SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jhz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 7 ARG A 327
TYR A 472
ARG A 562
ASN A 566
 None
1KV  A 701 (-3.8A)
1KV  A 701 (-4.0A)
None
 1.12A 1f9gA-4jhzA:
undetectable		 1f9gA-4jhzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 8 VAL A 405
ASP A 342
ASP A 339
LEU A 395
 None
 1.06A 1pk2A-4jhzA:
undetectable		 1pk2A-4jhzA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 VAL A 543
ALA A 542
HIS A 497
 None
 0.66A 1q23C-4jhzA:
undetectable		 1q23C-4jhzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 VAL A 543
ALA A 542
HIS A 497
 None
 0.63A 1q23H-4jhzA:
undetectable		 1q23H-4jhzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 VAL A 543
ALA A 542
HIS A 497
 None
 0.68A 1q23G-4jhzA:
undetectable		 1q23G-4jhzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 VAL A 543
ALA A 542
HIS A 497
 None
 0.74A 1q23L-4jhzA:
undetectable		 1q23L-4jhzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 VAL A 543
ALA A 542
HIS A 497
 None
 0.59A 1q23J-4jhzA:
undetectable		 1q23J-4jhzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 12 GLY A 294
TYR A 333
ILE A 349
ARG A 327
HIS A 330
 None
 1.38A 1tmxB-4jhzA:
3.0		 1tmxB-4jhzA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 12 ARG A 327
GLU A 504
PHE A 164
ASN A 466
VAL A 446
 None
 1.36A 1x70A-4jhzA:
undetectable		 1x70A-4jhzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 12 THR A 352
TYR A 331
GLY A 109
GLY A  95
ILE A 143
 None
 0.83A 2fk8A-4jhzA:
undetectable		 2fk8A-4jhzA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 10 ILE A  12
VAL A 128
VAL A  73
ILE A 130
VAL A  99
 None
 1.07A 2nnjA-4jhzA:
undetectable		 2nnjA-4jhzA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_A_ETVA302_1
(DEOXYCYTIDINE KINASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 12 ILE A 456
GLN A 498
ARG A 433
ASP A 461
PHE A 460
 None
 1.44A 2no6A-4jhzA:
undetectable		 2no6A-4jhzA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 11 ILE A 456
GLN A 498
ARG A 433
ASP A 461
PHE A 460
 None
 1.42A 2no6B-4jhzA:
0.0		 2no6B-4jhzA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 11 ILE A 456
GLN A 498
ARG A 433
ASP A 461
PHE A 460
 None
 1.44A 2noaB-4jhzA:
undetectable		 2noaB-4jhzA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 7 GLY A 245
PHE A 288
ILE A 283
PHE A 290
 None
 0.95A 2qmzA-4jhzA:
undetectable
2qmzB-4jhzA:
undetectable		 2qmzA-4jhzA:
18.67
2qmzB-4jhzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 11 ASN A 412
GLU A 413
TYR A 468
GLU A 504
TRP A 549
 None
1KV  A 701 (-3.4A)
1KV  A 701 ( 4.5A)
None
None
 0.76A 2v3dB-4jhzA:
18.2		 2v3dB-4jhzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 7 TYR A 468
TYR A 533
GLU A 546
TYR A 505
 1KV  A 701 ( 4.5A)
None
None
None
 1.33A 2xytD-4jhzA:
undetectable		 2xytD-4jhzA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 7 TYR A 468
TYR A 533
GLU A 546
TYR A 505
 1KV  A 701 ( 4.5A)
None
None
None
 1.41A 2xytG-4jhzA:
undetectable		 2xytG-4jhzA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 11 THR A 291
GLY A 292
PHE A 293
GLY A 322
ILE A 321
 None
 1.25A 2y7kA-4jhzA:
undetectable		 2y7kA-4jhzA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 12 THR A 291
GLY A 292
PHE A 293
GLY A 322
ILE A 321
 None
 1.26A 2y7kC-4jhzA:
undetectable		 2y7kC-4jhzA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 10 THR A 291
GLY A 292
PHE A 293
GLY A 322
ILE A 321
 None
 1.27A 2y7wB-4jhzA:
undetectable		 2y7wB-4jhzA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 11 LEU A 584
