SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ja0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		5 / 12 ILE A 178
ALA A 182
LYS A  72
PHE A  80
ILE A 175
 None
 0.96A 1cd2A-4ja0A:
2.7		 1cd2A-4ja0A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		5 / 12 SER A 144
GLU A 145
ARG A 169
ILE A 160
THR A 131
 SO4  A 502 (-4.6A)
SO4  A 502 (-4.3A)
None
None
None
 1.33A 1s14A-4ja0A:
undetectable		 1s14A-4ja0A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		3 / 3 TYR A 233
GLU A  54
THR A  21
 None
None
SO4  A 505 (-3.6A)
 0.99A 2y7hB-4ja0A:
undetectable		 2y7hB-4ja0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		5 / 12 SER A 144
GLU A 145
ARG A 169
ILE A 160
THR A 131
 SO4  A 502 (-4.6A)
SO4  A 502 (-4.3A)
None
None
None
 1.29A 3lpsA-4ja0A:
undetectable		 3lpsA-4ja0A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		4 / 7 PHE A 133
ILE A 160
TYR A 155
PRO A  98
 None
 1.13A 4g5jA-4ja0A:
undetectable		 4g5jA-4ja0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		5 / 12 ILE A 178
ALA A 182
LYS A  72
LEU A 207
ILE A 175
 None
 1.04A 4kjkA-4ja0A:
undetectable		 4kjkA-4ja0A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		5 / 12 PRO A 347
ALA A 323
ILE A 285
HIS A 281
LEU A 385
 None
 1.17A 4l9qB-4ja0A:
2.1		 4l9qB-4ja0A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		4 / 6 ASP A 214
ASN A 250
ALA A 252
ASP A 212
 None
 0.83A 4mdaA-4ja0A:
undetectable		 4mdaA-4ja0A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		5 / 11 SER A 144
GLU A 145
ARG A 169
ILE A 160
THR A 131
 SO4  A 502 (-4.6A)
SO4  A 502 (-4.3A)
None
None
None
 1.46A 4urnA-4ja0A:
undetectable		 4urnA-4ja0A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		5 / 11 SER A 144
GLU A 145
ARG A 169
ILE A 160
THR A 131
 SO4  A 502 (-4.6A)
SO4  A 502 (-4.3A)
None
None
None
 1.46A 4urnB-4ja0A:
undetectable		 4urnB-4ja0A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		5 / 11 SER A 144
GLU A 145
ARG A 169
ILE A 160
THR A 131
 SO4  A 502 (-4.6A)
SO4  A 502 (-4.3A)
None
None
None
 1.43A 4urnC-4ja0A:
undetectable		 4urnC-4ja0A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		5 / 12 SER A 144
GLU A 145
ARG A 169
ILE A 160
THR A 131
 SO4  A 502 (-4.6A)
SO4  A 502 (-4.3A)
None
None
None
 1.33A 4uroD-4ja0A:
undetectable		 4uroD-4ja0A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		4 / 6 ASP A 212
ALA A  57
LYS A  39
THR A  21
 None
None
None
SO4  A 505 (-3.6A)
 1.43A 4w5qA-4ja0A:
6.3		 4w5qA-4ja0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		4 / 6 ASP A 212
ALA A  57
LYS A  39
THR A  21
 None
None
None
SO4  A 505 (-3.6A)
 1.43A 4w5rA-4ja0A:
6.4		 4w5rA-4ja0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		4 / 6 ASP A 212
ALA A  57
LYS A  39
THR A  21
 None
None
None
SO4  A 505 (-3.6A)
 1.42A 4w5tA-4ja0A:
6.2		 4w5tA-4ja0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		4 / 6 ASP A 212
ALA A  57
LYS A  39
THR A  21
 None
None
None
SO4  A 505 (-3.6A)
 1.37A 4z4cA-4ja0A:
6.3		 4z4cA-4ja0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4ja0 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bombyx
mori) 		4 / 4 VAL A 210
ALA A 208
PHE A  68
THR A  78
 None
 1.40A 4z4fA-4ja0A:
undetectable		 4z4fA-4ja0A:
21.25