SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jed'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4jed GLUTATHIONE
S-TRANSFERASE
(Methylobacterium
radiotolerans) 		3 / 3 ARG A 116
ARG A 174
PRO A 176
 None
None
GOL  A 301 (-4.5A)
 1.06A 2wljA-4jedA:
undetectable		 2wljA-4jedA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4jed GLUTATHIONE
S-TRANSFERASE
(Methylobacterium
radiotolerans) 		5 / 8 PHE A 157
ALA A  95
PHE A 200
ALA A 163
THR A 166
 None
 1.35A 3t3sF-4jedA:
1.7		 3t3sF-4jedA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4jed GLUTATHIONE
S-TRANSFERASE
(Methylobacterium
radiotolerans) 		5 / 12 SER A 191
LEU A 194
ILE A 105
ILE A 142
LEU A 146
 None
 1.11A 3w67B-4jedA:
undetectable		 3w67B-4jedA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4jed GLUTATHIONE
S-TRANSFERASE
(Methylobacterium
radiotolerans) 		4 / 7 SER A  14
VAL A 110
ARG A 174
TYR A 170
 GTS  A 302 (-2.5A)
None
None
None
 0.93A 4ijiH-4jedA:
23.2		 4ijiH-4jedA:
33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4jed GLUTATHIONE
S-TRANSFERASE
(Methylobacterium
radiotolerans) 		4 / 4 GLU A 136
GLY A 137
HIS A 184
ARG A 183
 None
 1.50A 4r82A-4jedA:
undetectable
4r82B-4jedA:
undetectable		 4r82A-4jedA:
25.45
4r82B-4jedA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4jed GLUTATHIONE
S-TRANSFERASE
(Methylobacterium
radiotolerans) 		4 / 8 ARG A 156
PRO A  87
GLY A  91
ASP A  88
 None
 1.13A 5kf8A-4jedA:
undetectable		 5kf8A-4jedA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4jed GLUTATHIONE
S-TRANSFERASE
(Methylobacterium
radiotolerans) 		4 / 8 ARG A 156
PRO A  87
GLY A  91
ASP A  88
 None
 1.07A 5kgpA-4jedA:
undetectable		 5kgpA-4jedA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4jed GLUTATHIONE
S-TRANSFERASE
(Methylobacterium
radiotolerans) 		4 / 8 ARG A 156
PRO A  87
GLY A  91
ASP A  88
 None
 1.05A 5kgpB-4jedA:
undetectable		 5kgpB-4jedA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jed GLUTATHIONE
S-TRANSFERASE
(Methylobacterium
radiotolerans) 		4 / 4 GLN A 131
THR A 112
GLU A 177
LEU A 139
 None
 1.30A 5m66A-4jedA:
undetectable		 5m66A-4jedA:
19.17