SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jhr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTI_C_CCSC47_0 (GLUTATHIONE S-TRANSFERASE)	4jhr	G-PROTEIN-SIGNALING MODULATOR 2 (Mus musculus)	4 / 6	THR A 204 LEU A 201 GLY A 199 TYR A 178	None	1.21A	1gtiC-4jhrA: undetectable	1gtiC-4jhrA: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C49_B_ADNB1301_1 (SUGAR KINASE MJ0406)	4jhr	G-PROTEIN-SIGNALING MODULATOR 2 (Mus musculus)	5 / 7	HIS A 205 ALA A 217 GLY A 199 GLY A 202 ASN A 203	None	1.37A	2c49B-4jhrA: undetectable	2c49B-4jhrA: 20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CDQ_B_SAMB1500_0 (ASPARTOKINASE)	4jhr	G-PROTEIN-SIGNALING MODULATOR 2 (Mus musculus)	4 / 7	ASP A 176 SER A 183 LEU A 138 GLU A 134	None	1.05A	2cdqB-4jhrA: undetectable	2cdqB-4jhrA: 20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YDO_A_ADNA400_1 (ADENOSINE RECEPTOR A2A)	4jhr	G-PROTEIN-SIGNALING MODULATOR 2 (Mus musculus)	5 / 12	LEU A 287 THR A 286 GLU A 622 SER A 320 HIS A 298	None	1.24A	2ydoA-4jhrA: undetectable	2ydoA-4jhrA: 23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QJ7_A_SPMA264_1 (THYMIDYLATE SYNTHASE)	4jhr	G-PROTEIN-SIGNALING MODULATOR 2 (Mus musculus)	4 / 8	ARG A 235 ALA A 275 GLN A 276 SER A 280	None	1.04A	3qj7A-4jhrA: undetectable 3qj7D-4jhrA: undetectable	3qj7A-4jhrA: 21.51 3qj7D-4jhrA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WDM_A_ADNA901_1 (4-PHOSPHOPANTOATE--B ETA-ALANINE LIGASE)	4jhr	G-PROTEIN-SIGNALING MODULATOR 2 (Mus musculus)	5 / 9	ALA A 193 ARG A 196 GLY A 195 LEU A 182 ASN A 200	None	1.15A	3wdmA-4jhrA: undetectable	3wdmA-4jhrA: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HXY_B_ACAB502_1 (PLM1)	4jhr	G-PROTEIN-SIGNALING MODULATOR 2 (Mus musculus)	4 / 7	VAL A 619 SER A 320 TYR A 279 ASP A 589	None	1.05A	4hxyB-4jhrA: undetectable	4hxyB-4jhrA: 23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KN2_B_LYAB304_1 (FOLATE RECEPTOR BETA)	4jhr	G-PROTEIN-SIGNALING MODULATOR 2 (Mus musculus)	5 / 12	THR A 261 TYR A 258 ARG A 316 GLY A 616 TYR A 297	None	1.15A	4kn2B-4jhrA: undetectable	4kn2B-4jhrA: 21.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GTI_C_CCSC47_0","GLUTATHIONE S-TRANSFERASE","4jhr","G-PROTEIN-SIGNALING MODULATOR 2","Mus musculus",4,"THR A 204;LEU A 201;GLY A 199;TYR A 178","None","1.21A","1gtiC-4jhrA:undetectable","1gtiC-4jhrA:21.04"],["2C49_B_ADNB1301_1","SUGAR KINASE MJ0406","4jhr","G-PROTEIN-SIGNALING MODULATOR 2","Mus musculus",5,"HIS A 205;ALA A 217;GLY A 199;GLY A 202;ASN A 203","None","1.37A","2c49B-4jhrA:undetectable","2c49B-4jhrA:20.79"],["2CDQ_B_SAMB1500_0","ASPARTOKINASE","4jhr","G-PROTEIN-SIGNALING MODULATOR 2","Mus musculus",4,"ASP A 176;SER A 183;LEU A 138;GLU A 134","None","1.05A","2cdqB-4jhrA:undetectable","2cdqB-4jhrA:20.61"],["2YDO_A_ADNA400_1","ADENOSINE RECEPTOR A2A","4jhr","G-PROTEIN-SIGNALING MODULATOR 2","Mus musculus",5,"LEU A 287;THR A 286;GLU A 622;SER A 320;HIS A 298","None","1.24A","2ydoA-4jhrA:undetectable","2ydoA-4jhrA:23.40"],["3QJ7_A_SPMA264_1","THYMIDYLATE SYNTHASE;THYMIDYLATE SYNTHASE","4jhr","G-PROTEIN-SIGNALING MODULATOR 2","Mus musculus",4,"ARG A 235;ALA A 275;GLN A 276;SER A 280","None","1.04A","3qj7A-4jhrA:undetectable;3qj7D-4jhrA:undetectable","3qj7A-4jhrA:21.51;3qj7D-4jhrA:21.51"],["3WDM_A_ADNA901_1","4-PHOSPHOPANTOATE--BETA-ALANINE LIGASE","4jhr","G-PROTEIN-SIGNALING MODULATOR 2","Mus musculus",5,"ALA A 193;ARG A 196;GLY A 195;LEU A 182;ASN A 200","None","1.15A","3wdmA-4jhrA:undetectable","3wdmA-4jhrA:22.38"],["4HXY_B_ACAB502_1","PLM1","4jhr","G-PROTEIN-SIGNALING MODULATOR 2","Mus musculus",4,"VAL A 619;SER A 320;TYR A 279;ASP A 589","None","1.05A","4hxyB-4jhrA:undetectable","4hxyB-4jhrA:23.16"],["4KN2_B_LYAB304_1","FOLATE RECEPTOR BETA","4jhr","G-PROTEIN-SIGNALING MODULATOR 2","Mus musculus",5,"THR A 261;TYR A 258;ARG A 316;GLY A 616;TYR A 297","None","1.15A","4kn2B-4jhrA:undetectable","4kn2B-4jhrA:21.21"]]