SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4jem CMP/HYDROXYMETHYL
CMP HYDROLASE
(Streptomyces
rimofaciens) 		4 / 8 VAL A 115
VAL A 156
LEU A 140
HIS A  47
 None
 1.04A 2ddwA-4jemA:
3.3		 2ddwA-4jemA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4jem CMP/HYDROXYMETHYL
CMP HYDROLASE
(Streptomyces
rimofaciens) 		3 / 3 VAL A 137
GLU A 132
GLU A 138
 None
 0.79A 2nv4A-4jemA:
undetectable		 2nv4A-4jemA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 4jem CMP/HYDROXYMETHYL
CMP HYDROLASE
(Streptomyces
rimofaciens) 		5 / 12 ILE A 104
GLY A 111
GLY A 109
ALA A 135
ALA A 163
 None
 1.06A 4kicB-4jemA:
2.9		 4kicB-4jemA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4jem CMP/HYDROXYMETHYL
CMP HYDROLASE
(Streptomyces
rimofaciens) 		5 / 9 ALA A  12
VAL A 156
ALA A 157
VAL A  87
GLY A 161
 None
 1.19A 6bklA-4jemA:
undetectable
6bklB-4jemA:
undetectable
6bklC-4jemA:
undetectable
6bklD-4jemA:
undetectable		 6bklA-4jemA:
10.97
6bklB-4jemA:
10.97
6bklC-4jemA:
10.97
6bklD-4jemA:
10.97