SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jga'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 SER A 161
GLY A 158
LEU A 155
ASN A 154
MET A  83
 None
 1.26A 1a27A-4jgaA:
undetectable		 1a27A-4jgaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 202
ILE A 366
ALA A  93
GLY A  90
ALA A  94
 None
 0.92A 1bx4A-4jgaA:
undetectable		 1bx4A-4jgaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		4 / 6 LEU A 421
ARG A 373
TYR A 314
VAL A 253
 None
 1.14A 1db1A-4jgaA:
undetectable		 1db1A-4jgaA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 270
LEU A  15
VAL A 253
LEU A 255
PHE A 365
 None
 0.87A 1gseB-4jgaA:
undetectable		 1gseB-4jgaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		4 / 6 ILE A 404
LYS A 401
LYS A 400
ALA A 399
 None
 1.23A 1hk2A-4jgaA:
undetectable		 1hk2A-4jgaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.88A 1hxbA-4jgaA:
undetectable		 1hxbA-4jgaA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 ILE A 184
GLY A 202
ILE A 200
SER A 120
ALA A 250
 None
 0.91A 1sg9B-4jgaA:
undetectable		 1sg9B-4jgaA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		6 / 12 ILE A 366
GLY A 251
GLY A 203
ILE A 184
VAL A  18
ALA A  94
 None
 1.31A 1sg9B-4jgaA:
undetectable		 1sg9B-4jgaA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 203
ALA A 183
ILE A 184
VAL A  18
ALA A  94
 None
 1.15A 1vq1A-4jgaA:
undetectable		 1vq1A-4jgaA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 ILE A 191
LEU A 255
ALA A 196
GLY A 115
LEU A 118
 None
 1.11A 2a58A-4jgaA:
undetectable
2a58B-4jgaA:
undetectable		 2a58A-4jgaA:
17.87
2a58B-4jgaA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 ILE A 191
LEU A 255
ALA A 196
GLY A 115
LEU A 118
 None
 1.12A 2a58B-4jgaA:
undetectable
2a58C-4jgaA:
undetectable		 2a58B-4jgaA:
17.87
2a58C-4jgaA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 ILE A 191
LEU A 255
ALA A 196
GLY A 115
LEU A 118
 None
 1.11A 2a58D-4jgaA:
undetectable
2a58E-4jgaA:
undetectable		 2a58D-4jgaA:
17.87
2a58E-4jgaA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 202
GLY A 180
HIS A 182
ALA A 250
ALA A  94
 None
 0.84A 2gluA-4jgaA:
undetectable		 2gluA-4jgaA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 202
GLY A 180
HIS A 182
ALA A 250
ALA A  94
 None
 0.80A 2gluB-4jgaA:
undetectable		 2gluB-4jgaA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.92A 2hs1A-4jgaA:
undetectable		 2hs1A-4jgaA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.89A 2nmyA-4jgaA:
undetectable		 2nmyA-4jgaA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.91A 2nnkA-4jgaA:
undetectable		 2nnkA-4jgaA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 11 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.93A 2nnpA-4jgaA:
undetectable		 2nnpA-4jgaA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.90A 2q5kB-4jgaA:
undetectable		 2q5kB-4jgaA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 10 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.93A 2r5qD-4jgaA:
undetectable		 2r5qD-4jgaA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 PRO A 207
ALA A 206
ALA A 218
THR A 224
MET A 246
 None
 1.10A 2x2nA-4jgaA:
undetectable		 2x2nA-4jgaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 PRO A 207
ALA A 206
ALA A 218
THR A 224
MET A 246
 None
 1.05A 2x2nB-4jgaA:
undetectable		 2x2nB-4jgaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		3 / 3 MET A 127
VAL A 213
GLU A 248
 None
 0.80A 2x9gA-4jgaA:
undetectable		 2x9gA-4jgaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 10 VAL A  21
ILE A 353
LEU A 356
GLY A 251
ALA A  93
 None
 1.24A 2xf3A-4jgaA:
undetectable		 2xf3A-4jgaA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 ALA A 250
PHE A 216
SER A 120
GLY A 121
THR A 179
 None
 1.27A 2xffA-4jgaA:
undetectable		 2xffA-4jgaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		4 / 7 THR A 209
GLY A 212
PHE A 216
ILE A 122
 None
None
None
EDO  A 502 (-4.9A)
 0.80A 2y7wC-4jgaA:
1.0		 2y7wC-4jgaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		4 / 4 GLY A 180
GLY A 203
GLY A 119
GLY A 202
 None
 0.60A 3bogD-4jgaA:
undetectable		 3bogD-4jgaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 10 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.97A 3el9B-4jgaA:
undetectable		 3el9B-4jgaA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		4 / 7 LEU A 408
ARG A 299
SER A 178
GLY A 293
 None
 1.07A 3hcnA-4jgaA:
undetectable		 3hcnA-4jgaA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		4 / 7 LEU A 408
ARG A 299
SER A 178
GLY A 293
 None
 1.09A 3hcrB-4jgaA:
2.2		 3hcrB-4jgaA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 ILE A 184
