SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jhp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		6 / 12 LEU C  91
ALA C 154
THR C  99
PHE C 130
LEU C  84
ALA C  92
 None
 1.23A 1ao8A-4jhpC:
undetectable		 1ao8A-4jhpC:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		4 / 8 HIS C  46
LEU C 100
THR C  99
HIS C  98
 None
 1.04A 1azmA-4jhpC:
undetectable		 1azmA-4jhpC:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		4 / 7 ASN C  97
GLY C 113
THR C 111
SER C 152
 None
 1.20A 2o5yH-4jhpC:
undetectable
2o5yL-4jhpC:
undetectable		 2o5yH-4jhpC:
21.74
2o5yL-4jhpC:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 10 MET C 316
ALA C 365
LEU C  40
MET C 361
VAL C 362
 None
 1.43A 2wuzA-4jhpC:
undetectable		 2wuzA-4jhpC:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 10 MET C 316
ALA C 365
LEU C  40
MET C 361
VAL C 362
 None
 1.41A 2wuzB-4jhpC:
undetectable		 2wuzB-4jhpC:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY C 198
GLY C 148
SER C 301
GLY C 252
GLY C 251
 None
 1.05A 3axzA-4jhpC:
undetectable		 3axzA-4jhpC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 ILE C 289
VAL C 288
ILE C 241
ALA C 249
ILE C 300
 None
 0.86A 3ekwB-4jhpC:
undetectable		 3ekwB-4jhpC:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 11 GLY C  43
GLY C 358
ALA C 355
ALA C  48
ARG C  96
 None
 0.99A 3g88A-4jhpC:
undetectable		 3g88A-4jhpC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 11 GLY C  43
GLY C 358
ALA C 355
ALA C  48
ARG C  96
 None
 0.98A 3g88B-4jhpC:
undetectable		 3g88B-4jhpC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY C  43
GLY C 358
ALA C 355
ALA C  48
ARG C  96
 None
 0.98A 3g89A-4jhpC:
undetectable		 3g89A-4jhpC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 11 GLY C  43
GLY C 358
ALA C 355
ALA C  48
ARG C  96
 None
 0.99A 3g89B-4jhpC:
undetectable		 3g89B-4jhpC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY C  43
GLY C 358
ALA C 355
ALA C  48
ARG C  96
 None
 1.00A 3g8bA-4jhpC:
undetectable		 3g8bA-4jhpC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY C  43
GLY C 358
ALA C 355
ALA C  48
ARG C  96
 None
 1.01A 3g8bB-4jhpC:
undetectable		 3g8bB-4jhpC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		4 / 7 LEU C 224
LEU C 222
THR C 255
VAL C 257
 None
 0.90A 3ozkB-4jhpC:
undetectable		 3ozkB-4jhpC:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 ILE C 300
ALA C 262
THR C 259
VAL C 256
VAL C 257
 None
 1.04A 3rukB-4jhpC:
undetectable		 3rukB-4jhpC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		4 / 4 LEU C 327
GLY C 325
GLY C 322
THR C 335
 None
 0.87A 3si7A-4jhpC:
undetectable		 3si7A-4jhpC:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 LEU C 211
VAL C 238
PHE C 266
VAL C 248
PHE C 214
 None
 1.32A 3u9fH-4jhpC:
undetectable
3u9fI-4jhpC:
undetectable		 3u9fH-4jhpC:
20.20
3u9fI-4jhpC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		4 / 4 ASN C 107
SER C 152
LEU C 100
THR C 137
 None
 1.47A 4an2A-4jhpC:
undetectable		 4an2A-4jhpC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		3 / 3 HIS C 368
GLY C 314
ILE C 350
 None
 0.64A 4k50I-4jhpC:
undetectable		 4k50I-4jhpC:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 LEU C 145
VAL C 108
THR C  99
HIS C  46
GLY C  65
 None
 1.32A 4q15A-4jhpC:
undetectable		 4q15A-4jhpC:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY C 198
GLY C 148
SER C 301
GLY C 252
GLY C 251
 None
 1.03A 4yvgA-4jhpC:
undetectable		 4yvgA-4jhpC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		4 / 7 CYH C 302
GLY C 320
ASN C 305
HIS C 254
 None
 1.31A 5a5zC-4jhpC:
undetectable		 5a5zC-4jhpC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		4 / 7 HIS C  98
GLY C 112
ASN C  97
HIS C  46
 None
 1.30A 5a5zC-4jhpC:
undetectable		 5a5zC-4jhpC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY C 269
GLY C 272
GLY C 277
LEU C 280
LEU C 268
 None
 1.12A 5c0oE-4jhpC:
undetectable		 5c0oE-4jhpC:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		4 / 5 ILE C 292
LEU C 280
HIS C 254
VAL C 256
 None
 1.10A 5jmnB-4jhpC:
undetectable		 5jmnB-4jhpC:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY C 112
GLY C  68
ILE C 133
VAL C 101
LEU C 100
 None
 1.03A 5wyqA-4jhpC:
undetectable		 5wyqA-4jhpC:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY C 198
GLY C 148
SER C 301
GLY C 252
GLY C 251
 None
 1.03A 5wyqA-4jhpC:
undetectable		 5wyqA-4jhpC:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens) 		4 / 8 GLY C 267
LEU C 222
GLY C 223
GLU C 216
 None
 0.63A 6mdqA-4jhpC:
undetectable		 6mdqA-4jhpC:
12.24