SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jgi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
4 / 8 HIS A 102
GLY A 179
LEU A 150
ASP A 100
COB  A 301 (-3.7A)
COB  A 301 (-3.2A)
COB  A 301 (-4.3A)
COB  A 301 (-3.5A)
0.71A 1aegA-4jgiA:
undetectable
1aegA-4jgiA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
4 / 5 ALA A  73
PHE A  42
ASN A  20
ASP A  24
None
1.00A 1yc2D-4jgiA:
5.2
1yc2D-4jgiA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
3 / 3 LEU A 173
ASN A 171
ARG A 170
None
0.72A 2qhfA-4jgiA:
undetectable
2qhfA-4jgiA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
5 / 12 ASP A 193
ILE A 143
VAL A 144
GLY A 145
ALA A 199
None
None
None
COB  A 301 (-3.6A)
COB  A 301 (-3.4A)
0.97A 3ekwB-4jgiA:
undetectable
3ekwB-4jgiA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
4 / 6 GLN A  36
LEU A  38
GLU A  37
LEU A   4
None
0.93A 3h5gA-4jgiA:
undetectable
3h5gC-4jgiA:
undetectable
3h5gA-4jgiA:
9.76
3h5gC-4jgiA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
5 / 12 GLY A 168
ASN A 171
GLY A 191
ALA A 192
LEU A 173
None
0.96A 3hs6B-4jgiA:
undetectable
3hs6B-4jgiA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
4 / 5 VAL A 190
ARG A 158
MET A 157
GLU A 159
None
1.44A 4hojA-4jgiA:
undetectable
4hojA-4jgiA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
5 / 12 GLY A  67
ALA A 115
PHE A  42
VAL A  23
GLN A  71
None
1.31A 4ryaA-4jgiA:
undetectable
4ryaA-4jgiA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
5 / 9 PHE A 195
GLY A 178
SER A 147
ILE A 176
ALA A 192
None
COB  A 301 (-3.6A)
COB  A 301 (-2.7A)
COB  A 301 ( 4.2A)
None
1.30A 5entC-4jgiA:
undetectable
5entC-4jgiA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
3 / 3 GLU A  57
ARG A  52
TYR A  58
None
0.41A 5trqB-4jgiA:
undetectable
5trqB-4jgiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
5 / 12 LEU A 173
VAL A 136
PRO A 141
PHE A 109
GLY A 117
None
None
None
COB  A 301 (-3.6A)
None
1.21A 5xipC-4jgiA:
6.8
5xipC-4jgiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
5 / 12 LEU A 173
VAL A 136
PRO A 141
PHE A 109
GLY A 117
None
None
None
COB  A 301 (-3.6A)
None
1.17A 5xiqA-4jgiA:
7.1
5xiqA-4jgiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
5 / 12 LEU A 173
VAL A 136
PRO A 141
PHE A 109
GLY A 117
None
None
None
COB  A 301 (-3.6A)
None
1.25A 5xiqD-4jgiA:
7.1
5xiqD-4jgiA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
4 / 5 GLY A 202
ASP A 201
ARG A 208
GLN A  43
COB  A 301 ( 4.1A)
None
None
None
1.21A 5zrfB-4jgiA:
4.7
5zrfB-4jgiA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
5 / 12 PHE A 195
LEU A 146
GLY A 145
ILE A 205
ASP A 201
None
None
COB  A 301 (-3.6A)
None
None
1.24A 6bxnB-4jgiA:
5.6
6bxnB-4jgiA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacteri
um
hafniense)
5 / 12 ILE A 108
THR A  96
VAL A  97
VAL A 127
VAL A 182
COB  A 301 ( 4.1A)
None
None
None
None
1.21A 6bzoC-4jgiA:
undetectable
6bzoC-4jgiA:
11.89