SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4jde PROTEIN F15E11.13
(Caenorhabditis
elegans) 		4 / 5 PHE A  27
GLY A  78
THR A 149
PHE A 148
 None
 1.35A 1icvA-4jdeA:
undetectable
1icvB-4jdeA:
undetectable		 1icvA-4jdeA:
20.56
1icvB-4jdeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4jde PROTEIN F15E11.13
(Caenorhabditis
elegans) 		4 / 5 GLY A  78
ILE A 106
VAL A  31
SER A 107
 None
 1.02A 1rs7A-4jdeA:
undetectable		 1rs7A-4jdeA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4jde PROTEIN F15E11.13
(Caenorhabditis
elegans) 		4 / 6 GLY A  78
ILE A 106
VAL A  31
SER A 107
 None
 0.97A 1rs7B-4jdeA:
undetectable		 1rs7B-4jdeA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4jde PROTEIN F15E11.13
(Caenorhabditis
elegans) 		5 / 12 THR A 125
THR A 126
THR A 127
HIS A 115
LEU A 117
 None
 1.48A 3gwxB-4jdeA:
undetectable		 3gwxB-4jdeA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4jde PROTEIN F15E11.1
(Caenorhabditis
elegans) 		3 / 3 ARG B 119
VAL B   9
THR B  67
 None
None
CL  B 201 (-4.4A)
 0.69A 3k4vD-4jdeB:
undetectable		 3k4vD-4jdeB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4jde PROTEIN F15E11.1
(Caenorhabditis
elegans) 		3 / 3 ARG B 119
VAL B   9
THR B  67
 None
None
CL  B 201 (-4.4A)
 0.80A 3ndtA-4jdeB:
undetectable		 3ndtA-4jdeB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4jde PROTEIN F15E11.1
(Caenorhabditis
elegans) 		5 / 11 THR B 126
ALA B  14
LEU B 118
VAL B  75
ILE B  55
 None
 1.29A 4claA-4jdeB:
undetectable		 4claA-4jdeB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4jde PROTEIN F15E11.13
(Caenorhabditis
elegans) 		4 / 7 ASP A 121
SER A 141
HIS A 115
SER A 139
 None
 1.27A 4k7gB-4jdeA:
undetectable		 4k7gB-4jdeA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4jde PROTEIN F15E11.13
(Caenorhabditis
elegans) 		4 / 6 GLY A  78
ILE A 106
VAL A  31
SER A 107
 None
 1.00A 4kcnA-4jdeA:
undetectable		 4kcnA-4jdeA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4jde PROTEIN F15E11.1
(Caenorhabditis
elegans) 		5 / 12 LEU B  31
GLY B  77
PHE B 138
THR B 146
HIS B 152
 None
 1.18A 5d0yA-4jdeB:
undetectable		 5d0yA-4jdeB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4jde PROTEIN F15E11.13
PROTEIN F15E11.1
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 12 THR A  23
GLY B 100
HIS A 102
MET A  80
PHE A  27
 None
 1.48A 6exiD-4jdeA:
undetectable		 6exiD-4jdeA:
22.92