SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4je3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4je3 CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  27
LEU A  29
VAL A  31
SER A  71
LEU A 103
 None
 1.15A 1db1A-4je3A:
undetectable		 1db1A-4je3A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4je3 CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 101
LEU A  60
LEU A  27
ALA A  21
ILE A  20
 None
 0.99A 2bxcA-4je3A:
undetectable		 2bxcA-4je3A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 413
GLY B 433
ILE B 382
ILE B 409
 None
 0.86A 2q9rA-4je3B:
undetectable		 2q9rA-4je3B:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		5 / 10 GLU A 171
ARG B 396
ILE B 398
LEU B 402
ILE A 165
 None
 1.46A 3adsA-4je3A:
undetectable		 3adsA-4je3A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 4je3 CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  27
LEU A  29
VAL A  31
SER A  71
LEU A 103
 None
 1.14A 3m7rA-4je3A:
undetectable		 3m7rA-4je3A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4je3 CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  29
VAL A  31
ARG A  59
SER A  71
LEU A 103
 None
 1.12A 3vt7A-4je3A:
undetectable		 3vt7A-4je3A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4je3 CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  29
VAL A  31
ARG A  59
SER A  71
VAL A  98
 None
 1.47A 3vt7A-4je3A:
undetectable		 3vt7A-4je3A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 176
LEU A 175
ARG B 396
ILE B 398
 None
 0.85A 4em2A-4je3A:
undetectable		 4em2A-4je3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 165
PRO A 166
GLU A 168
GLN B 448
 None
 0.87A 4g0uB-4je3A:
undetectable		 4g0uB-4je3A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 402
LEU B 416
ILE B 422
LEU B 413
ILE A 192
 None
 1.00A 4odrA-4je3B:
undetectable
4odrB-4je3B:
undetectable		 4odrA-4je3B:
26.13
4odrB-4je3B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 402
LEU B 416
ILE B 422
LEU B 413
ILE A 192
 None
 1.00A 4odrA-4je3B:
undetectable
4odrB-4je3B:
undetectable		 4odrA-4je3B:
26.13
4odrB-4je3B:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4je3 CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  89
VAL A  31
LEU A 100
LEU A   8
PHE A  75
 None
 1.34A 4rtbA-4je3A:
undetectable		 4rtbA-4je3A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4je3 CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 210
LEU A 228
SER A 224
THR A 223
ILE A 221
 None
 1.27A 4ubsA-4je3A:
undetectable		 4ubsA-4je3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 171
ILE B 398
LEU B 402
ILE A 165
 None
 0.95A 4xumA-4je3A:
undetectable		 4xumA-4je3A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		4 / 8 ASN B 405
THR A 153
ILE B 409
GLY B 412
 None
 0.99A 5nzxA-4je3B:
undetectable		 5nzxA-4je3B:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3
(Saccharomyces
cerevisiae) 		4 / 7 ASN B 405
THR A 153
ILE B 409
GLY B 412
 None
 1.01A 5nzyA-4je3B:
undetectable		 5nzyA-4je3B:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
(Saccharomyces
cerevisiae) 		5 / 11 PHE B 447
GLY B 440
VAL B 385
PHE B 410
GLY B 386
 None
 1.21A 5yjsA-4je3B:
undetectable		 5yjsA-4je3B:
23.81