SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jbe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
3 / 3 ALA A 287
VAL A 282
TRP A 279
ALA  A 287 ( 0.0A)
VAL  A 282 ( 0.6A)
TRP  A 279 ( 0.5A)
0.86A 1av2C-4jbeA:
undetectable
1av2D-4jbeA:
undetectable
1av2C-4jbeA:
7.36
1av2D-4jbeA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
4 / 8 ILE A 205
ASN A 144
GLY A 122
LEU A 148
ILE  A 205 ( 0.7A)
ASN  A 144 ( 0.6A)
GLY  A 122 ( 0.0A)
LEU  A 148 ( 0.5A)
0.98A 1dzmA-4jbeA:
undetectable
1dzmA-4jbeA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
3 / 3 ARG A 348
ILE A 342
TRP A 364
ARG  A 348 ( 0.6A)
ILE  A 342 ( 0.7A)
TRP  A 364 ( 0.5A)
1.22A 1m8eB-4jbeA:
undetectable
1m8eB-4jbeA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
3 / 3 ALA A 287
VAL A 282
TRP A 279
ALA  A 287 ( 0.0A)
VAL  A 282 ( 0.6A)
TRP  A 279 ( 0.5A)
0.91A 1nrmA-4jbeA:
undetectable
1nrmA-4jbeA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
3 / 3 ALA A 287
VAL A 282
TRP A 279
ALA  A 287 ( 0.0A)
VAL  A 282 ( 0.6A)
TRP  A 279 ( 0.5A)
0.91A 1nrmB-4jbeA:
undetectable
1nrmB-4jbeA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
3 / 3 ALA A 287
VAL A 282
TRP A 279
ALA  A 287 ( 0.0A)
VAL  A 282 ( 0.6A)
TRP  A 279 ( 0.5A)
0.92A 1nruA-4jbeA:
undetectable
1nruA-4jbeA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
3 / 3 ALA A 287
VAL A 282
TRP A 279
ALA  A 287 ( 0.0A)
VAL  A 282 ( 0.6A)
TRP  A 279 ( 0.5A)
0.92A 1nruB-4jbeA:
undetectable
1nruB-4jbeA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
4 / 7 VAL A 239
VAL A 236
TYR A 304
ARG A 249
VAL  A 239 ( 0.6A)
VAL  A 236 ( 0.6A)
TYR  A 304 ( 1.3A)
ARG  A 249 ( 0.6A)
1.21A 1t46A-4jbeA:
undetectable
1t46A-4jbeA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
3 / 3 SER A 209
GLY A 208
ARG A  72
SER  A 209 (-0.0A)
GLY  A 208 (-0.0A)
ARG  A  72 ( 0.6A)
0.52A 1t9wA-4jbeA:
undetectable
1t9wA-4jbeA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
5 / 10 ALA A  34
LEU A 162
SER A 173
LEU A 170
ARG A  41
ALA  A  34 ( 0.0A)
LEU  A 162 ( 0.6A)
SER  A 173 ( 0.0A)
LEU  A 170 ( 0.6A)
ARG  A  41 ( 0.6A)
1.35A 2ceoB-4jbeA:
undetectable
2ceoB-4jbeA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
4 / 6 LEU A 206
VAL A 179
VAL A 201
ARG A 143
LEU  A 206 ( 0.6A)
VAL  A 179 ( 0.6A)
VAL  A 201 ( 0.6A)
ARG  A 143 ( 0.6A)
0.84A 2hyyA-4jbeA:
undetectable
2hyyA-4jbeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
5 / 12 VAL A 133
ILE A 175
ALA A  34
LEU A  35
LEU A  87
VAL  A 133 ( 0.6A)
ILE  A 175 ( 0.7A)
ALA  A  34 ( 0.0A)
LEU  A  35 ( 0.5A)
LEU  A  87 ( 0.6A)
0.76A 3n8yB-4jbeA:
undetectable
3n8yB-4jbeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
3 / 3 ARG A 348
ILE A 342
TRP A 364
ARG  A 348 ( 0.6A)
ILE  A 342 ( 0.7A)
TRP  A 364 ( 0.5A)
1.08A 3nw2A-4jbeA:
undetectable
3nw2A-4jbeA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
5 / 12 ALA A 123
LEU A 182
ILE A 166
LEU A 162
LEU A 139
ALA  A 123 ( 0.0A)
LEU  A 182 ( 0.6A)
ILE  A 166 ( 0.7A)
LEU  A 162 ( 0.6A)
LEU  A 139 ( 0.6A)
1.20A 4j24D-4jbeA:
undetectable
4j24D-4jbeA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
5 / 12 GLY A 122
ALA A  13
ALA A 145
LEU A 206
ALA A 220
GLY  A 122 ( 0.0A)
ALA  A  13 ( 0.0A)
ALA  A 145 ( 0.0A)
LEU  A 206 ( 0.6A)
ALA  A 220 ( 0.0A)
0.99A 5bw4B-4jbeA:
3.2
5bw4B-4jbeA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
4 / 6 PRO A 129
VAL A 133
VAL A 165
ILE A  75
PRO  A 129 ( 1.1A)
VAL  A 133 ( 0.6A)
VAL  A 165 ( 0.6A)
ILE  A  75 ( 0.7A)
0.91A 5pbeA-4jbeA:
undetectable
5pbeA-4jbeA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
5 / 10 ILE A 166
LEU A 162
ASN A  53
LEU A 155
ALA A 154
ILE  A 166 ( 0.7A)
LEU  A 162 ( 0.6A)
ASN  A  53 ( 0.6A)
LEU  A 155 ( 0.5A)
ALA  A 154 ( 0.0A)
1.06A 5y7pB-4jbeA:
undetectable
5y7pB-4jbeA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
5 / 10 ILE A 166
LEU A 162
ASN A  53
LEU A 155
ALA A 154
ILE  A 166 ( 0.7A)
LEU  A 162 ( 0.6A)
ASN  A  53 ( 0.6A)
LEU  A 155 ( 0.5A)
ALA  A 154 ( 0.0A)
1.03A 5y7pD-4jbeA:
undetectable
5y7pD-4jbeA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
5 / 10 ILE A 166
LEU A 162
ASN A  53
LEU A 155
ALA A 154
ILE  A 166 ( 0.7A)
LEU  A 162 ( 0.6A)
ASN  A  53 ( 0.6A)
LEU  A 155 ( 0.5A)
ALA  A 154 ( 0.0A)
1.00A 5y7pH-4jbeA:
undetectable
5y7pH-4jbeA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospor
a
viridis)
5 / 10 ARG A  98
ALA A  34
HIS A  95
LEU A  23
VAL A 140
ARG  A  98 (-0.6A)
ALA  A  34 ( 0.0A)
HIS  A  95 ( 1.0A)
LEU  A  23 ( 0.5A)
VAL  A 140 ( 0.6A)
1.28A 5zbdA-4jbeA:
1.6
5zbdA-4jbeA:
24.31