SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jgt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Homo
sapiens) 		4 / 7 PHE A  82
LEU A  32
VAL A  97
THR A  95
 None
 1.06A 2zaxA-4jgtA:
undetectable		 2zaxA-4jgtA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Homo
sapiens) 		4 / 6 GLY A 249
VAL A 252
HIS A  74
THR A 253
 PYR  A 401 (-3.6A)
PYR  A 401 ( 4.4A)
None
PYR  A 401 ( 4.6A)
 1.04A 3tj7A-4jgtA:
undetectable
3tj7B-4jgtA:
undetectable		 3tj7A-4jgtA:
16.08
3tj7B-4jgtA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Homo
sapiens) 		5 / 6 GLY A 249
VAL A 252
HIS A  74
SER A 250
THR A 253
 PYR  A 401 (-3.6A)
PYR  A 401 ( 4.4A)
None
PYR  A 401 (-2.3A)
PYR  A 401 ( 4.6A)
 1.20A 3tj7C-4jgtA:
undetectable
3tj7D-4jgtA:
undetectable		 3tj7C-4jgtA:
16.08
3tj7D-4jgtA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Homo
sapiens) 		5 / 6 VAL A 252
HIS A  74
SER A 250
THR A 253
GLY A 249
 PYR  A 401 ( 4.4A)
None
PYR  A 401 (-2.3A)
PYR  A 401 ( 4.6A)
PYR  A 401 (-3.6A)
 1.19A 3tj7C-4jgtA:
undetectable
3tj7D-4jgtA:
undetectable		 3tj7C-4jgtA:
16.08
3tj7D-4jgtA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Homo
sapiens) 		5 / 12 PRO A 149
LEU A  89
VAL A 113
VAL A  97
TYR A  85
 None
 1.40A 4kfbA-4jgtA:
undetectable		 4kfbA-4jgtA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Homo
sapiens) 		3 / 3 THR A 186
PRO A 212
ASP A 215
 None
 0.86A 5l8dB-4jgtA:
undetectable		 5l8dB-4jgtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Homo
sapiens) 		3 / 3 THR A 186
PRO A 212
ASP A 215
 None
 0.86A 5mwuB-4jgtA:
undetectable		 5mwuB-4jgtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Homo
sapiens) 		5 / 12 ALA A 258
PRO A 267
GLY A 265
ALA A 254
ARG A 112
 None
 1.32A 5zvgA-4jgtA:
undetectable		 5zvgA-4jgtA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Homo
sapiens) 		5 / 12 ALA A 258
PRO A 267
GLY A 265
ALA A 254
ARG A 112
 None
 1.32A 5zvgB-4jgtA:
undetectable		 5zvgB-4jgtA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Homo
sapiens) 		3 / 3 ALA A 185
PHE A 213
GLN A 105
 None
 0.75A 6eceA-4jgtA:
2.5		 6eceA-4jgtA:
25.07