SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jkl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 7 ARG A 326
TYR A 468
ARG A 559
ASN A 563
 None
 1.19A 1f9gA-4jklA:
undetectable		 1f9gA-4jklA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 6 PRO A  28
ASP A  59
ASN A 128
TYR A  91
 None
 1.36A 1hpkA-4jklA:
undetectable		 1hpkA-4jklA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		5 / 12 GLY A 293
TYR A 332
ILE A 348
ARG A 326
HIS A 329
 None
 1.33A 1tmxB-4jklA:
undetectable		 1tmxB-4jklA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 6 THR A  85
PHE A 104
PHE A 159
ASN A 163
 None
 1.23A 1tt0A-4jklA:
0.7		 1tt0A-4jklA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 6 THR A  85
PHE A 104
PHE A 159
ASN A 163
 None
 1.26A 1tt0B-4jklA:
undetectable		 1tt0B-4jklA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 6 THR A  85
PHE A 104
PHE A 159
ASN A 163
 None
 1.21A 1tt0C-4jklA:
1.0		 1tt0C-4jklA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 6 THR A  85
PHE A 104
PHE A 159
ASN A 163
 None
 1.24A 1tt0D-4jklA:
1.2		 1tt0D-4jklA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 ASP A  46
GLU A 157
TYR A 330
 None
 0.74A 1wsvA-4jklA:
undetectable		 1wsvA-4jklA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZWP_A_NIMA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 5 LEU A 567
GLY A 503
TRP A 546
ASP A 505
 None
 1.40A 1zwpA-4jklA:
0.0		 1zwpA-4jklA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 7 GLY A 166
PHE A  44
ASP A  46
TYR A 164
 None
 1.18A 2aouB-4jklA:
undetectable		 2aouB-4jklA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 8 THR A 438
VAL A 456
VAL A 452
ARG A 463
 None
 0.87A 2ij7C-4jklA:
undetectable		 2ij7C-4jklA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 6 LEU A 173
LEU A  79
ILE A 175
ARG A 176
 None
 1.03A 2rlfA-4jklA:
undetectable
2rlfB-4jklA:
undetectable		 2rlfA-4jklA:
4.75
2rlfB-4jklA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		5 / 11 ASN A 407
GLU A 408
TYR A 464
GLU A 501
TRP A 546
 None
 0.80A 2v3dB-4jklA:
17.6		 2v3dB-4jklA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 8 TYR A 502
TYR A 465
LEU A 485
LEU A 540
 None
 0.87A 2w98B-4jklA:
undetectable		 2w98B-4jklA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 5 GLN A 358
THR A 373
HIS A 383
LEU A 136
 None
 1.38A 2zj0A-4jklA:
undetectable		 2zj0A-4jklA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 6 VAL A 252
VAL A 263
PHE A 182
ARG A 251
 None
 1.21A 3bjwF-4jklA:
undetectable		 3bjwF-4jklA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 5 GLN A 358
THR A 373
HIS A 383
LEU A 136
 None
 1.35A 3ce6C-4jklA:
undetectable		 3ce6C-4jklA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 SER A 196
ASP A 193
ASP A 198
 None
 0.90A 3iv6A-4jklA:
2.4		 3iv6A-4jklA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		5 / 12 ASN A 407
VAL A 440
GLY A 293
ASN A 547
ARG A 572
 None
 0.85A 3k13B-4jklA:
10.5		 3k13B-4jklA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 ARG A 449
GLU A 487
TYR A 465
 None
 0.75A 3k37B-4jklA:
undetectable		 3k37B-4jklA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 ARG A  54
VAL A  39
THR A  42
 None
 0.70A 3k4vD-4jklA:
undetectable		 3k4vD-4jklA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 5 ASN A 306
ALA A 308
ALA A 309
ARG A 572
