SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		4 / 5 SER A 203
SER A 207
VAL A 324
PHE A 301
 None
 1.22A 1oipA-4jbhA:
undetectable		 1oipA-4jbhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 PHE A  63
GLY A  37
ILE A 147
VAL A 311
PRO A  59
 None
 1.20A 1sg9A-4jbhA:
6.5		 1sg9A-4jbhA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 GLY A 245
VAL A 275
LEU A 274
GLY A 248
GLY A 247
 None
 0.85A 1uakA-4jbhA:
undetectable		 1uakA-4jbhA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		4 / 5 LEU A 205
PHE A 301
VAL A 181
ALA A 172
 None
 0.84A 2cizA-4jbhA:
undetectable		 2cizA-4jbhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 10 PRO A  54
HIS A  57
ALA A  19
VAL A  17
MET A   1
 None
 1.28A 2d06A-4jbhA:
0.0		 2d06A-4jbhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 10 PRO A  54
HIS A  57
ALA A  19
VAL A  17
MET A   1
 None
 1.40A 2d06B-4jbhA:
undetectable		 2d06B-4jbhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 ALA A  36
LEU A 139
VAL A  38
GLY A  60
PRO A 331
 None
 1.13A 2f8lA-4jbhA:
7.5		 2f8lA-4jbhA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		4 / 6 THR A 252
THR A 232
ASN A  39
ASP A  42
 None
 1.22A 2okcA-4jbhA:
7.5		 2okcA-4jbhA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 LEU A 244
ALA A 168
VAL A 167
THR A 252
ASP A 230
 None
 1.40A 2qo4A-4jbhA:
undetectable		 2qo4A-4jbhA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		4 / 7 GLY A  60
ALA A 125
ALA A 122
VAL A 127
 None
 0.73A 3a2qA-4jbhA:
undetectable		 3a2qA-4jbhA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		4 / 8 GLY A 120
GLY A 119
GLY A 114
ILE A 112
 None
 0.65A 3d41A-4jbhA:
2.2		 3d41A-4jbhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 GLY A  60
GLY A 120
ALA A 125
ALA A   4
ILE A 113
 None
 0.98A 3jayA-4jbhA:
undetectable		 3jayA-4jbhA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		4 / 7 GLU A 294
VAL A 289
VAL A  84
ALA A 142
 None
 0.96A 3kp6B-4jbhA:
undetectable		 3kp6B-4jbhA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		6 / 12 ALA A 314
LEU A 318
GLY A  37
LYS A 140
TYR A  35
ALA A 300
 None
 1.37A 3tm4A-4jbhA:
8.9		 3tm4A-4jbhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		6 / 12 ALA A 314
LEU A 318
GLY A  37
LYS A 140
TYR A  35
ALA A 300
 None
 1.39A 3tm4B-4jbhA:
8.9		 3tm4B-4jbhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 11 SER A 203
LEU A 205
SER A 207
VAL A 324
PHE A 301
 None
 1.02A 3w67A-4jbhA:
undetectable		 3w67A-4jbhA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 SER A 203
LEU A 205
SER A 207
VAL A 324
PHE A 301
 None
 1.18A 3w68A-4jbhA:
undetectable		 3w68A-4jbhA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		4 / 7 VAL A 191
VAL A 169
LEU A 229
VAL A 176
 None
 1.09A 4e1gB-4jbhA:
undetectable		 4e1gB-4jbhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		4 / 7 ALA A  52
GLY A 111
ILE A 113
GLY A 114
 None
 0.67A 4eatA-4jbhA:
5.1		 4eatA-4jbhA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 LEU A 244
GLY A 242
PHE A 241
VAL A 228
ALA A 168
 None
 1.23A 4fqsA-4jbhA:
undetectable		 4fqsA-4jbhA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 LEU A 244
GLY A 242
PHE A 241
VAL A 228
ALA A 168
 None
 1.25A 4fqsB-4jbhA:
undetectable		 4fqsB-4jbhA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 VAL A 213
GLY A 209
ALA A 208
ILE A 204
VAL A 324
 None
 0.87A 4xdrA-4jbhA:
undetectable		 4xdrA-4jbhA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 GLY A 100
PHE A  63
GLY A 120
GLY A 114
LEU A  89
 None
 1.01A 5eqbA-4jbhA:
undetectable		 5eqbA-4jbhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		3 / 3 GLY A  92
CYH A  97
CYH A  94
 ZN  A 401 ( 4.8A)
ZN  A 401 ( 2.2A)
ZN  A 401 ( 2.2A)
 0.96A 5inzB-4jbhA:
undetectable		 5inzB-4jbhA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 11 VAL A 167
GLU A 165
SER A 162
ALA A 184
LEU A 229
 None
 1.08A 5x6yA-4jbhA:
3.3		 5x6yA-4jbhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4jbh ALCOHOL
DEHYDROGENASE (ZINC)
(Pyrobaculum
aerophilum) 		5 / 12 GLY A 245
VAL A 275
LEU A 274
GLY A 248
GLY A 247
 None
 0.85A 5zhmB-4jbhA:
undetectable		 5zhmB-4jbhA:
24.93