SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4jc2 ASFP504
(Alcyonium) 		5 / 11 ILE A  56
ASP A 121
GLY A 122
PHE A 125
VAL A 103
 None
 1.35A 1axwB-4jc2A:
undetectable		 1axwB-4jc2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4jc2 ASFP504
(Alcyonium) 		4 / 6 TYR A  87
GLU A 144
ILE A 118
TYR A 116
 None
CRQ  A  64 ( 4.9A)
None
CRQ  A  64 ( 4.6A)
 1.04A 1maaB-4jc2A:
undetectable
1maaD-4jc2A:
undetectable		 1maaB-4jc2A:
16.76
1maaD-4jc2A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4jc2 ASFP504
(Alcyonium) 		3 / 3 ARG A  66
ILE A 107
TRP A  89
 CRQ  A  64 ( 4.3A)
None
CRQ  A  64 ( 3.9A)
 1.09A 1nodB-4jc2A:
undetectable		 1nodB-4jc2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4jc2 ASFP504
(Alcyonium) 		4 / 4 ASP A  55
LEU A 162
LEU A 137
LEU A 161
 None
 1.23A 1u18A-4jc2A:
undetectable		 1u18A-4jc2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 4jc2 ASFP504
(Alcyonium) 		5 / 11 ILE A  56
ASP A 121
GLY A 122
PHE A 125
VAL A 103
 None
 1.35A 4fogC-4jc2A:
undetectable		 4fogC-4jc2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4jc2 ASFP504
(Alcyonium) 		4 / 7 ASN A 195
ALA A  59
VAL A 157
ARG A  91
 CRQ  A  64 ( 3.3A)
CRQ  A  64 ( 3.9A)
None
CRQ  A  64 ( 3.0A)
 1.14A 4ijiH-4jc2A:
undetectable		 4ijiH-4jc2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4jc2 ASFP504
(Alcyonium) 		5 / 12 GLU A 211
ARG A  66
MET A  14
GLY A  27
LEU A  42
 CRQ  A  64 ( 3.8A)
CRQ  A  64 ( 4.3A)
None
None
None
 1.18A 5gs4A-4jc2A:
undetectable		 5gs4A-4jc2A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4jc2 ASFP504
(Alcyonium) 		4 / 6 PHE A 125
ILE A 100
ASN A  98
ASP A  97
 None
 1.36A 6dhbA-4jc2A:
undetectable		 6dhbA-4jc2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4jc2 ASFP504
(Alcyonium) 		4 / 6 LEU A 219
TYR A  71
ASP A  74
GLN A 184
 None
 1.34A 6djzC-4jc2A:
undetectable		 6djzC-4jc2A:
20.32