SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jkg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 12 ILE B1777
PHE B1893
PHE B1779
ILE B1937
LEU B1889
 None
 1.19A 1dhfB-4jkgB:
undetectable		 1dhfB-4jkgB:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		3 / 3 GLN B1835
TYR B1786
ARG B1787
 None
 0.82A 1gtbA-4jkgB:
undetectable		 1gtbA-4jkgB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 12 LEU B1889
ILE B1777
SER B1929
PHE B1933
ILE B1937
 None
 1.31A 1xotA-4jkgB:
undetectable		 1xotA-4jkgB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		4 / 7 LYS B1838
ASP B1782
ASP B1781
ARG B1832
 None
None
MG  B2001 (-2.5A)
None
 1.31A 2pk4A-4jkgB:
undetectable		 2pk4A-4jkgB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		4 / 6 ILE B1807
PRO B1858
LEU B1876
ILE B1861
 None
 0.87A 2q83B-4jkgB:
undetectable		 2q83B-4jkgB:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 9 MET B1868
ALA B1842
VAL B1780
ILE B1882
THR B1841
 None
 1.36A 3fl9H-4jkgB:
undetectable		 3fl9H-4jkgB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		4 / 6 LEU B1817
ILE B1807
ALA B1806
THR B1783
 None
 0.84A 3mdrA-4jkgB:
undetectable		 3mdrA-4jkgB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 12 ILE B1953
LEU B1988
LEU B1983
ILE B1987
ALA B1942
 None
 1.06A 3vrmA-4jkgB:
undetectable		 3vrmA-4jkgB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		6 / 12 VAL B1785
LEU B1919
LEU B1936
ALA B1806
LEU B1817
LEU B1905
 None
 1.50A 6ew0B-4jkgB:
undetectable		 6ew0B-4jkgB:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		6 / 12 VAL B1785
LEU B1919
LEU B1936
ALA B1806
LEU B1817
LEU B1905
 None
 1.49A 6ew0D-4jkgB:
undetectable		 6ew0D-4jkgB:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		6 / 12 VAL B1785
LEU B1919
LEU B1936
ALA B1806
LEU B1817
LEU B1905
 None
 1.49A 6ew0H-4jkgB:
undetectable		 6ew0H-4jkgB:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		6 / 12 VAL B1785
LEU B1919
LEU B1936
ALA B1806
LEU B1817
LEU B1905
 None
 1.49A 6ew0I-4jkgB:
undetectable		 6ew0I-4jkgB:
16.28