SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 10 GLY A 184
PHE A 186
SER A 227
PHE A 605
THR A 603
 None
 1.34A 1a8uA-4jc8A:
undetectable		 1a8uA-4jc8A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 12 ILE A 234
ILE A 612
LEU A 172
LEU A 176
ILE A 235
 None
 0.96A 1df7A-4jc8A:
undetectable		 1df7A-4jc8A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 12 ASP A 314
TYR A 309
GLY A 304
VAL A 148
ALA A 618
 None
 1.11A 1e3vA-4jc8A:
undetectable		 1e3vA-4jc8A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 9 ILE A  35
PHE A 142
VAL A  47
GLY A  44
LEU A  20
 None
 1.21A 1e7aB-4jc8A:
undetectable		 1e7aB-4jc8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 12 ILE A 370
ILE A 366
GLU A 253
ILE A 640
ASN A 265
 None
 0.97A 1jtxA-4jc8A:
2.8		 1jtxA-4jc8A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 12 LEU A 501
LEU A 538
VAL A 243
TYR A 492
ASP A 241
 None
 1.47A 1mrlB-4jc8A:
undetectable
1mrlC-4jc8A:
undetectable		 1mrlB-4jc8A:
15.59
1mrlC-4jc8A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 5 LEU A 250
VAL A 517
TYR A 518
THR A 251
 None
 1.31A 1nw3A-4jc8A:
2.8		 1nw3A-4jc8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 12 ILE A 640
ILE A 612
ARG A 621
ASP A 147
ALA A   9
 None
 1.24A 2qmjA-4jc8A:
undetectable		 2qmjA-4jc8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 5 GLN A  11
PHE A   7
PHE A 605
GLY A 178
 None
 1.16A 2qmzA-4jc8A:
4.2
2qmzB-4jc8A:
4.0		 2qmzA-4jc8A:
16.87
2qmzB-4jc8A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 7 GLY A 254
ILE A 374
THR A 378
LEU A 250
 None
 0.86A 2xrhA-4jc8A:
undetectable		 2xrhA-4jc8A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 10 PHE A 157
ASN A 154
GLY A 610
PRO A 245
MET A 465
 None
 1.05A 2y6rA-4jc8A:
undetectable		 2y6rA-4jc8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 8 ARG A 621
PHE A 614
GLY A 254
GLY A 304
 None
 0.88A 2y6rB-4jc8A:
undetectable		 2y6rB-4jc8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 8 PHE A 157
GLY A 610
PRO A 245
MET A 465
 None
 0.92A 2y6rB-4jc8A:
undetectable		 2y6rB-4jc8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 12 ILE A 526
ALA A 522
ALA A 515
VAL A 606
ILE A 635
 None
 1.01A 3e00A-4jc8A:
undetectable		 3e00A-4jc8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 12 LEU A 172
VAL A 607
ILE A 612
GLY A 611
TYR A 161
 None
 1.38A 3hgiA-4jc8A:
undetectable		 3hgiA-4jc8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		3 / 3 PRO A 187
LEU A 185
GLN A 581
 None
 0.63A 3hznG-4jc8A:
undetectable
3hznH-4jc8A:
undetectable		 3hznG-4jc8A:
16.01
3hznH-4jc8A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		3 / 3 ASN A 264
ASP A  38
ARG A 238
 None
 0.95A 3k13C-4jc8A:
undetectable		 3k13C-4jc8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		3 / 3 ASN A 264
ASP A  38
ARG A 421
 None
 0.87A 3k13C-4jc8A:
undetectable		 3k13C-4jc8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 10 ILE A  78
ASN A  59
LEU A  20
LEU A  52
VAL A  57
 None
 1.19A 3o02A-4jc8A:
2.1
3o02B-4jc8A:
undetectable		 3o02A-4jc8A:
19.70
3o02B-4jc8A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 8 ARG A 621
PHE A 614
GLY A 254
GLY A 304
 None
 0.88A 3v3nB-4jc8A:
undetectable		 3v3nB-4jc8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 8 ARG A 621
PHE A 614
GLY A 254
GLY A 304
 None
 0.89A 3v3nC-4jc8A:
undetectable		 3v3nC-4jc8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 12 PHE A 157
ASN A 154
GLY A 610
PRO A 245
MET A 465
 None
 1.01A 3v3oB-4jc8A:
undetectable		 3v3oB-4jc8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 4 LEU A 255
ILE A 617
