SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jcc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 262
GLU A 205
ASP A 272
LEU A 203
GLY A 206
 None
 1.47A 1d4fD-4jccA:
undetectable		 1d4fD-4jccA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 PHE A 244
LEU A 199
VAL A 257
MET A 208
 None
 1.09A 1gsfA-4jccA:
undetectable		 1gsfA-4jccA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 PHE A 244
LEU A 199
VAL A 257
MET A 208
 None
 1.09A 1gsfB-4jccA:
undetectable		 1gsfB-4jccA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 PHE A 244
LEU A 199
VAL A 257
MET A 208
 None
 1.10A 1gsfD-4jccA:
undetectable		 1gsfD-4jccA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PRO A 252
ALA A 210
PHE A 233
SER A 246
 None
 1.03A 1lqtA-4jccA:
2.7		 1lqtA-4jccA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PRO A 252
ALA A 210
PHE A 233
SER A 246
 None
 1.04A 1lquA-4jccA:
2.7		 1lquA-4jccA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A  66
SER A 308
LEU A 161
SER A 160
LEU A 177
 None
 0.87A 1ya4A-4jccA:
undetectable		 1ya4A-4jccA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A  66
SER A 308
LEU A 161
SER A 160
LEU A 177
 None
 0.96A 1ya4B-4jccA:
undetectable		 1ya4B-4jccA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A  66
SER A 308
LEU A 161
SER A 160
LEU A 177
 None
 0.93A 1ya4C-4jccA:
undetectable		 1ya4C-4jccA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 LEU A  65
VAL A  88
THR A  85
VAL A  99
VAL A  96
 None
None
SO4  A 404 ( 4.7A)
None
None
 1.38A 2l8mA-4jccA:
undetectable		 2l8mA-4jccA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 PHE A 244
VAL A 247
ILE A 291
VAL A 257
 None
 0.75A 3hjoB-4jccA:
1.3		 3hjoB-4jccA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 TYR A  91
ASP A  64
ASP A  69
 None
 0.71A 3r24A-4jccA:
undetectable		 3r24A-4jccA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 SER A  46
LYS A  45
LEU A  48
ASP A  49
 None
 1.42A 4ifxA-4jccA:
undetectable		 4ifxA-4jccA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 SER A  46
LYS A  45
LEU A  48
ASP A  49
 None
 1.42A 4ig1A-4jccA:
undetectable		 4ig1A-4jccA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 LYS A 179
LEU A 180
GLU A 176
LEU A 306
 None
 1.37A 4k4yA-4jccA:
undetectable		 4k4yA-4jccA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 LYS A 179
LEU A 180
GLU A 176
LEU A 306
 None
 1.40A 4k4yE-4jccA:
undetectable		 4k4yE-4jccA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 294
ALA A 209
ILE A 254
LEU A 275
GLY A 289
 None
 1.24A 4l9qB-4jccA:
undetectable		 4l9qB-4jccA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A 308
TYR A  91
ASP A  64
 None
 0.86A 4rp8C-4jccA:
undetectable		 4rp8C-4jccA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 LEU A 161
SER A 160
ILE A  44
VAL A  51
 None
 1.23A 4tvtA-4jccA:
undetectable		 4tvtA-4jccA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 THR A 154
GLY A  66
ASN A 157
SER A 302
THR A 295
 None
 1.05A 4uckB-4jccA:
undetectable		 4uckB-4jccA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 SER A  46
LYS A  45
LEU A  48
ASP A  49
 None
 1.39A 4xdtA-4jccA:
undetectable		 4xdtA-4jccA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 LEU A 301
TYR A 300
THR A  87
ASN A 204
 None
 0.99A 6c71B-4jccA:
undetectable		 6c71B-4jccA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ARG A 260
HIS A 238
ARG A 216
 None
 0.93A 6dwdD-4jccA:
undetectable		 6dwdD-4jccA:
19.48