SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jcp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Brugia
malayi) 		3 / 3 TYR A  55
GLY A  57
PHE A  74
 None
 0.60A 2m2pB-4jcpA:
undetectable		 2m2pB-4jcpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Brugia
malayi) 		4 / 7 PHE A 136
MET A 107
ILE A 121
VAL A 139
 None
 1.02A 3p6hA-4jcpA:
undetectable		 3p6hA-4jcpA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Brugia
malayi) 		4 / 5 VAL A 139
ARG A 138
MET A  22
GLU A  23
 None
SO4  A 203 (-2.9A)
None
None
 1.38A 4hojA-4jcpA:
undetectable		 4hojA-4jcpA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Brugia
malayi) 		4 / 6 LEU A  69
ILE A  12
THR A 159
GLY A 153
 None
 1.04A 4l39A-4jcpA:
undetectable		 4l39A-4jcpA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Brugia
malayi) 		4 / 7 GLY A  72
GLN A 118
SER A  58
HIS A  61
 None
 1.16A 4ws0A-4jcpA:
undetectable		 4ws0A-4jcpA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Brugia
malayi) 		5 / 12 GLY A 116
ILE A  85
ASN A 109
PHE A  36
LEU A 105
 None
 1.05A 5fa8A-4jcpA:
undetectable		 5fa8A-4jcpA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Brugia
malayi) 		4 / 6 PHE A  67
CYH A 122
SER A 106
HIS A 133
 None
 1.43A 5ycnA-4jcpA:
undetectable		 5ycnA-4jcpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Brugia
malayi) 		5 / 9 VAL A 145
SER A 151
GLY A 153
VAL A  63
GLU A 150
 None
 1.28A 5zncA-4jcpA:
undetectable		 5zncA-4jcpA:
19.50