SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 ILE A  34
PRO A  31
PHE A  24
ILE A   6
 None
 1.16A 2hjhA-4jisA:
undetectable		 2hjhA-4jisA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 11 THR A 137
ILE A 121
GLY A 211
PHE A 214
HIS A 110
 None
 1.25A 2y7kA-4jisA:
undetectable		 2y7kA-4jisA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 ILE A  32
LEU A 231
ALA A 229
ILE A 230
PHE A 116
 None
 1.13A 3b2rA-4jisA:
undetectable		 3b2rA-4jisA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 11 ILE A  32
LEU A 231
ALA A 229
ILE A 230
PHE A 116
 None
 1.12A 3b2rB-4jisA:
undetectable		 3b2rB-4jisA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 ASP A 136
VAL A 138
GLY A 166
ASP A 194
 None
 1.21A 3w9tA-4jisA:
undetectable		 3w9tA-4jisA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 ASP A 136
VAL A 138
GLY A 166
ASP A 194
 None
 1.20A 3w9tB-4jisA:
undetectable		 3w9tB-4jisA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 ASP A 136
VAL A 138
GLY A 166
ASP A 194
 None
 1.21A 3w9tC-4jisA:
undetectable		 3w9tC-4jisA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 ASP A 136
VAL A 138
GLY A 166
ASP A 194
 None
 1.21A 3w9tD-4jisA:
undetectable		 3w9tD-4jisA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 ASP A 136
VAL A 138
GLY A 166
ASP A 194
 None
 1.21A 3w9tE-4jisA:
undetectable		 3w9tE-4jisA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 ASP A 136
VAL A 138
GLY A 166
ASP A 194
 None
 1.20A 3w9tF-4jisA:
undetectable		 3w9tF-4jisA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 ASP A 136
VAL A 138
GLY A 166
ASP A 194
 None
 1.20A 3w9tG-4jisA:
undetectable		 3w9tG-4jisA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 THR A 168
PRO A 169
PHE A 172
ASN A 125
 None
 1.26A 4mf6A-4jisA:
undetectable		 4mf6A-4jisA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 7 ILE A 108
PHE A  46
THR A 118
LEU A 117
 None
 0.78A 5b1bN-4jisA:
undetectable
5b1bW-4jisA:
undetectable		 5b1bN-4jisA:
18.13
5b1bW-4jisA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 7 ILE A 108
PHE A  46
THR A 118
LEU A 117
 None
 0.80A 5b3sN-4jisA:
undetectable
5b3sW-4jisA:
undetectable		 5b3sN-4jisA:
18.13
5b3sW-4jisA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 7 ILE A 108
PHE A  46
THR A 118
LEU A 117
 None
 0.78A 5iy5N-4jisA:
undetectable
5iy5W-4jisA:
undetectable		 5iy5N-4jisA:
18.13
5iy5W-4jisA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SVL_A_ACTA411_0
(P2X PURINOCEPTOR 3)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 GLN A 170
VAL A 209
ASP A 136
ASN A 125
 None
 1.44A 5svlA-4jisA:
undetectable		 5svlA-4jisA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 ASP A  44
ASN A  43
ASP A 123
 None
 0.80A 5vopA-4jisA:
undetectable		 5vopA-4jisA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Bacillus
subtilis) 		3 / 3 ASP A  44
ASN A  43
ASP A 123
 None
 0.88A 5vopB-4jisA:
2.1		 5vopB-4jisA:
23.01