SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jb7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		3 / 3 TRP A 197
VAL A 195
TRP A 191
 None
 1.08A 1c4dA-4jb7A:
undetectable
1c4dB-4jb7A:
undetectable		 1c4dA-4jb7A:
5.71
1c4dB-4jb7A:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		4 / 7 VAL A 101
LEU A  38
VAL A  41
LEU A 224
 None
 0.67A 1cqpA-4jb7A:
undetectable
1cqpB-4jb7A:
2.5		 1cqpA-4jb7A:
20.85
1cqpB-4jb7A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		4 / 6 VAL A 152
LEU A 161
ARG A 165
PHE A 164
 None
 1.05A 1s8fB-4jb7A:
undetectable		 1s8fB-4jb7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		5 / 9 PHE A 220
VAL A 222
PHE A 102
SER A 242
LEU A  38
 None
 1.17A 1wrkA-4jb7A:
undetectable
1wrkB-4jb7A:
undetectable		 1wrkA-4jb7A:
15.51
1wrkB-4jb7A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		5 / 10 PHE A 102
PRO A  37
VAL A 222
TYR A 238
PHE A 236
 None
 1.42A 2d06B-4jb7A:
undetectable		 2d06B-4jb7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		4 / 7 PHE A  75
GLY A  76
PHE A 220
PHE A 249
 None
 0.97A 3ko0D-4jb7A:
undetectable
3ko0E-4jb7A:
undetectable		 3ko0D-4jb7A:
17.49
3ko0E-4jb7A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		4 / 8 PHE A  75
GLY A  76
PHE A 220
PHE A 249
 None
 0.91A 3ko0O-4jb7A:
undetectable
3ko0Q-4jb7A:
undetectable		 3ko0O-4jb7A:
17.49
3ko0Q-4jb7A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		4 / 8 PHE A 249
ILE A  55
PHE A  75
VAL A  53
 None
TRS  A 302 (-4.3A)
None
None
 0.82A 3me6B-4jb7A:
undetectable		 3me6B-4jb7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		5 / 12 ALA A  82
LEU A  38
PRO A  37
LEU A 239
ILE A  73
 None
 0.87A 4m2xC-4jb7A:
undetectable		 4m2xC-4jb7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		5 / 12 LEU A 239
ALA A  42
LEU A  28
ASN A  54
LYS A   0
 None
TRS  A 302 ( 4.3A)
None
TRS  A 302 (-4.5A)
None
 1.10A 4x1yB-4jb7A:
undetectable		 4x1yB-4jb7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		5 / 11 LEU A 224
VAL A 223
PHE A 220
GLY A  76
LEU A  28
 None
 1.30A 4zbqA-4jb7A:
undetectable		 4zbqA-4jb7A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC
(Vibrio
cholerae) 		5 / 11 LEU A 224
VAL A 223
PHE A 220
LEU A  38
GLY A  76
 None
 1.03A 4zbqA-4jb7A:
undetectable		 4zbqA-4jb7A:
18.47