SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jgf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4jgf GAMMA-CRYSTALLIN D
(Homo
sapiens) 		4 / 8 TYR A   6
PHE A  11
GLY A   1
SER A  19
 None
 0.64A 3ihzB-4jgfA:
undetectable		 3ihzB-4jgfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4jgf GAMMA-CRYSTALLIN D
(Homo
sapiens) 		5 / 9 TYR A 150
VAL A 125
GLY A 148
VAL A 131
GLN A 142
 None
 1.34A 3kmoA-4jgfA:
undetectable		 3kmoA-4jgfA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4jgf GAMMA-CRYSTALLIN D
(Homo
sapiens) 		4 / 8 VAL A  75
LEU A  25
LEU A  29
ILE A   3
 None
 0.88A 3u5kA-4jgfA:
undetectable		 3u5kA-4jgfA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4jgf GAMMA-CRYSTALLIN D
(Homo
sapiens) 		4 / 8 VAL A  75
LEU A  25
LEU A  29
ILE A   3
 None
 0.91A 3u5kC-4jgfA:
undetectable		 3u5kC-4jgfA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4jgf GAMMA-CRYSTALLIN D
(Homo
sapiens) 		5 / 12 GLN A 142
GLY A  70
LEU A  53
CYH A  32
ASP A  73
 None
 1.37A 5vlmF-4jgfA:
undetectable		 5vlmF-4jgfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jgf GAMMA-CRYSTALLIN D
(Homo
sapiens) 		3 / 3 SER A  20
HIS A  22
TYR A  16
 None
 0.93A 5y2tA-4jgfA:
undetectable		 5y2tA-4jgfA:
undetectable