SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 6 HIS A 516
LEU A 437
LEU A 518
PRO A 521
 None
 1.31A 1hz4A-4jgvA:
undetectable		 1hz4A-4jgvA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 446
LEU A 449
ALA A 452
VAL A 498
ILE A 417
 None
None
None
GOL  A 606 ( 4.1A)
None
 1.15A 1s9pA-4jgvA:
20.4		 1s9pA-4jgvA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 446
LEU A 449
ALA A 452
VAL A 498
ILE A 417
 None
None
None
GOL  A 606 ( 4.1A)
None
 1.10A 1s9pD-4jgvA:
22.1		 1s9pD-4jgvA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A 570
GLN A 571
PHE A 574
PHE A 592
 None
GOL  A 605 ( 4.0A)
None
None
 0.80A 1v54C-4jgvA:
undetectable
1v54J-4jgvA:
undetectable		 1v54C-4jgvA:
21.99
1v54J-4jgvA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		3 / 3 LYS A 577
ASP A 436
ASP A 589
 None
 0.92A 2br4D-4jgvA:
undetectable		 2br4D-4jgvA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 8 ALA A 488
PHE A 489
ALA A 452
LEU A 449
 None
 0.77A 2bxmA-4jgvA:
undetectable		 2bxmA-4jgvA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A 570
GLN A 571
PHE A 574
PHE A 592
 None
GOL  A 605 ( 4.0A)
None
None
 0.80A 2dyrC-4jgvA:
undetectable
2dyrJ-4jgvA:
undetectable		 2dyrC-4jgvA:
21.99
2dyrJ-4jgvA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A 570
GLN A 571
PHE A 574
PHE A 592
 None
GOL  A 605 ( 4.0A)
None
None
 0.78A 2dyrP-4jgvA:
undetectable
2dyrW-4jgvA:
undetectable		 2dyrP-4jgvA:
21.99
2dyrW-4jgvA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A 570
GLN A 571
PHE A 574
PHE A 592
 None
GOL  A 605 ( 4.0A)
None
None
 0.82A 2eikP-4jgvA:
undetectable
2eikW-4jgvA:
undetectable		 2eikP-4jgvA:
21.99
2eikW-4jgvA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A 570
GLN A 571
PHE A 574
PHE A 592
 None
GOL  A 605 ( 4.0A)
None
None
 0.84A 2eilC-4jgvA:
undetectable
2eilJ-4jgvA:
undetectable		 2eilC-4jgvA:
21.99
2eilJ-4jgvA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 5 LEU A 410
GLY A 412
ILE A 587
ILE A 588
 None
 0.86A 2q9rA-4jgvA:
undetectable		 2q9rA-4jgvA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A 570
GLN A 571
PHE A 574
PHE A 592
 None
GOL  A 605 ( 4.0A)
None
None
 0.86A 3ag4C-4jgvA:
undetectable
3ag4J-4jgvA:
undetectable		 3ag4C-4jgvA:
21.99
3ag4J-4jgvA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 7 LEU A 570
GLN A 571
PHE A 574
PHE A 592
 None
GOL  A 605 ( 4.0A)
None
None
 0.83A 3ag4P-4jgvA:
undetectable
3ag4W-4jgvA:
undetectable		 3ag4P-4jgvA:
21.99
3ag4W-4jgvA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		5 / 12 PHE A 443
ALA A 442
THR A 595
ARG A 515
LEU A 562
 None
 1.08A 3aobC-4jgvA:
undetectable		 3aobC-4jgvA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 7 LEU A 570
GLN A 571
PHE A 574
PHE A 592
 None
GOL  A 605 ( 4.0A)
None
None
 0.84A 3asnC-4jgvA:
undetectable
3asnJ-4jgvA:
undetectable		 3asnC-4jgvA:
21.99
3asnJ-4jgvA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		5 / 11 GLY A 376
ILE A 463
THR A 379
LYS A 381
LEU A 382
 GOL  A 607 (-3.3A)
None
None
None
None
 1.41A 3bexC-4jgvA:
undetectable
3bexD-4jgvA:
undetectable		 3bexC-4jgvA:
22.55
3bexD-4jgvA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 6 PHE A 387
GLN A 474
LEU A 468
LEU A 470
 None
 0.99A 3bgdA-4jgvA:
undetectable		 3bgdA-4jgvA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 5 LEU A 562
LEU A 559
LEU A 506
SER A 507
 None
T94  A 601 ( 4.0A)
T94  A 601 ( 4.2A)
None
 0.76A 3vhuA-4jgvA:
20.4		 3vhuA-4jgvA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 6 LEU A 570
PHE A 592
LEU A 596
PHE A 598
 None
 1.08A 3wg7C-4jgvA:
undetectable
3wg7J-4jgvA:
undetectable		 3wg7C-4jgvA:
21.99
3wg7J-4jgvA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		3 / 3 PHE A 443
ASP A 436
ARG A 418
 None
 0.77A 4eahF-4jgvA:
undetectable		 4eahF-4jgvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		3 / 3 PHE A 443
ASP A 436
ARG A 418
 None
 0.77A 4eahG-4jgvA:
undetectable		 4eahG-4jgvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 5 CYH A 505
CYH A 534
LEU A 365
ASP A 499
 None
None
None
GOL  A 606 (-3.8A)
 1.20A 5mafA-4jgvA:
undetectable		 5mafA-4jgvA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1
(Homo
sapiens) 		4 / 7 LEU A 570
PHE A 592
LEU A 596
PHE A 598
 None
 1.00A 5x1fP-4jgvA:
undetectable
5x1fW-4jgvA:
undetectable		 5x1fP-4jgvA:
21.99
5x1fW-4jgvA:
13.93