SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  90
LEU A  86
LEU A 111
GLY A  73
 None
 1.06A 1a4lC-4jggA:
2.6		 1a4lC-4jggA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.27A 1fk9A-4jggA:
undetectable		 1fk9A-4jggA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.28A 1fkpA-4jggA:
undetectable		 1fkpA-4jggA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.35A 1ikvA-4jggA:
undetectable		 1ikvA-4jggA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.35A 1ikwA-4jggA:
undetectable		 1ikwA-4jggA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 9 GLY A  52
GLY A   7
GLY A  73
GLY A  74
ASP A  76
 None
 1.00A 1mxdA-4jggA:
undetectable		 1mxdA-4jggA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  52
GLY A   7
GLY A  73
GLY A  74
ASP A  76
 None
 0.99A 1mxgA-4jggA:
2.2		 1mxgA-4jggA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  86
LEU A 138
VAL A 130
GLY A 128
ALA A 129
 None
 0.97A 1pxxA-4jggA:
undetectable		 1pxxA-4jggA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  86
LEU A 138
VAL A 130
GLY A 128
ALA A 129
 None
 0.98A 1pxxC-4jggA:
undetectable		 1pxxC-4jggA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  86
LEU A 138
VAL A 130
GLY A 128
ALA A 129
 None
 0.99A 1pxxD-4jggA:
undetectable		 1pxxD-4jggA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 176
VAL A  39
TYR A  35
LEU A  67
 None
 1.02A 1s1xA-4jggA:
undetectable		 1s1xA-4jggA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 176
TYR A  35
TYR A  37
PRO A  65
LEU A  67
 None
 1.17A 1sv5A-4jggA:
undetectable		 1sv5A-4jggA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 107
ILE A 109
VAL A 146
GLY A 147
LEU A 168
 None
 1.41A 2bxeA-4jggA:
undetectable		 2bxeA-4jggA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.29A 2hndA-4jggA:
undetectable		 2hndA-4jggA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.30A 2hnyA-4jggA:
undetectable		 2hnyA-4jggA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 109
ASP A   8
ILE A  10
PHE A 142
 None
 0.82A 2w9sE-4jggA:
undetectable		 2w9sE-4jggA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.33A 3hvtA-4jggA:
0.9		 3hvtA-4jggA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.30A 3qipA-4jggA:
undetectable		 3qipA-4jggA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.22A 4b3oA-4jggA:
1.5		 4b3oA-4jggA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		4 / 7 VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 0.95A 4b3qA-4jggA:
undetectable		 4b3qA-4jggA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  69
LEU A   3
VAL A   5
LEU A  26
VAL A  39
 None
 0.94A 4e3hA-4jggA:
undetectable		 4e3hA-4jggA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 105
VAL A  69
LEU A   3
VAL A   5
LEU A  26
 None
 0.96A 4m2wA-4jggA:
undetectable		 4m2wA-4jggA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.30A 4puoA-4jggA:
1.4		 4puoA-4jggA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		4 / 8 VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.06A 4q0bA-4jggA:
undetectable		 4q0bA-4jggA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.24A 4q0bC-4jggA:
1.2		 4q0bC-4jggA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.27A 5hbmA-4jggA:
undetectable		 5hbmA-4jggA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  86
LEU A 138
VAL A 130
GLY A 128
ALA A 129
 None
 1.04A 5ikqA-4jggA:
undetectable		 5ikqA-4jggA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  86
LEU A 138
VAL A 130
GLY A 128
ALA A 129
 None
 1.04A 5ikqB-4jggA:
undetectable		 5ikqB-4jggA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.27A 6bsgA-4jggA:
undetectable		 6bsgA-4jggA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.28A 6bsiA-4jggA:
undetectable		 6bsiA-4jggA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4jgg ESTERASE TESA
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.21A 6bsjA-4jggA:
undetectable		 6bsjA-4jggA:
18.85