SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jjn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4jjn HISTONE H2A.2
HISTONE H2B.2
REGULATORY PROTEIN
SIR3
(Saccharomyces
cerevisiae) 		4 / 5 ARG K  30
THR D  51
LEU D  48
ALA C  61
 None
 1.43A 2e1qD-4jjnK:
undetectable		 2e1qD-4jjnK:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae) 		5 / 12 LEU C  94
LEU C  98
ALA C  67
VAL D  69
PHE C  26
 None
 1.29A 3b0wA-4jjnC:
undetectable		 3b0wA-4jjnC:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae) 		4 / 5 VAL D 114
THR C  53
THR D  99
ARG D 102
 None
 1.20A 3bjwA-4jjnD:
undetectable		 3bjwA-4jjnD:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae) 		5 / 12 ALA C  70
ILE C  80
SER D  61
ILE D  64
ILE C  63
 None
 1.20A 3clbB-4jjnC:
undetectable		 3clbB-4jjnC:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4jjn REGULATORY PROTEIN
SIR3
(Saccharomyces
cerevisiae) 		5 / 12 GLN K  12
LEU K  41
ASN K  81
LEU K  76
LEU K   8
 None
 1.28A 3fsuA-4jjnK:
undetectable		 3fsuA-4jjnK:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4jjn REGULATORY PROTEIN
SIR3
(Saccharomyces
cerevisiae) 		4 / 8 LEU K  41
TRP K  11
ASP K   7
ASP K   9
 None
 1.20A 3n2oC-4jjnK:
undetectable
3n2oD-4jjnK:
undetectable		 3n2oC-4jjnK:
21.74
3n2oD-4jjnK:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 VAL D  47
PHE C  26
VAL D  69
ILE D  57
 None
 0.87A 3zjqA-4jjnD:
undetectable		 3zjqA-4jjnD:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 VAL D  47
PHE C  26
VAL D  69
ILE D  57
 None
 0.88A 3zjqB-4jjnD:
undetectable		 3zjqB-4jjnD:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 SER C  19
GLU D 116
GLU C  65
 None
 0.72A 4ymgB-4jjnC:
undetectable		 4ymgB-4jjnC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4jjn REGULATORY PROTEIN
SIR3
(Saccharomyces
cerevisiae) 		4 / 7 ILE K  71
PHE K  50
VAL K  87
ILE K 141
 None
 0.73A 4zzbC-4jjnK:
undetectable
4zzbD-4jjnK:
undetectable		 4zzbC-4jjnK:
21.63
4zzbD-4jjnK:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae) 		5 / 10 LEU D  83
ALA D  80
GLU D  79
GLY C  38
LEU C  35
 None
 1.29A 5dx3A-4jjnD:
undetectable		 5dx3A-4jjnD:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae) 		5 / 11 LEU D  83
ALA D  80
GLU D  79
GLY C  38
LEU C  35
 None
 1.21A 5dxgB-4jjnD:
undetectable		 5dxgB-4jjnD:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae) 		5 / 12 LEU D  83
ALA D  80
GLU D  79
GLY C  38
LEU C  35
 None
 1.07A 5gtrA-4jjnD:
undetectable		 5gtrA-4jjnD:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae) 		4 / 6 SER D  81
GLY C  38
ASN C  39
ILE C  44
 None
 1.13A 5j4nA-4jjnD:
undetectable		 5j4nA-4jjnD:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 LEU D 105
ARG D  75
PHE D  68
LEU C  94
 None
 1.47A 5m10A-4jjnD:
undetectable		 5m10A-4jjnD:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4jjn HISTONE H2A.2
HISTONE H2B.2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 SER D  58
SER D  61
ALA C  70
 None
 0.69A 6dwnC-4jjnD:
undetectable		 6dwnC-4jjnD:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4jjn REGULATORY PROTEIN
SIR3
(Saccharomyces
cerevisiae) 		5 / 9 ILE K 192
ILE K 189
GLU K 206
VAL K 211
ILE K 187
 None
 1.25A 6hloA-4jjnK:
undetectable		 6hloA-4jjnK:
22.18