ALA A 323
ASP A 319
ILE A 570
ILE A 321
 None
 0.97A 3ebzA-4jhzA:
undetectable		 3ebzA-4jhzA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 12 ASN A 412
VAL A 444
GLY A 294
ASN A 550
ARG A 575
 None
 0.94A 3k13B-4jhzA:
9.6		 3k13B-4jhzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 ASN A 445
ASN A 412
GLU A 504
 None
 0.85A 3kpdC-4jhzA:
undetectable		 3kpdC-4jhzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 9 LEU A 459
PHE A 460
SER A 457
ILE A 410
ALA A 411
 None
 1.26A 3mdtA-4jhzA:
undetectable		 3mdtA-4jhzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 11 LEU A 584
ALA A 323
ASP A 319
ILE A 570
ILE A 321
 None
 0.98A 3s53B-4jhzA:
undetectable		 3s53B-4jhzA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 HIS A 296
GLU A 504
ASN A 412
 None
 1.03A 4bupB-4jhzA:
undetectable		 4bupB-4jhzA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 12 GLY A 245
GLY A 247
ILE A 346
ALA A 341
ASP A 319
 None
 1.20A 4kicA-4jhzA:
undetectable		 4kicA-4jhzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 LEU A 241
ARG A 272
MET A 407
 None
 0.88A 4m11C-4jhzA:
undetectable		 4m11C-4jhzA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 8 THR A 188
VAL A 202
SER A 201
HIS A 192
 None
 0.54A 4qknA-4jhzA:
undetectable		 4qknA-4jhzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 6 GLY A 245
PHE A 288
ILE A 283
PHE A 290
 None
 1.06A 4qogA-4jhzA:
undetectable
4qogB-4jhzA:
undetectable		 4qogA-4jhzA:
18.90
4qogB-4jhzA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 ASP A 399
HIS A 402
LYS A 400
 None
 0.93A 4qzuD-4jhzA:
undetectable		 4qzuD-4jhzA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		5 / 12 SER A  50
SER A 329
LEU A 138
THR A  92
GLY A 110
 None
 1.32A 4zjlA-4jhzA:
undetectable		 4zjlA-4jhzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 VAL A  73
ARG A 172
PRO A  48
 None
 0.81A 5koxA-4jhzA:
undetectable		 5koxA-4jhzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 6 ARG A  87
ALA A  90
PRO A 113
GLU A 336
 None
 1.25A 5odqA-4jhzA:
undetectable		 5odqA-4jhzA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 8 TRP A 471
TYR A 472
TRP A 521
VAL A 563
 None
1KV  A 701 (-3.8A)
None
None
 0.98A 5vlmF-4jhzA:
undetectable		 5vlmF-4jhzA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 HIS A 296
GLU A 504
ASN A 412
 None
 0.98A 5wbvA-4jhzA:
undetectable		 5wbvA-4jhzA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 HIS A 296
GLU A 504
ASN A 412
 None
 0.99A 5wbvB-4jhzA:
undetectable		 5wbvB-4jhzA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 4 VAL A 462
LEU A 463
LEU A 496
ASP A 454
 None
 1.34A 5xv7A-4jhzA:
undetectable		 5xv7A-4jhzA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 ASP A  89
ARG A  87
ASP A 339
 None
 0.87A 5zvgA-4jhzA:
undetectable		 5zvgA-4jhzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 6 GLY A 247
VAL A 406
PHE A 288
PHE A 290
 None
 1.06A 6h7lA-4jhzA:
undetectable		 6h7lA-4jhzA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 6 GLY A 247
VAL A 406
PHE A 288
PHE A 290
 None
 1.05A 6h7lB-4jhzA:
undetectable		 6h7lB-4jhzA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		3 / 3 TRP A 408
ILE A 349
ASP A 350
 None
 0.64A 6i0y7-4jhzA:
undetectable		 6i0y7-4jhzA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jhz BETA-GLUCURONIDASE
(Escherichia
coli) 		4 / 7 HIS A 315
TYR A 333
HIS A 344
LEU A 395
 None
 1.08A 6nmfA-4jhzA:
undetectable
6nmfC-4jhzA:
undetectable
6nmfP-4jhzA:
undetectable		 6nmfA-4jhzA:
19.84
6nmfC-4jhzA:
17.38
6nmfP-4jhzA:
17.38