SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 4 ARG A  30
ALA A  27
ALA A 228
GLU A 229
 None
 1.09A 1e7bB-4jigA:
undetectable		 1e7bB-4jigA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 GLU A  46
ALA A  44
SER A  16
 None
None
ACT  A 301 ( 3.8A)
 0.68A 1errB-4jigA:
undetectable		 1errB-4jigA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 120
ALA A 121
GLY A  94
ILE A  95
VAL A 169
 None
None
None
GOL  A 303 (-4.8A)
None
 0.99A 1k6cB-4jigA:
undetectable		 1k6cB-4jigA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 140
GLY A 138
GLY A 137
GLY A 181
ASN A 188
 None
 0.95A 1n2xB-4jigA:
8.4		 1n2xB-4jigA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 247
ALA A 245
ARG A 191
ALA A 230
ASP A 248
 None
 1.24A 2ejtA-4jigA:
4.4		 2ejtA-4jigA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 GLY A 120
ALA A 121
GLY A  94
ILE A  95
VAL A 169
 None
None
None
GOL  A 303 (-4.8A)
None
 0.81A 2fxdA-4jigA:
undetectable		 2fxdA-4jigA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 120
ALA A 121
GLY A  94
ILE A  95
VAL A 169
 None
None
None
GOL  A 303 (-4.8A)
None
 0.86A 2nnkA-4jigA:
undetectable		 2nnkA-4jigA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 VAL A  79
THR A  23
VAL A  52
GLY A  57
ALA A  59
 None
 1.19A 2x2iA-4jigA:
2.4		 2x2iA-4jigA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 VAL A  10
LEU A  11
GLY A  35
ILE A  61
SER A  16
 None
None
None
None
ACT  A 301 ( 3.8A)
 1.24A 3bjwH-4jigA:
undetectable		 3bjwH-4jigA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 ARG A 191
ALA A 245
THR A 173
ILE A 174
 None
 0.87A 3bpxA-4jigA:
undetectable
3bpxB-4jigA:
undetectable		 3bpxA-4jigA:
19.39
3bpxB-4jigA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 120
ALA A 121
GLY A  94
ILE A  95
VAL A 169
 None
None
None
GOL  A 303 (-4.8A)
None
 0.93A 3el4A-4jigA:
undetectable		 3el4A-4jigA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 GLY A 120
ALA A 121
GLY A  94
ILE A  95
VAL A 169
 None
None
None
GOL  A 303 (-4.8A)
None
 0.86A 3nu9B-4jigA:
undetectable		 3nu9B-4jigA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 ILE A 143
ASN A 117
ALA A 121
LEU A 176
LEU A 172
 None
 1.19A 3o02A-4jigA:
undetectable
3o02B-4jigA:
undetectable		 3o02A-4jigA:
21.70
3o02B-4jigA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 9 GLY A 120
ALA A 121
GLY A  94
ILE A  95
VAL A 169
 None
None
None
GOL  A 303 (-4.8A)
None
 0.96A 3u7sB-4jigA:
undetectable		 3u7sB-4jigA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 120
ALA A 121
GLY A  94
ILE A  95
VAL A 169
 None
None
None
GOL  A 303 (-4.8A)
None
 0.75A 3ucbB-4jigA:
undetectable		 3ucbB-4jigA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A 123
GLY A 120
MET A  75
ASN A  37
 None
 1.16A 3uq6B-4jigA:
6.6		 3uq6B-4jigA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ALA A 121
GLY A 120
GLY A  14
ASN A  37
ASN A  91
 None
None
ACT  A 301 ( 4.8A)
None
None
 1.28A 4e47C-4jigA:
undetectable		 4e47C-4jigA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 9 VAL A  34
VAL A  10
VAL A  62
ILE A  36
GLY A  20
 None
 1.24A 4fwdA-4jigA:
2.4		 4fwdA-4jigA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ALA A 121
GLY A 120
GLY A  14
ASN A  37
ASN A  91
 None
None
ACT  A 301 ( 4.8A)
None
None
 1.30A 4jdsC-4jigA:
undetectable		 4jdsC-4jigA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 9 ALA A  45
VAL A  66
GLY A  14
ALA A  15
ILE A  61
 None
None
ACT  A 301 ( 4.8A)
None
None
 0.99A 4r21B-4jigA:
undetectable		 4r21B-4jigA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4jig DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ALA A 121
GLY A 120
GLY A  14
ASN A  37
ASN A  91
 None
None
ACT  A 301 ( 4.8A)
None
None
 1.26A 5ayfA-4jigA:
undetectable		 5ayfA-4jigA:
21.55