SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 7 ARG A  42
ILE A  43
ASP A  60
LEU A  59
 None
 0.79A 1rtsB-4jjaA:
undetectable		 1rtsB-4jjaA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		3 / 3 ASP A 129
ASP A 159
ASN A 164
 None
 0.73A 2bm9D-4jjaA:
3.0		 2bm9D-4jjaA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		3 / 3 LYS A 366
ASP A 129
ASP A 169
 None
 0.90A 2br4D-4jjaA:
3.0		 2br4D-4jjaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 6 VAL A  24
THR A 193
ASP A 159
PRO A 161
 None
 1.26A 2hdnJ-4jjaA:
undetectable
2hdnK-4jjaA:
undetectable
2hdnL-4jjaA:
undetectable		 2hdnJ-4jjaA:
20.85
2hdnK-4jjaA:
8.58
2hdnL-4jjaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 7 ALA A  44
ILE A  72
ILE A 124
HIS A  57
 None
 1.13A 2zm7A-4jjaA:
undetectable		 2zm7A-4jjaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		5 / 12 ILE A 139
ASN A 202
VAL A 217
LEU A 385
ILE A 157
 None
None
GOL  A 400 (-4.0A)
GOL  A 400 (-4.7A)
None
 1.09A 3em0B-4jjaA:
undetectable		 3em0B-4jjaA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 5 ASP A 126
LEU A 158
ILE A  43
PHE A  67
 None
 1.17A 3s3vA-4jjaA:
undetectable		 3s3vA-4jjaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		5 / 12 ILE A 218
LEU A 158
LEU A  58
LEU A  62
ILE A  45
 None
 1.02A 3uvvA-4jjaA:
undetectable		 3uvvA-4jjaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 8 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.21A 4feuF-4jjaA:
undetectable		 4feuF-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 7 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.18A 4fevD-4jjaA:
undetectable		 4fevD-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 7 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.18A 4fevF-4jjaA:
undetectable		 4fevF-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 8 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.16A 4fewD-4jjaA:
undetectable		 4fewD-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 8 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.17A 4fewF-4jjaA:
undetectable		 4fewF-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 7 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.21A 4fexB-4jjaA:
undetectable		 4fexB-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A 173
GLY A 170
PRO A 171
ILE A 186
LEU A 132
 None
 0.91A 4gc9A-4jjaA:
2.7		 4gc9A-4jjaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 8 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.19A 4gkhB-4jjaA:
undetectable		 4gkhB-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 8 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.17A 4gkhF-4jjaA:
undetectable		 4gkhF-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 7 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.19A 4gkhG-4jjaA:
undetectable		 4gkhG-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 8 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.17A 4gkiA-4jjaA:
undetectable		 4gkiA-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 8 ASP A 363
ASP A 323
ASP A 169
ASN A 321
 None
 1.19A 4gkiC-4jjaA:
undetectable		 4gkiC-4jjaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A  63
ASP A  60
VAL A  69
ALA A  28
LEU A 102
 None
 1.31A 4iarA-4jjaA:
undetectable		 4iarA-4jjaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		3 / 3 CYH A 302
ASN A 276
LYS A 300
 None
 0.75A 4k50A-4jjaA:
undetectable		 4k50A-4jjaA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		3 / 3 ASP A 169
TYR A 167
TRP A 369
 None
 1.30A 4p7nA-4jjaA:
undetectable		 4p7nA-4jjaA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 7 TYR A 223
ILE A 157
HIS A 225
LEU A 384
 None
 1.07A 4xo7B-4jjaA:
undetectable		 4xo7B-4jjaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 6 PHE A  79
LYS A  96
VAL A  69
ASP A  60
 None
 1.29A 5hesA-4jjaA:
undetectable		 5hesA-4jjaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 4 LYS A 381
HIS A 190
VAL A 189
ASN A 389
 None
 1.11A 5l2iA-4jjaA:
0.0		 5l2iA-4jjaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 5 LEU A 207
VAL A 201
MET A 141
CYH A 148
 None
 1.39A 5te0A-4jjaA:
undetectable		 5te0A-4jjaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		5 / 10 TYR A 246
ALA A 244
LEU A 231
VAL A 130
GLY A 131
 None
 1.37A 5zbdA-4jjaA:
undetectable		 5zbdA-4jjaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		5 / 12 ASP A 129
ALA A 198
LEU A 207
ARG A 143
LEU A 184
 None
None
None
None
GOL  A 403 ( 4.9A)
 1.14A 6ew0F-4jjaA:
3.2		 6ew0F-4jjaA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4jja HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		5 / 12 ASP A 129
ALA A 198
LEU A 207
ARG A 143
LEU A 184
 None
None
None
None
GOL  A 403 ( 4.9A)
 1.14A 6ew0G-4jjaA:
3.0		 6ew0G-4jjaA:
13.42