SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 ILE A   5
PHE A 116
LEU A  20
ILE A 114
TYR A 178
 None
 0.96A 1cd2A-4jerA:
undetectable		 1cd2A-4jerA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 ILE A   5
PHE A 116
LEU A  20
ILE A 114
TYR A 178
 None
 0.95A 1drbB-4jerA:
undetectable		 1drbB-4jerA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		4 / 8 PHE A  92
LEU A 146
LEU A 121
LEU A 119
 None
 0.97A 2bfpA-4jerA:
undetectable		 2bfpA-4jerA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		4 / 4 ALA A  12
TYR A  11
ALA A 168
TYR A  14
 None
 1.24A 2wlkA-4jerA:
undetectable
2wlkB-4jerA:
undetectable		 2wlkA-4jerA:
18.48
2wlkB-4jerA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 GLU A  22
ALA A  69
LEU A 119
ILE A 114
MET A 158
 None
 1.34A 2xkwB-4jerA:
undetectable		 2xkwB-4jerA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 ALA A  69
ILE A  87
LEU A 119
ILE A 114
MET A 158
 None
 0.97A 3adsB-4jerA:
undetectable		 3adsB-4jerA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 ALA A  69
ILE A  87
LEU A 119
ILE A 114
MET A 158
 None
 0.89A 3adxB-4jerA:
undetectable		 3adxB-4jerA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		3 / 3 LEU A  20
TRP A  23
GLY A  66
 None
 0.80A 3l35A-4jerA:
undetectable
3l35H-4jerA:
undetectable		 3l35A-4jerA:
14.29
3l35H-4jerA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		3 / 3 LEU A  20
TRP A  23
GLY A  66
 None
 0.79A 3l35B-4jerA:
undetectable
3l35K-4jerA:
undetectable		 3l35B-4jerA:
14.29
3l35K-4jerA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		3 / 3 LYS A 148
ASN A  63
ASP A  31
 None
 0.77A 4o1eA-4jerA:
undetectable		 4o1eA-4jerA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		3 / 3 GLU A  65
LYS A  94
ASN A  63
 None
 1.02A 4y1dA-4jerA:
undetectable
4y1dD-4jerA:
undetectable		 4y1dA-4jerA:
21.26
4y1dD-4jerA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 10 TYR A  19
MET A 154
LEU A 146
LEU A  90
GLY A  58
 None
 1.06A 4zp0A-4jerA:
undetectable		 4zp0A-4jerA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 GLY A 149
LEU A 109
GLY A  58
SER A  60
ILE A  57
 None
 0.87A 5vooA-4jerA:
undetectable		 5vooA-4jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 GLY A 149
LEU A 109
GLY A  58
SER A  60
ILE A  57
 None
 0.89A 5vooB-4jerA:
undetectable		 5vooB-4jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 GLY A 149
LEU A 109
GLY A  58
SER A  60
ILE A  57
 None
 0.88A 5vooC-4jerA:
undetectable		 5vooC-4jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 GLY A 149
LEU A 109
GLY A  58
SER A  60
ILE A  57
 None
 0.90A 5vooD-4jerA:
undetectable		 5vooD-4jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 GLY A 149
LEU A 109
GLY A  58
SER A  60
ILE A  57
 None
 0.95A 5vooE-4jerA:
undetectable		 5vooE-4jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 GLY A 149
LEU A 109
GLY A  58
SER A  60
ILE A  57
 None
 0.95A 5vooF-4jerA:
undetectable		 5vooF-4jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 GLY A 149
LEU A 109
GLY A  58
SER A  60
ILE A  57
 None
 0.88A 5vopA-4jerA:
undetectable		 5vopA-4jerA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jer HEMOPHORE HASA
(Yersinia
pestis) 		5 / 12 GLY A 149
LEU A 109
GLY A  58
SER A  60
ILE A  57
 None
 1.00A 5vopB-4jerA:
undetectable		 5vopB-4jerA:
20.74