SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jd0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A 152
GLY A 156
VAL A 145
ASP A 166
SER A 190
 None
PO4  A 306 (-3.4A)
None
1KH  A 301 ( 2.6A)
NA  A 312 ( 2.8A)
 1.24A 1nbhC-4jd0A:
undetectable		 1nbhC-4jd0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		4 / 6 LEU A 103
PHE A 101
ALA A   4
LEU A   7
 None
None
None
GOL  A 314 (-4.7A)
 0.91A 1ukbA-4jd0A:
undetectable		 1ukbA-4jd0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		3 / 3 LYS A 141
ASP A  30
ASP A 223
 None
 0.91A 2br4D-4jd0A:
undetectable		 2br4D-4jd0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		5 / 11 LEU A   7
ALA A   4
VAL A  71
GLY A  73
ILE A  74
 GOL  A 314 (-4.7A)
None
None
None
None
 0.79A 3ebzB-4jd0A:
undetectable		 3ebzB-4jd0A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 168
ASP A 166
ILE A 155
GLY A 156
ASN A  85
 1KH  A 301 (-3.4A)
1KH  A 301 ( 2.6A)
None
PO4  A 306 (-3.4A)
GOL  A 314 ( 2.9A)
 0.99A 3eeyJ-4jd0A:
undetectable		 3eeyJ-4jd0A:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		5 / 12 SER A 143
GLY A 129
VAL A 169
GLY A 168
VAL A 145
 1KH  A 301 (-4.6A)
None
None
1KH  A 301 (-3.4A)
None
 1.34A 3f8wB-4jd0A:
undetectable		 3f8wB-4jd0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 169
LEU A 115
VAL A   6
GLY A 106
SER A 108
 None
None
None
GOL  A 314 (-4.2A)
None
 1.06A 3rr3A-4jd0A:
undetectable		 3rr3A-4jd0A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 169
LEU A 115
VAL A   6
GLY A 106
SER A 108
 None
None
None
GOL  A 314 (-4.2A)
None
 1.06A 3rr3B-4jd0A:
undetectable		 3rr3B-4jd0A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 169
LEU A 115
VAL A   6
GLY A 106
SER A 108
 None
None
None
GOL  A 314 (-4.2A)
None
 1.06A 3rr3C-4jd0A:
undetectable		 3rr3C-4jd0A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 169
LEU A 115
VAL A   6
GLY A 106
SER A 108
 None
None
None
GOL  A 314 (-4.2A)
None
 1.06A 3rr3D-4jd0A:
undetectable		 3rr3D-4jd0A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		4 / 5 PHE A 183
PHE A  89
PHE A  90
VAL A 194
 GOL  A 313 (-4.9A)
None
None
None
 1.18A 5a1rA-4jd0A:
undetectable		 5a1rA-4jd0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A   7
ALA A   4
VAL A  71
GLY A  73
ILE A  74
 GOL  A 314 (-4.7A)
None
None
None
None
 0.79A 5e5jA-4jd0A:
undetectable		 5e5jA-4jd0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLY A  12
GLY A  10
SER A   9
ASP A 223
 None
GOL  A 314 (-3.3A)
None
None
 0.82A 5ergB-4jd0A:
2.0		 5ergB-4jd0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4jd0 NUCLEOTIDYL
TRANSFERASE
(Thermotoga
maritima) 		4 / 8 ASP A 219
GLY A 168
LEU A 191
ASN A  85
 NA  A 315 (-3.5A)
1KH  A 301 (-3.4A)
1KH  A 301 (-4.3A)
GOL  A 314 ( 2.9A)
 0.79A 5hwaA-4jd0A:
undetectable		 5hwaA-4jd0A:
22.90