SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4je5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 471
VAL A 476
LEU A 485
LEU A 481
LEU A 488
 None
 1.19A 1mx1B-4je5A:
undetectable		 1mx1B-4je5A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 471
VAL A 476
LEU A 485
LEU A 481
LEU A 488
 None
 1.11A 1mx1C-4je5A:
undetectable		 1mx1C-4je5A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 244
TYR A 235
LEU A 323
TYR A 326
GLY A 318
 None
 1.05A 1pxxC-4je5A:
undetectable		 1pxxC-4je5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 244
TYR A 235
LEU A 323
TYR A 326
GLY A 318
 None
 1.05A 1pxxD-4je5A:
undetectable		 1pxxD-4je5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 327
SER A 328
TYR A 326
LEU A 136
 None
 1.23A 1xz1A-4je5A:
undetectable		 1xz1A-4je5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 327
SER A 328
TYR A 326
LEU A 136
 None
 1.25A 1xz3A-4je5A:
undetectable		 1xz3A-4je5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 181
VAL A 198
TRP A 202
 None
 0.82A 2cc8A-4je5A:
undetectable		 2cc8A-4je5A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 181
VAL A 198
TRP A 202
 None
 0.80A 2ccbA-4je5A:
undetectable		 2ccbA-4je5A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 226
GLY A 223
THR A 222
THR A 217
GLY A 189
 None
 1.46A 2fn1B-4je5A:
undetectable		 2fn1B-4je5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 284
ALA A 285
ARG A 365
THR A 214
PHE A 288
 None
 1.40A 2oaxF-4je5A:
undetectable		 2oaxF-4je5A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 181
VAL A 198
TRP A 202
 None
 0.80A 2vx9A-4je5A:
undetectable		 2vx9A-4je5A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 169
GLU A 162
ASP A 248
 None
None
PLP  A 601 (-2.8A)
 0.70A 2zthA-4je5A:
5.3		 2zthA-4je5A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 TRP A 315
HIS A 277
ASP A 359
GLN A 354
ILE A 124
 None
EPE  A 602 (-3.7A)
EPE  A 602 ( 4.6A)
None
None
 1.22A 3b7pB-4je5A:
4.7		 3b7pB-4je5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 169
GLU A 162
ASP A 248
 None
None
PLP  A 601 (-2.8A)
 0.87A 3bwmA-4je5A:
4.9		 3bwmA-4je5A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 169
GLU A 162
ASP A 248
 None
None
PLP  A 601 (-2.8A)
 0.81A 3bwyA-4je5A:
4.9		 3bwyA-4je5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 360
TRP A 352
THR A 348
 None
 1.46A 4bboB-4je5A:
undetectable		 4bboB-4je5A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 344
VAL A  57
LEU A 103
LEU A  99
 None
 0.99A 4l1xA-4je5A:
undetectable		 4l1xA-4je5A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 449
ILE A 179
PHE A 181
VAL A 158
 None
 1.49A 4tvtA-4je5A:
undetectable		 4tvtA-4je5A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 312
GLY A 140
ALA A 139
GLY A 314
 PLP  A 601 (-3.0A)
PLP  A 601 (-3.4A)
None
None
 0.92A 4u9uA-4je5A:
undetectable		 4u9uA-4je5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 312
GLY A 140
ALA A 139
GLY A 314
 PLP  A 601 (-3.0A)
PLP  A 601 (-3.4A)
None
None
 0.94A 4u9uB-4je5A:
undetectable		 4u9uB-4je5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 137
GLN A 354
LEU A 114
ASN A 116
ARG A 119
 None
 1.48A 4x30A-4je5A:
undetectable		 4x30A-4je5A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 169
GLU A 162
ASP A 248
 None
None
PLP  A 601 (-2.8A)
 0.84A 4xudA-4je5A:
4.8		 4xudA-4je5A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 7 THR A 348
LEU A 349
THR A 341
THR A 311
LEU A 313
 None
 1.19A 4z91F-4je5A:
undetectable
4z91G-4je5A:
undetectable
4z91H-4je5A:
undetectable
4z91I-4je5A:
undetectable
4z91J-4je5A:
undetectable		 4z91F-4je5A:
20.50
4z91G-4je5A:
20.50
4z91H-4je5A:
20.50
4z91I-4je5A:
20.50
4z91J-4je5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 146
THR A 148
HIS A 164
LEU A 170
 None
None
None
EPE  A 603 ( 4.0A)
 1.23A 5axaA-4je5A:
2.4		 5axaA-4je5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 146
THR A 148
HIS A 164
LEU A 170
 None
None
None
EPE  A 603 ( 4.0A)
 1.22A 5axaC-4je5A:
2.4		 5axaC-4je5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 286
SER A 290
ARG A 299
 None
 0.95A 5b2qA-4je5A:
undetectable		 5b2qA-4je5A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 SER A 147
ARG A 299
GLY A 318
THR A 122
 None
 1.09A 5btiA-4je5A:
4.1
5btiB-4je5A:
undetectable		 5btiA-4je5A:
23.94
5btiB-4je5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 SER A 147
ARG A 299
GLY A 318
THR A 122
 None
 1.19A 5btiC-4je5A:
4.0
5btiD-4je5A:
undetectable		 5btiC-4je5A:
23.94
5btiD-4je5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 145
ILE A 215
SER A 165
 None
PLP  A 601 (-3.9A)
None
 1.02A 5gqbA-4je5A:
2.5		 5gqbA-4je5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 TRP A 315
ASP A 301
ARG A 299
LEU A 284
HIS A 121
 None
 1.35A 5nn8A-4je5A:
undetectable		 5nn8A-4je5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 423
ALA A 388
SER A 386
PRO A 384
GLY A 489
 None
 1.26A 5syeB-4je5A:
2.9		 5syeB-4je5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 THR A 148
VAL A 151
HIS A 330
ILE A 334
 None
 1.20A 5vkqA-4je5A:
undetectable
5vkqB-4je5A:
undetectable		 5vkqA-4je5A:
14.20
5vkqB-4je5A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 THR A 148
VAL A 151
HIS A 330
ILE A 334
 None
 1.19A 5vkqC-4je5A:
undetectable
5vkqD-4je5A:
undetectable		 5vkqC-4je5A:
14.20
5vkqD-4je5A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ASN A  92
ASP A  96
SER A  94
ARG A 351
 None
 1.40A 5w4zA-4je5A:
undetectable		 5w4zA-4je5A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 231
ASN A 286
SER A 290
 None
 0.83A 5yw0A-4je5A:
undetectable		 5yw0A-4je5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 4 PHE A 152
ASP A 157
LEU A 244
LYS A 210
 None
 1.36A 6awvA-4je5A:
undetectable		 6awvA-4je5A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 416
ASP A 419
GLN A 422
 None
 0.80A 6g1pA-4je5A:
undetectable		 6g1pA-4je5A:
21.21