wA:
undetectable		 4ms4A-4j9wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 CYH A 246
LEU A 247
LEU A 166
ALA A 136
ALA A 158
 None
 1.14A 4x1iD-4j9wA:
undetectable		 4x1iD-4j9wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 CYH A 246
LEU A 247
LEU A 166
ALA A 136
ALA A 158
 None
 1.07A 4x1kD-4j9wA:
undetectable		 4x1kD-4j9wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 VAL A 119
ALA A 121
PHE A 269
ILE A  93
ASN A 133
 None
None
GOL  A 404 (-4.7A)
None
None
 1.01A 5hgcA-4j9wA:
undetectable		 5hgcA-4j9wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 12 HIS A  90
THR A  11
ASP A 232
GLY A  94
PHE A 269
 PYC  A 402 (-4.1A)
None
PYC  A 402 (-3.6A)
None
GOL  A 404 (-4.7A)
 1.48A 5m66B-4j9wA:
undetectable		 5m66B-4j9wA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		5 / 9 SER A  98
THR A  16
SER A   9
ILE A 290
THR A  11
 None
 1.12A 5muoA-4j9wA:
undetectable
5muoB-4j9wA:
undetectable
5muoC-4j9wA:
undetectable
5muoD-4j9wA:
undetectable
5muoE-4j9wA:
undetectable		 5muoA-4j9wA:
14.54
5muoB-4j9wA:
14.54
5muoC-4j9wA:
14.54
5muoD-4j9wA:
14.54
5muoE-4j9wA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 5 LEU A 284
VAL A 131
MET A  87
CYH A 236
 None
None
None
PYC  A 402 (-3.6A)
 1.42A 5te0A-4j9wA:
undetectable		 5te0A-4j9wA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4j9w PROLINE RACEMASE
FAMILY PROTEIN
(Pseudomonas
protegens) 		4 / 8 LEU A 247
GLU A 210
TRP A 259
ASN A 222
 None
 1.21A 6c71B-4j9wA:
undetectable		 6c71B-4j9wA:
12.89