TYR A 309
TYR A 518
 None
 1.18A 3vt7A-4jc8A:
undetectable		 3vt7A-4jc8A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 6 ASP A 487
ASP A 201
ASN A 195
GLU A 239
 None
 1.28A 3vywA-4jc8A:
3.0		 3vywA-4jc8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 5 ASP A 487
ASP A 201
ASN A 195
GLU A 239
 None
 1.24A 3vywD-4jc8A:
2.9		 3vywD-4jc8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 11 PHE A 157
ASN A 154
PRO A 245
GLY A 643
MET A 465
 None
 1.20A 4a6nA-4jc8A:
undetectable		 4a6nA-4jc8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 11 PHE A 157
ASN A 154
PRO A 245
GLY A 643
MET A 465
 None
 1.21A 4a6nB-4jc8A:
undetectable		 4a6nB-4jc8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 11 PHE A 157
ASN A 154
PRO A 245
GLY A 643
MET A 465
 None
 1.20A 4a6nC-4jc8A:
undetectable		 4a6nC-4jc8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 5 HIS A 108
LEU A  52
LEU A  21
ASP A  54
 None
 1.12A 4aqlA-4jc8A:
3.8		 4aqlA-4jc8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 9 GLY A  81
PRO A 113
PRO A  42
GLU A 152
TYR A 140
 None
 1.30A 4fimA-4jc8A:
undetectable		 4fimA-4jc8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		3 / 3 GLU A 505
ASP A 504
ASP A 513
 None
 0.63A 4gc9A-4jc8A:
2.7		 4gc9A-4jc8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 12 ILE A 234
ILE A 612
LEU A 172
LEU A 176
ILE A 235
 None
 1.07A 4m2xE-4jc8A:
undetectable		 4m2xE-4jc8A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		3 / 3 THR A 613
ASN A 316
PHE A 317
 None
 0.81A 4pd9A-4jc8A:
2.0		 4pd9A-4jc8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		3 / 3 LEU A 331
ASP A 334
TYR A 335
 None
 0.65A 4qc6B-4jc8A:
undetectable		 4qc6B-4jc8A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 7 GLU A 381
SER A 405
GLU A 388
ASP A 398
 None
 1.08A 4uacA-4jc8A:
undetectable		 4uacA-4jc8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 6 LEU A  39
LEU A  20
ILE A 109
PHE A 110
 None
 1.22A 4y4dA-4jc8A:
undetectable		 4y4dA-4jc8A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		3 / 3 SER A 540
GLU A 505
GLU A 508
 None
 0.81A 4ymgB-4jc8A:
2.7		 4ymgB-4jc8A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		3 / 3 LEU A 528
PHE A 608
ILE A 526
 None
 0.75A 5dzk1-4jc8A:
undetectable
5dzkF-4jc8A:
undetectable
5dzkM-4jc8A:
undetectable		 5dzk1-4jc8A:
8.70
5dzkF-4jc8A:
14.71
5dzkM-4jc8A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 12 ILE A 262
GLY A 261
ASP A 303
SER A 363
ILE A 366
 None
 1.38A 5igwA-4jc8A:
undetectable		 5igwA-4jc8A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 7 ASP A 510
PRO A 511
TYR A 516
SER A 322
 None
 1.24A 5l1fC-4jc8A:
3.0		 5l1fC-4jc8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 6 PRO A 168
LEU A 171
PHE A 170
LEU A 160
 None
 1.14A 5tl8A-4jc8A:
0.6		 5tl8A-4jc8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 8 GLY A 520
GLN A 626
VAL A 506
ASP A 513
 None
 1.08A 5vlmA-4jc8A:
3.0		 5vlmA-4jc8A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		3 / 3 GLN A 464
ILE A 651
HIS A 453
 None
 0.70A 5z12B-4jc8A:
undetectable		 5z12B-4jc8A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 7 ASN A 316
ALA A 315
GLU A 253
LEU A 250
 None
 1.09A 6ci6A-4jc8A:
3.1		 6ci6A-4jc8A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		5 / 10 ARG A 621
ALA A 618
GLY A 254
ASP A 257
ARG A 645
 None
 1.40A 6clxB-4jc8A:
4.4		 6clxB-4jc8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4jc8 HOPS COMPONENT VPS33
(Chaetomium
thermophilum) 		4 / 6 VAL A 419
LEU A 460
LEU A 457
HIS A 453
 None
 1.01A 6e43D-4jc8A:
undetectable		 6e43D-4jc8A:
20.23