 MG  A 602 ( 4.1A)
None
None
None
 1.38A 3kp2B-4jklA:
undetectable		 3kp2B-4jklA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 ASN A 441
ASN A 407
GLU A 501
 None
 0.86A 3kpdC-4jklA:
undetectable		 3kpdC-4jklA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 ASN A 441
ASN A 407
GLU A 501
 None
 0.94A 3kpdB-4jklA:
undetectable		 3kpdB-4jklA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 5 ILE A 481
ALA A 477
HIS A 531
MET A 529
 MG  A 603 ( 4.2A)
None
None
None
 1.12A 4ac9B-4jklA:
3.0
4ac9C-4jklA:
3.5		 4ac9B-4jklA:
21.60
4ac9C-4jklA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 5 ILE A 481
ALA A 477
HIS A 531
MET A 529
 MG  A 603 ( 4.2A)
None
None
None
 1.12A 4acaB-4jklA:
2.0
4acaC-4jklA:
3.4		 4acaB-4jklA:
21.60
4acaC-4jklA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 HIS A 295
GLU A 501
ASN A 407
 None
 1.03A 4bupB-4jklA:
undetectable		 4bupB-4jklA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 GLU A 296
THR A  85
HIS A 168
 None
 0.86A 4q15A-4jklA:
undetectable		 4q15A-4jklA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		5 / 9 ILE A 442
GLU A 408
ASN A 407
LEU A 136
PHE A 357
 None
 1.28A 4r38C-4jklA:
undetectable		 4r38C-4jklA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		5 / 10 ILE A 442
GLU A 408
ASN A 407
LEU A 136
PHE A 357
 None
 1.29A 4r3aB-4jklA:
undetectable		 4r3aB-4jklA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 4 PHE A  81
VAL A 167
ALA A  88
PHE A  60
 None
 1.05A 4w5rA-4jklA:
undetectable		 4w5rA-4jklA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 4 PHE A  81
VAL A 167
ALA A  88
PHE A  60
 None
 1.02A 4w5tA-4jklA:
2.0		 4w5tA-4jklA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		6 / 12 VAL A 401
SER A 324
LEU A 346
VAL A 458
ILE A 498
GLY A 542
 None
 1.40A 4y8wC-4jklA:
undetectable		 4y8wC-4jklA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 5 PHE A  81
VAL A 167
ALA A  88
PHE A  60
 None
 1.05A 4z4dA-4jklA:
2.0		 4z4dA-4jklA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 5 PHE A  81
VAL A 167
ALA A  88
PHE A  60
 None
 1.06A 4z4eA-4jklA:
2.0		 4z4eA-4jklA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		5 / 12 SER A  43
SER A 328
LEU A 131
THR A  85
GLY A 103
 None
 1.33A 4zjlA-4jklA:
undetectable		 4zjlA-4jklA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		5 / 12 GLU A 219
GLY A 344
ASN A 244
VAL A 401
ASN A 283
 None
 1.39A 5kbwB-4jklA:
undetectable		 5kbwB-4jklA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 THR A 105
PRO A 331
ASP A 349
 None
 0.94A 5l8dB-4jklA:
undetectable		 5l8dB-4jklA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 THR A 105
PRO A 331
ASP A 349
 None
 0.94A 5mwuB-4jklA:
undetectable		 5mwuB-4jklA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 HIS A 295
GLU A 501
ASN A 407
 None
 0.98A 5wbvA-4jklA:
undetectable		 5wbvA-4jklA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 HIS A 295
GLU A 501
ASN A 407
 None
 0.99A 5wbvB-4jklA:
undetectable		 5wbvB-4jklA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		3 / 3 TRP A 403
ILE A 348
ASP A 349
 None
 0.61A 6i0y7-4jklA:
undetectable		 6i0y7-4jklA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4jkl BETA-GLUCURONIDASE
(Streptococcus
agalactiae) 		4 / 7 HIS A 329
ARG A 559
HIS A 564
ASP A 160
 None
 1.39A 6mn4F-4jklA:
undetectable		 6mn4F-4jklA:
16.50