SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jdy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		3 / 3 GLU A  94
LYS A  86
VAL A  87
 None
GOL  A 301 (-2.8A)
None
 0.94A 1l2iA-4jdyA:
undetectable		 1l2iA-4jdyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 138
PRO A 211
VAL A 212
ILE A 151
 None
 0.88A 2aoiA-4jdyA:
undetectable		 2aoiA-4jdyA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  22
GLY A  25
THR A 260
ILE A 220
 None
 0.90A 2bdmA-4jdyA:
undetectable		 2bdmA-4jdyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 210
PRO A 211
ARG A 143
 None
 0.57A 2qd4B-4jdyA:
2.2		 2qd4B-4jdyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 151
ILE A 220
LEU A 210
MET A 169
 None
 1.13A 3adsA-4jdyA:
undetectable		 3adsA-4jdyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 234
LEU A 232
THR A 216
VAL A 237
 None
 1.00A 3d2tB-4jdyA:
undetectable		 3d2tB-4jdyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 5 ILE A  38
MET A  28
ILE A 243
HIS A 251
 None
 1.20A 3eteB-4jdyA:
undetectable
3eteC-4jdyA:
undetectable		 3eteB-4jdyA:
21.22
3eteC-4jdyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 172
GLY A 138
PRO A 211
VAL A 212
ILE A 151
 None
 1.09A 3oxvB-4jdyA:
undetectable		 3oxvB-4jdyA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 6 THR A 100
GLY A 102
ILE A  76
LEU A  98
 None
 1.02A 4ac9C-4jdyA:
undetectable		 4ac9C-4jdyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 6 THR A 100
GLY A 102
ILE A  76
LEU A  98
 None
 1.02A 4acaC-4jdyA:
undetectable		 4acaC-4jdyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 6 THR A 100
GLY A 102
ILE A  76
LEU A  98
 None
 1.06A 4acbC-4jdyA:
undetectable		 4acbC-4jdyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 8 SER A 153
ALA A 234
LEU A 232
THR A 216
 None
 0.98A 4iklA-4jdyA:
undetectable
4iklB-4jdyA:
undetectable		 4iklA-4jdyA:
20.38
4iklB-4jdyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 6 SER A 109
ARG A 152
GLY A 219
GLY A 158
 None
 0.94A 4koeA-4jdyA:
undetectable
4koeB-4jdyA:
undetectable
4koeC-4jdyA:
undetectable		 4koeA-4jdyA:
20.00
4koeB-4jdyA:
20.00
4koeC-4jdyA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 152
SER A 109
GLY A 219
GLY A 158
 None
 0.93A 4koeA-4jdyA:
undetectable
4koeB-4jdyA:
undetectable
4koeD-4jdyA:
undetectable		 4koeA-4jdyA:
20.00
4koeB-4jdyA:
20.00
4koeD-4jdyA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 256
ILE A 220
ALA A 221
ASP A 225
LEU A 269
 None
 1.47A 4kq8A-4jdyA:
undetectable		 4kq8A-4jdyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 121
LEU A  50
LEU A  98
ILE A  72
PHE A 130
 None
 1.25A 4r38C-4jdyA:
undetectable		 4r38C-4jdyA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 219
GLY A 158
SER A 109
ARG A 152
 None
 0.89A 4z53A-4jdyA:
undetectable
4z53B-4jdyA:
undetectable		 4z53A-4jdyA:
18.42
4z53B-4jdyA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 152
GLY A 219
GLY A 158
SER A 109
 None
 0.91A 4z53A-4jdyA:
undetectable
4z53B-4jdyA:
undetectable		 4z53A-4jdyA:
18.42
4z53B-4jdyA:
18.42