SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4je0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		5 / 12 GLY A 178
GLU A  65
VAL A 168
GLU A 287
ASP A 176
 None
 1.09A 1jdvE-4je0A:
undetectable
1jdvF-4je0A:
undetectable		 1jdvE-4je0A:
20.94
1jdvF-4je0A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		5 / 12 ALA A 171
THR A 284
VAL A 211
GLY A 212
GLN A 293
 None
 1.01A 2ve3A-4je0A:
undetectable		 2ve3A-4je0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		5 / 12 ALA A 171
THR A 284
VAL A 211
GLY A 212
GLN A 293
 None
 1.04A 2ve3B-4je0A:
undetectable		 2ve3B-4je0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		5 / 10 LEU A  31
VAL A  59
ILE A  94
VAL A  57
ILE A 116
 None
 0.95A 3em3B-4je0A:
undetectable		 3em3B-4je0A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		5 / 11 ILE A 160
GLY A 161
LEU A 198
THR A 307
ALA A 295
 None
 1.25A 3kw2B-4je0A:
undetectable		 3kw2B-4je0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		5 / 11 VAL A  43
GLY A  46
ALA A  85
TYR A  96
PHE A  49
 None
 1.42A 3qxyB-4je0A:
undetectable
3qxyQ-4je0A:
undetectable		 3qxyB-4je0A:
19.83
3qxyQ-4je0A:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		5 / 12 LEU A  31
VAL A  59
ILE A  94
VAL A  57
ILE A 116
 None
 0.87A 4dqbA-4je0A:
undetectable		 4dqbA-4je0A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		3 / 3 GLY A  61
GLU A 166
THR A 167
 None
 0.45A 4kouA-4je0A:
undetectable		 4kouA-4je0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		4 / 6 ILE A  51
GLY A 137
ILE A  37
LEU A  33
 None
 0.74A 4o8fB-4je0A:
undetectable		 4o8fB-4je0A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		4 / 8 TYR A 114
ILE A  51
ILE A  94
ALA A  85
 None
 0.90A 4ou1A-4je0A:
undetectable		 4ou1A-4je0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4je0 SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD
(Staphylococcus
aureus) 		4 / 6 TYR A  60
ILE A  67
ALA A  90
ASP A 237
 None
 0.79A 6hu9m-4je0A:
undetectable
6hu9q-4je0A:
undetectable		 6hu9m-4je0A:
20.41
6hu9q-4je0A:
15.87