SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jej'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 9 LEU A 191
ILE A 194
VAL A 228
GLY A 208
ALA A 225
 None
None
None
1GP  A 301 (-3.4A)
None
 1.03A 1e7aA-4jejA:
undetectable		 1e7aA-4jejA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 6 LEU A 102
GLU A 180
THR A 143
ALA A 146
 PGE  A 302 ( 3.7A)
1GP  A 301 (-2.1A)
None
None
 1.27A 1etb2-4jejA:
undetectable		 1etb2-4jejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 9 LEU A 176
LYS A 175
ILE A 130
VAL A  81
PHE A  54
 None
 1.37A 1gx8A-4jejA:
undetectable		 1gx8A-4jejA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 6 ILE A 211
LYS A 219
ALA A 223
VAL A 228
 MG  A 304 ( 3.7A)
None
None
None
 0.96A 1hk1A-4jejA:
undetectable		 1hk1A-4jejA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 4 LEU A 103
PRO A  87
ILE A 112
LEU A 111
 None
PGE  A 302 ( 3.2A)
None
None
 1.02A 1ya4B-4jejA:
undetectable		 1ya4B-4jejA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 4 LEU A 103
PRO A  87
ILE A 112
LEU A 111
 None
PGE  A 302 ( 3.2A)
None
None
 0.96A 1ya4C-4jejA:
undetectable		 1ya4C-4jejA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 12 LEU A 100
ILE A  13
SER A 104
VAL A 145
VAL A 229
 PGE  A 302 (-3.7A)
None
None
PGE  A 302 ( 4.7A)
1GP  A 301 (-4.1A)
 1.08A 2po7A-4jejA:
3.0		 2po7A-4jejA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 12 LEU A  38
LEU A  72
VAL A  80
ILE A  26
PHE A 234
 None
 1.27A 2weyA-4jejA:
undetectable		 2weyA-4jejA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 10 GLY A 224
ALA A 223
ILE A 217
PRO A 188
VAL A 189
 None
 0.97A 3ekyA-4jejA:
undetectable		 3ekyA-4jejA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 12 ASP A  39
LEU A  38
ILE A  53
LEU A  28
LEU A  68
 None
 1.16A 3k2hA-4jejA:
undetectable		 3k2hA-4jejA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 8 ILE A 177
SER A 101
SER A 131
GLY A 133
 None
 0.97A 3lslA-4jejA:
undetectable
3lslD-4jejA:
undetectable		 3lslA-4jejA:
23.33
3lslD-4jejA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 8 ILE A 177
SER A 101
SER A 131
GLY A 133
 None
 0.87A 3lslA-4jejA:
undetectable
3lslD-4jejA:
undetectable		 3lslA-4jejA:
23.33
3lslD-4jejA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 12 ALA A  96
LEU A  98
ILE A  13
LYS A 175
ILE A 206
 None
 1.13A 3ut5B-4jejA:
undetectable		 3ut5B-4jejA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 8 GLY A 208
VAL A 207
ILE A 217
PHE A 240
 1GP  A 301 (-3.4A)
None
None
None
 0.86A 4fglD-4jejA:
undetectable		 4fglD-4jejA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 7 GLY A 208
VAL A 207
ILE A 217
PHE A 240
 1GP  A 301 (-3.4A)
None
None
None
 0.82A 4fglC-4jejA:
undetectable		 4fglC-4jejA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 5 PRO A  30
ASP A  29
ILE A  59
VAL A 145
 None
None
None
PGE  A 302 ( 4.7A)
 1.28A 4hytA-4jejA:
undetectable		 4hytA-4jejA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		3 / 3 LYS A 219
LEU A 191
ALA A 220
 None
 0.69A 4iizA-4jejA:
undetectable		 4iizA-4jejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		5 / 12 ALA A  96
LEU A  98
ILE A  13
LYS A 175
ILE A 206
 None
 1.12A 5itzB-4jejA:
undetectable		 5itzB-4jejA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE
(Flavobacterium
johnsoniae) 		4 / 8 LEU A 102
TYR A 134
GLU A 180
THR A 151
 PGE  A 302 ( 3.7A)
PGE  A 302 ( 4.0A)
1GP  A 301 (-2.1A)
PO4  A 303 (-4.0A)
 1.13A 6c71B-4jejA:
undetectable		 6c71B-4jejA:
17.21