GLY A 202
ALA A 250
PHE A 365
ILE A 117
 None
 1.03A 3jayA-4jgaA:
undetectable		 3jayA-4jgaA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		3 / 3 SER A 348
GLY A 319
SER A 234
 None
 0.57A 3loqA-4jgaA:
undetectable		 3loqA-4jgaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 202
GLY A 180
VAL A 363
ALA A  93
ALA A  94
 None
 1.20A 3mteA-4jgaA:
undetectable		 3mteA-4jgaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 202
GLY A 180
ALA A  93
ALA A  94
LEU A 118
 None
 0.97A 3p2kA-4jgaA:
undetectable		 3p2kA-4jgaA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 ALA A 221
PHE A 244
ILE A 122
LEU A 357
GLY A 215
 None
None
EDO  A 502 (-4.9A)
None
None
 0.87A 3rukB-4jgaA:
undetectable		 3rukB-4jgaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A  65
LEU A  17
GLY A  22
ALA A  92
ALA A  93
 None
 0.96A 3sufA-4jgaA:
undetectable		 3sufA-4jgaA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 LEU A 336
ILE A 307
ILE A 312
ASP A 304
ALA A 301
 None
 1.02A 3uj7A-4jgaA:
undetectable		 3uj7A-4jgaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 LEU A 336
ILE A 307
ILE A 312
ASP A 304
ALA A 301
 None
 1.03A 3uj7B-4jgaA:
undetectable		 3uj7B-4jgaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 ILE A 366
THR A 349
SER A 352
ILE A 353
LEU A 356
 None
 1.06A 4dfrA-4jgaA:
undetectable		 4dfrA-4jgaA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 11 GLY A 203
ALA A 360
LEU A 357
GLY A 121
ALA A  51
 None
 1.23A 4l6v1-4jgaA:
undetectable
4l6v6-4jgaA:
undetectable		 4l6v1-4jgaA:
20.65
4l6v6-4jgaA:
12.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		7 / 12 ALA A 176
CYH A 177
GLU A 205
PHE A 244
LEU A 357
GLY A 413
PHE A 414
 None
 1.50A 4ls7A-4jgaA:
67.2		 4ls7A-4jgaA:
50.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		11 / 12 GLY A 121
ALA A 176
CYH A 177
GLU A 205
PHE A 216
HIS A 318
THR A 320
HIS A 355
LEU A 357
GLY A 413
PHE A 414
 None
 0.29A 4ls7A-4jgaA:
67.2		 4ls7A-4jgaA:
50.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		9 / 12 ALA A 176
CYH A 177
PHE A 216
HIS A 318
THR A 320
HIS A 355
LEU A 357
GLY A 413
PHE A 414
 None
 0.31A 4ls7A-4jgaA:
67.2
4ls7B-4jgaA:
67.0		 4ls7A-4jgaA:
50.57
4ls7B-4jgaA:
50.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		7 / 12 ILE A 122
ALA A 176
CYH A 177
HIS A 318
THR A 320
HIS A 355
GLY A 413
 EDO  A 502 (-4.9A)
None
None
None
None
None
None
 0.60A 4ls7A-4jgaA:
67.2
4ls7B-4jgaA:
67.0		 4ls7A-4jgaA:
50.57
4ls7B-4jgaA:
50.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 11 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.99A 4qgiA-4jgaA:
undetectable		 4qgiA-4jgaA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 10 TYR A 275
LEU A 421
ALA A 250
ALA A 201
GLY A 361
 None
 1.35A 4rn6A-4jgaA:
undetectable		 4rn6A-4jgaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 11 THR A 175
SER A 411
ALA A 301
GLU A 364
GLY A 202
 None
K  A 501 ( 4.6A)
None
K  A 501 (-3.6A)
None
 1.08A 4zjoD-4jgaA:
undetectable		 4zjoD-4jgaA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		4 / 5 THR A 278
GLY A 293
GLU A 329
HIS A 318
 None
 1.21A 5c0oH-4jgaA:
undetectable		 5c0oH-4jgaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		6 / 12 SER A 362
GLY A 361
GLY A 121
GLY A 119
GLY A 180
ILE A 122
 None
None
None
None
None
EDO  A 502 (-4.9A)
 1.35A 5ec8A-4jgaA:
undetectable		 5ec8A-4jgaA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 11 PHE A 244
ILE A 353
VAL A 208
VAL A 213
LEU A 357
 None
 1.15A 5jkwA-4jgaA:
undetectable		 5jkwA-4jgaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		4 / 5 TYR A 275
SER A 420
ALA A 419
THR A 417
 None
 1.28A 5n0tA-4jgaA:
undetectable		 5n0tA-4jgaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		4 / 5 TYR A 275
SER A 420
ALA A 419
THR A 417
 None
 1.39A 5n0wB-4jgaA:
undetectable		 5n0wB-4jgaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 416
PRO A 287
ALA A 286
ASP A 280
THR A 417
 None
 1.14A 5x6yC-4jgaA:
undetectable		 5x6yC-4jgaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.94A 6dj1B-4jgaA:
undetectable		 6dj1B-4jgaA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 GLY A 276
ALA A 301
ASP A 304
ILE A 273
ILE A 184
 None
 0.94A 6dj2B-4jgaA:
undetectable		 6dj2B-4jgaA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		3 / 3 SER A 351
SER A 352
ALA A 399
 None
 0.68A 6dwnC-4jgaA:
undetectable		 6dwnC-4jgaA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Rickettsia
rickettsii) 		5 / 12 ILE A 184
GLY A 276
ALA A 301
ASP A 304
ILE A 423
 None
 1.09A 6dwnD-4jgaA:
undetectable		 6dwnD-4jgaA:
11.45