SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jcn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		4 / 8 GLY A 175
ILE A 174
ASN A 168
GLN A 172
 None
 0.90A 2a8tB-4jcnA:
undetectable		 2a8tB-4jcnA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 10 ILE A 162
ALA A 161
ILE A 183
PRO A 277
ILE A 279
 None
 1.07A 2dm6A-4jcnA:
undetectable
2dm6B-4jcnA:
undetectable		 2dm6A-4jcnA:
19.25
2dm6B-4jcnA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.86A 2pxcA-4jcnA:
undetectable		 2pxcA-4jcnA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 124
ILE A  93
ASN A 128
VAL A 118
LEU A 163
 None
 1.21A 2zzmA-4jcnA:
undetectable		 2zzmA-4jcnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 10 GLY A 124
ILE A  93
ASN A 128
VAL A 118
LEU A 163
 None
 1.21A 3ay0B-4jcnA:
undetectable		 3ay0B-4jcnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.86A 3p97A-4jcnA:
undetectable		 3p97A-4jcnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 HIS A 117
ASP A 159
ARG A 225
GLY A 232
SER A 235
 None
 0.86A 3sueB-4jcnA:
12.3		 3sueB-4jcnA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.85A 4ctjA-4jcnA:
undetectable		 4ctjA-4jcnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.84A 4ctkA-4jcnA:
undetectable		 4ctkA-4jcnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		4 / 8 ILE A 249
ALA A  87
VAL A 246
VAL A 197
 None
 0.84A 4jltA-4jcnA:
undetectable		 4jltA-4jcnA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.81A 5e9qA-4jcnA:
undetectable		 5e9qA-4jcnA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.79A 5ec8A-4jcnA:
undetectable		 5ec8A-4jcnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.81A 5ehgA-4jcnA:
undetectable		 5ehgA-4jcnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.96A 5ehgC-4jcnA:
undetectable		 5ehgC-4jcnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.82A 5ehiA-4jcnA:
undetectable		 5ehiA-4jcnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.99A 5ehiC-4jcnA:
undetectable		 5ehiC-4jcnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.85A 5eifA-4jcnA:
undetectable		 5eifA-4jcnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.79A 5eiwA-4jcnA:
undetectable		 5eiwA-4jcnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.82A 5ekxA-4jcnA:
undetectable		 5ekxA-4jcnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.87A 5ekxB-4jcnA:
undetectable		 5ekxB-4jcnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.92A 5kqrA-4jcnA:
undetectable		 5kqrA-4jcnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.91A 5kqsA-4jcnA:
undetectable		 5kqsA-4jcnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.90A 5njvB-4jcnA:
undetectable		 5njvB-4jcnA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 1.02A 5njvD-4jcnA:
undetectable		 5njvD-4jcnA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.89A 5vimA-4jcnA:
undetectable		 5vimA-4jcnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.89A 5vimB-4jcnA:
undetectable		 5vimB-4jcnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.86A 5wz2A-4jcnA:
undetectable		 5wz2A-4jcnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.83A 5wz2B-4jcnA:
undetectable		 5wz2B-4jcnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 GLY A 248
GLY A 104
GLY A 236
VAL A 131
ILE A 112
 None
 0.85A 5wz2C-4jcnA:
undetectable		 5wz2C-4jcnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 4jcn GLUTAMYL
ENDOPEPTIDASE
(Staphylococcus
epidermidis) 		5 / 12 HIS A 117
ASP A 159
GLY A 233
SER A 235
VAL A 254
 None
 0.89A 6c2mC-4jcnA:
7.9		 6c2mC-4jcnA:
14.16