SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 ALA A 110
PHE A  60
ALA A 108
ILE A  94
LEU A  87
 None
 0.98A 1fm6U-4jfcA:
undetectable		 1fm6U-4jfcA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		4 / 8 LEU A  69
VAL A 138
TYR A 135
GLY A 139
 GOL  A 301 ( 4.5A)
None
None
None
 0.93A 1jlbA-4jfcA:
undetectable		 1jlbA-4jfcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		4 / 7 LEU A  69
VAL A 138
TYR A 135
GLY A 139
 GOL  A 301 ( 4.5A)
None
None
None
 0.94A 1lweA-4jfcA:
undetectable		 1lweA-4jfcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		4 / 8 LEU A  69
VAL A 138
TYR A 135
GLY A 139
 GOL  A 301 ( 4.5A)
None
None
None
 1.03A 1s1xA-4jfcA:
undetectable		 1s1xA-4jfcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		4 / 8 LEU A 223
LEU A 227
ALA A 218
LEU A 214
 None
 0.76A 2vcvP-4jfcA:
undetectable		 2vcvP-4jfcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 10 TRP A  90
PHE A  60
ALA A 112
LEU A 116
ALA A 117
 None
None
GOL  A 301 (-3.4A)
None
None
 1.44A 2wscB-4jfcA:
undetectable		 2wscB-4jfcA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 10 TRP A  90
PHE A  60
ALA A 112
LEU A 116
ALA A 117
 None
None
GOL  A 301 (-3.4A)
None
None
 1.45A 2wseB-4jfcA:
undetectable		 2wseB-4jfcA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 10 ILE A  91
GLY A 146
PHE A 114
VAL A 123
LEU A  27
 None
 1.34A 3elzB-4jfcA:
undetectable		 3elzB-4jfcA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 ALA A 110
PHE A  60
ALA A 108
ILE A  94
LEU A  87
 None
 0.94A 3oapA-4jfcA:
undetectable		 3oapA-4jfcA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 HIS A  88
GLY A  86
ALA A  26
GLY A  63
ASN A  20
 None
 1.26A 3v3oB-4jfcA:
undetectable		 3v3oB-4jfcA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 LEU A  87
PHE A  60
LEU A  16
ALA A  34
ALA A  38
 None
 1.09A 3vw7A-4jfcA:
undetectable		 3vw7A-4jfcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 GLY A 146
GLY A 144
LEU A  87
ALA A 151
LEU A 163
 None
 1.22A 3vywB-4jfcA:
undetectable		 3vywB-4jfcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 GLY A 146
GLY A 144
LEU A  87
ALA A 151
LEU A 163
 None
 1.21A 3vywD-4jfcA:
undetectable		 3vywD-4jfcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		4 / 7 ALA A 125
PHE A 131
ALA A 109
ALA A 103
 None
 0.77A 4du2A-4jfcA:
undetectable		 4du2A-4jfcA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		4 / 7 ALA A 125
PHE A 131
ALA A 109
ALA A 103
 None
 0.70A 4du2B-4jfcA:
undetectable		 4du2B-4jfcA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 10 ALA A 112
LEU A  27
GLY A  28
ALA A 193
MET A 196
 GOL  A 301 (-3.4A)
None
None
None
None
 1.49A 4fe1A-4jfcA:
undetectable
4fe1J-4jfcA:
undetectable		 4fe1A-4jfcA:
16.62
4fe1J-4jfcA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 ILE A  31
LEU A  16
SER A  93
ILE A  94
LEU A 116
 None
 1.06A 4gh8A-4jfcA:
undetectable		 4gh8A-4jfcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 ALA A 109
LEU A  27
ILE A  91
LEU A  87
LEU A 118
 None
 1.09A 4j24D-4jfcA:
undetectable		 4j24D-4jfcA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 11 ALA A 109
LEU A  27
ILE A  91
GLY A 145
LEU A 118
 None
 1.09A 5dxbB-4jfcA:
undetectable		 5dxbB-4jfcA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 ALA A 109
LEU A  27
ILE A  91
GLY A 145
LEU A 118
 None
 1.10A 5gs4A-4jfcA:
undetectable		 5gs4A-4jfcA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		6 / 12 ILE A  31
ALA A  34
LEU A  16
SER A  93
ILE A  94
LEU A 116
 None
 1.22A 5hi6B-4jfcA:
undetectable		 5hi6B-4jfcA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 GLU A  30
GLY A   3
GLU A  22
ARG A  24
ALA A  26
 None
 1.18A 5n5dA-4jfcA:
undetectable		 5n5dA-4jfcA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4jfc ENOYL-COA HYDRATASE
(Polaromonas
sp.
JS666) 		5 / 12 LEU A  18
VAL A 105
VAL A 101
TYR A  97
SER A  93
 None
 1.07A 5v1tA-4jfcA:
2.9		 5v1tA-4jfcA:
22.25