SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4jgh CULLIN-5
(Homo
sapiens) 		4 / 8 GLN D 175
ARG D 181
LEU D 155
SER D 183
 None
 1.06A 1hk3A-4jghD:
2.8		 1hk3A-4jghD:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4jgh CULLIN-5
(Homo
sapiens) 		5 / 11 LEU D 176
PHE D 202
ILE D 178
GLY D 179
SER D 183
 None
 1.24A 3bpxA-4jghD:
2.6
3bpxB-4jghD:
undetectable		 3bpxA-4jghD:
18.04
3bpxB-4jghD:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 4jgh CULLIN-5
(Homo
sapiens) 		5 / 12 MET D 310
GLY D 283
MET D 300
MET D 231
LEU D 295
 None
 1.24A 3h52D-4jghD:
undetectable		 3h52D-4jghD:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4jgh CULLIN-5
(Homo
sapiens) 		4 / 8 LEU D 299
TYR D 230
TYR D 233
LEU D 238
 None
 1.07A 3v81A-4jghD:
undetectable		 3v81A-4jghD:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4jgh CULLIN-5
(Homo
sapiens) 		4 / 6 ASN D 267
ALA D 268
TYR D 214
ASP D 208
 None
 1.19A 4mdaA-4jghD:
undetectable		 4mdaA-4jghD:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4jgh CULLIN-5
(Homo
sapiens) 		3 / 3 ARG D 244
LYS D 237
GLU D 240
 None
 0.77A 5d0yA-4jghD:
undetectable		 5d0yA-4jghD:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4jgh CULLIN-5
(Homo
sapiens) 		5 / 11 GLN D  63
VAL D 135
ASP D 141
THR D 142
LEU D 114
 None
 1.36A 5jh7B-4jghD:
undetectable		 5jh7B-4jghD:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4jgh CULLIN-5
(Homo
sapiens) 		4 / 7 LEU D  43
ASP D  46
ALA D  49
TRP D  53
 None
 1.04A 5nwvA-4jghD:
undetectable		 5nwvA-4jghD:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4jgh CULLIN-5
(Homo
sapiens) 		4 / 6 PRO D 309
LEU D 293
PHE D 297
LEU D 299
 None
 1.22A 5tl8A-4jghD:
undetectable		 5tl8A-4jghD:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4jgh CULLIN-5
(Homo
sapiens) 		4 / 5 LEU D  65
VAL D 135
GLU D 115
LEU D 114
 None
 1.04A 5xooB-4jghD:
undetectable		 5xooB-4jghD:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4jgh CULLIN-5
(Homo
sapiens) 		4 / 8 ASP D  20
ARG D  23
ASP D  68
GLU D  67
 None
 1.05A 6mn4A-4jghD:
undetectable		 6mn4A-4jghD:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4jgh CULLIN-5
(Homo
sapiens) 		4 / 8 ASP D  20
ARG D  23
ASP D  68
GLU D  67
 None
 1.14A 6mn4B-4jghD:
undetectable		 6mn4B-4jghD:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4jgh CULLIN-5
(Homo
sapiens) 		4 / 6 ASP D  20
ARG D  23
ASP D  68
GLU D  67
 None
 1.35A 6mn5D-4jghD:
undetectable		 6mn5D-4jghD:
12.37